WFRF:(Sjögren Klara 1970)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03050naa a2200421 4500 | |
| 001 | oai:gup.ub.gu.se/91422 | |
| 003 | SwePub | |
| 008 | 240528s2000 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/914222 URI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine4 aut0 (Swepub:gu)xohlcl |
| 245 | 1 0 | a The relative importance of endocrine versus autocrine/paracrine insulin-like growth factor-I in the regulation of body growth. |
| 264 | 1 | c 2000 |
| 520 | a Body growth is regulated by growth hormone (GH) and insulin-like growth factor-I (IGF-I). The classical somatomedin hypothesis of this regulation is that most IGF-I in the blood originates in the liver and that body growth is controlled by the concentration of IGF-I in the blood. We have recently abolished IGF-I production in the livers of mice by using the Cre/loxP recombination system. These mice displayed a more than 75% reduction in serum IGF-I associated with increased serum levels of GH. In contrast, they demonstrated a normal postnatal growth, indicating that extrahepatic, autocrine/paracrine-acting IGF-I is the main determinant of postnatal growth. Thus, the "classical" somatomedin hypothesis needs revision. We propose the "dual somatomedin hypothesis" according to which: (1) autocrine/paracrine IGF-I is the main determinant of postnatal body growth and (2) liver-derived, endocrine-acting, IGF-I exerts negative feedback on GH secretion and possibly also exerts other effects on carbohydrate and lipid metabolism. | |
| 653 | a Animals | |
| 653 | a Autocrine Communication | |
| 653 | a physiology | |
| 653 | a Endocrine Glands | |
| 653 | a physiology | |
| 653 | a Growth | |
| 653 | a physiology | |
| 653 | a Growth Hormone | |
| 653 | a physiology | |
| 653 | a Humans | |
| 653 | a Insulin-Like Growth Factor I | |
| 653 | a physiology | |
| 653 | a Paracrine Communication | |
| 653 | a physiology | |
| 700 | 1 | a Sjögren, Klara,d 1970u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine4 aut0 (Swepub:gu)xsjokl |
| 700 | 1 | a Jansson, John-Olov,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine4 aut0 (Swepub:gu)xjanjo |
| 700 | 1 | a Isaksson, Olle,d 1943u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine4 aut0 (Swepub:gu)xisaol |
| 710 | 2 | a Göteborgs universitetb Institutionen för invärtesmedicin, Avdelningen för internmedicin4 org |
| 773 | 0 | t Pediatric nephrology (Berlin, Germany)g 14:7, s. 541-3q 14:7<541-3x 0931-041X |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/91422 |
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