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Dysregulation of se...
Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetes
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- Lamichhane, Santosh (författare)
- Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
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- Sen, Partho, 1983- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
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- Dickens, Alex M. (författare)
- Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; Department of Chemistry, University of Turku, Turku, Finland
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- Alves, Marina Amaral (författare)
- Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; Walter Mors Institute of Research on Natural Products, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
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- Härkönen, Taina (författare)
- Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland
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- Honkanen, Jarno (författare)
- Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland
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- Vatanen, Tommi (författare)
- The Liggins Institute, University of Auckland, Auckland, New Zealand; The Broad Institute of MIT and Harvard, Cambridge, MA, USA
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- Xavier, Ramnik J. (författare)
- The Broad Institute of MIT and Harvard, Cambridge, MA, USA
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- Hyötyläinen, Tuulia, 1971- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Knip, Mikael (författare)
- Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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- Oresic, Matej, 1967- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
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(creator_code:org_t)
- Cell Press, 2022
- 2022
- Engelska.
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Ingår i: Cell Reports Medicine. - : Cell Press. - 2666-3791. ; 3:10
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The gut microbiota is crucial in the regulation of bile acid (BA) metabolism. However, not much is known about the regulation of BAs during progression to type 1 diabetes (T1D). Here, we analyzed serum and stool BAs in longitudinal samples collected at 3, 6, 12, 18, 24, and 36 months of age from children who developed a single islet autoantibody (AAb) (P1Ab; n = 23) or multiple islet AAbs (P2Ab; n = 13) and controls (CTRs; n = 38) who remained AAb negative. We also analyzed the stool microbiome in a subgroup of these children. Factor analysis showed that age had the strongest impact on both BA and microbiome profiles. We found that at an early age, systemic BAs and microbial secondary BA pathways were altered in the P2Ab group compared with the P1Ab and CTR groups. Our findings thus suggest that dysregulated BA metabolism in early life may contribute to the risk and pathogenesis of T1D.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Bile acid
- genome-scale metabolic modeling
- gut microbiome
- islet autoimmunity
- lipid metabolism
- lipidomics
- metabolomics
- microbial metabolism
- type 1 diabetes
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- art (ämneskategori)
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Lamichhane, Sant ...
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Sen, Partho, 198 ...
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Dickens, Alex M.
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Alves, Marina Am ...
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Härkönen, Taina
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Honkanen, Jarno
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visa fler...
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Vatanen, Tommi
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Xavier, Ramnik J ...
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Hyötyläinen, Tuu ...
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Knip, Mikael
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Oresic, Matej, 1 ...
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visa färre...
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Örebro universitet