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Sökning: WFRF:(Smith Warner Stephanie A.) > (2005-2009) > Intake of the major...

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FältnamnIndikatorerMetadata
00006463naa a2200649 4500
001oai:DiVA.org:uu-422147
003SwePub
008201013s2006 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:1931357
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4221472 URI
0247 a https://doi.org/10.1002/ijc.220762 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:19313572 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Koushik, Anita4 aut
2451 0a Intake of the major carotenoids and the risk of epithelial ovarian cancer in a pooled analysis of 10 cohort studies
264 c 2006-07-05
264 1a Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA. Harvard Univ, Sch Med, Boston, MA 02115 USA. Harvard Univ, Ctr Canc Prevent, Boston, MA 02115 USA. Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA. Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA. SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY USA. TNO, Qual Life, Dept Food & Chem Risk Anal, NL-3700 AJ Zeist, Netherlands. Karolinska Inst, Natl Inst Environm Med, Div Nutrit Epidemiol, Stockholm, Sweden. NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA. Amer Canc Soc, Epidemiol & Surveillance Res, Atlanta, GA 30329 USA. Univ Toronto, Fac Med, Dept Publ Hlth Sci, Toronto, ON, Canada. Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA. Maastricht Univ, NUTRIM, Dept Epidemiol, Maastricht, Netherlands.b WILEY,c 2006
338 a print2 rdacarrier
520 a Carotenoids, found in fruits and vegetables, have the potential to protect against cancer because of their properties, including their functions as precursors to vitamin A and as antioxidants. We examined the associations between intakes of alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein/zeaxanthin and lycopene and the risk of invasive epithelial ovarian cancer. The primary data from 10 prospective cohort studies in North America and Europe were analyzed and then pooled. Carotenoid intakes were estimated from a validated food frequency questionnaire administered at baseline in each study. Study-specific relative risks (RR) were estimated using the Cox proportional hazards model and then combined using a random-effects model. Among 521,911 women, 2,012 cases of ovarian cancer occurred during a follow-up of 7-22 years across studies. The major carotenoids were not significantly associated with the risk of ovarian cancer. The pooled multivariate RRs (95% confidence intervals) were 1.00 (0.95-1.05) for a 600 mu g/day increase in alpha-carotene intake, 0.96 (0.93-1.03) for a 2,500 mu g/day increase in beta-carotene intake, 0.99 (0.97-1.02) for a 100 mu g/day increase in beta-cryptoxanthin intake, 0.98 (0.94-1.03) for a 2,500 mu g/day increase in lutein/zeaxanthin intake and 1.01 (0.97-1.05) for a 4,000 mu g/day increase in lycopene intake. These associations did not appreciably differ by study (p-values, tests for between-studies heterogeneity > 0.17). Also, the observed associations did not vary substantially by subgroups of the population or by histological type of ovarian cancer. These results suggest that consumption of the major carotenoids during adulthood does not play a major role in the incidence of ovarian cancer. (c) 2006 Wiley-Liss, Inc.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a ovarian cancer
653 a carotenoids
653 a pooled analysis
653 a meta-analysis
653 a cohort studies
7001 a Hunter, David J.4 aut
7001 a Spiegelman, Donna4 aut
7001 a Anderson, Kristin E.4 aut
7001 a Buring, Julie E.4 aut
7001 a Freudenheim, Jo L.4 aut
7001 a Goldbohm, R. Alexandra4 aut
7001 a Hankinson, Susan E.4 aut
7001 a Larsson, Susanna C.u Karolinska Institutet4 aut
7001 a Leitzmann, Michael4 aut
7001 a Marshall, James R.4 aut
7001 a McCullough, Marjorie L.4 aut
7001 a Miller, Anthony B.4 aut
7001 a Rodriguez, Carmen4 aut
7001 a Rohan, Thomas E.4 aut
7001 a Ross, Julie A.4 aut
7001 a Schatzkin, Arthur4 aut
7001 a Schouten, Leo J.4 aut
7001 a Willett, Walter C.4 aut
7001 a Wolk, Alicjau Karolinska Institutet4 aut
7001 a Zhang, Shumin M.4 aut
7001 a Smith-Warner, Stephanie A.4 aut
7102 a Karolinska Institutet4 org
7730 t International Journal of Cancerd Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA. Harvard Univ, Sch Med, Boston, MA 02115 USA. Harvard Univ, Ctr Canc Prevent, Boston, MA 02115 USA. Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA. Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA. SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY USA. TNO, Qual Life, Dept Food & Chem Risk Anal, NL-3700 AJ Zeist, Netherlands. Karolinska Inst, Natl Inst Environm Med, Div Nutrit Epidemiol, Stockholm, Sweden. NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA. Amer Canc Soc, Epidemiol & Surveillance Res, Atlanta, GA 30329 USA. Univ Toronto, Fac Med, Dept Publ Hlth Sci, Toronto, ON, Canada. Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA. Maastricht Univ, NUTRIM, Dept Epidemiol, Maastricht, Netherlands. : WILEYg 119:9, s. 2148-2154q 119:9<2148-2154x 0020-7136x 1097-0215
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.22076
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-422147
8564 8u https://doi.org/10.1002/ijc.22076
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:1931357

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