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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004914naa a2200457 4500
001oai:lup.lub.lu.se:8625e4b3-5b86-42c9-a8ed-1d2f56000208
003SwePub
008200330s2020 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/8625e4b3-5b86-42c9-a8ed-1d2f560002082 URI
0247 a https://doi.org/10.1016/j.mrgentox.2020.5031672 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Corredor, Zurayu Autonomous University of Barcelona4 aut
2451 0a Loci associated with genomic damage levels in chronic kidney disease patients and controls
264 1b Elsevier BV,c 2020
520 a Chronic kidney disease (CKD) is a multifactorial disorder with an important genetic component, and several studies have demonstrated potential associations with allelic variants. In addition, CKD patients are also characterized by high levels of genomic damage. Nevertheless, no studies have established relationships between DNA damage, or genomic instability present in CKD patients, and gene polymorphisms. To fill in this gap, the potential role of polymorphisms in genes involved in base excision repair (OGG1, rs1052133; MUTYH, rs3219489; XRCC1, rs25487), nucleotide excision repair (ERCC2/XPD, rs1799793, rs171140, rs13181; ERCC4, rs3136166); phase II metabolism (GSTP1, rs749174; GSTO1, rs2164624; GSTO2, rs156697), and antioxidant enzymes (SOD1, rs17880135, rs1041740, rs202446; SOD2, rs4880; CAT, rs1001179; GPX1, rs17080528; GPX3, rs870406: GPX4, rs713041) were inquired. In addition, some genes involved in CKD (AGT, rs5050; GLO1, rs386572987; SHROOM3, rs17319721) were also evaluated. The genomic damage, the genomic instability, and oxidative damage were evaluated by using the micronucleus and the comet assay in 589 donors (415 CKD patients and 174 controls). Our results showed significant associations between genomic damage and genes directly involved in DNA repair pathways (XRCC1, and ERCC2), and with genes encoding for antioxidant enzymes (SOD1 and GPX1). GSTO2, as a gene involved in phase II metabolism, and MUTYH showed also an association with genomic instability. Interestingly, the three genes associated with CKD (AGT, GLO1, and SHROOM3) showed associations with both the high levels of oxidatively damaged DNA and genomic instability. These results support our view that genomic instability can be considered a biomarker of the CKD status.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653 a CKD patients
653 a Genomic damage
653 a Single nucleotide polymorphisms
7001 a da Silva Filho, Miguel Ináciou German Cancer Research Centre4 aut0 (Swepub:lu)med-md_
7001 a Rodríguez-Ribera, Larau Autonomous University of Barcelona4 aut
7001 a Catalano, Calogerinau German Cancer Research Centre4 aut
7001 a Hemminki, Kariu Lund University,Lunds universitet,Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor,Forskargrupper vid Lunds universitet,Allmänmedicin och klinisk epidemiologi,Family Medicine, Cardiovascular Epidemiology and Lifestyle,Lund University Research Groups,Family Medicine and Clinical Epidemiology,German Cancer Research Centre,Center for Primary Health Care Research4 aut0 (Swepub:lu)med-khk
7001 a Coll, Elisabethu Fundació Puigvert4 aut
7001 a Silva, Ireneu Fundació Puigvert4 aut
7001 a Diaz, Juan Manuelu Fundació Puigvert4 aut
7001 a Ballarin, José Aureliou Fundació Puigvert4 aut
7001 a Henández, Albau Carlos III Health Institute,Autonomous University of Barcelona4 aut
7001 a Försti, Astau Lund University,Lunds universitet,Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor,Forskargrupper vid Lunds universitet,Allmänmedicin och klinisk epidemiologi,Family Medicine, Cardiovascular Epidemiology and Lifestyle,Lund University Research Groups,Family Medicine and Clinical Epidemiology,Center for Primary Health Care Research,German Cancer Research Centre4 aut0 (Swepub:lu)med-asf
7001 a Marcos, Ricardu Carlos III Health Institute,Autonomous University of Barcelona4 aut
7001 a Pastor, Susanau Autonomous University of Barcelona,Carlos III Health Institute4 aut
7102 a Autonomous University of Barcelonab German Cancer Research Centre4 org
7730 t Mutation Research - Genetic Toxicology and Environmental Mutagenesisd : Elsevier BVg 852q 852x 1383-5718
8564 u http://dx.doi.org/10.1016/j.mrgentox.2020.503167y FULLTEXT
8564 8u https://lup.lub.lu.se/record/8625e4b3-5b86-42c9-a8ed-1d2f56000208
8564 8u https://doi.org/10.1016/j.mrgentox.2020.503167

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