Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

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Fältnamn	Indikatorer	Metadata
000		08837naa a2201801 4500
001		oai:DiVA.org:su-192186
003		SwePub
008		210418s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:kth-307401
009		oai:prod.swepub.kib.ki.se:146056339
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1921862 URI
024	7	a https://doi.org/10.1038/s41591-020-01227-z2 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3074012 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1460563392 URI
040		a (SwePub)sud (SwePub)kthd (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Muus, Christoph4 aut
245	1 0	a Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics
264		c 2021-03-02
264	1	b Springer Science and Business Media LLC,c 2021
338		a print2 rdacarrier
500		a QC 20220124
520		a Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL) are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry, and their expression may shed light on viral tropism and impact across the body. We assessed the cell-type-specific expression of ACE2, TMPRSS2 and CTSL across 107 single-cell RNA-sequencing studies from different tissues. ACE2, TMPRSS2 and CTSL are coexpressed in specific subsets of respiratory epithelial cells in the nasal passages, airways and alveoli, and in cells from other organs associated with coronavirus disease 2019 (COVID-19) transmission or pathology. We performed a meta-analysis of 31 lung single-cell RNA-sequencing studies with 1,320,896 cells from 377 nasal, airway and lung parenchyma samples from 228 individuals. This revealed cell-type-specific associations of age, sex and smoking with expression levels of ACE2, TMPRSS2 and CTSL. Expression of entry factors increased with age and in males, including in airway secretory cells and alveolar type 2 cells. Expression programs shared by ACE2(+)TMPRSS2(+) cells in nasal, lung and gut tissues included genes that may mediate viral entry, key immune functions and epithelial-macrophage cross-talk, such as genes involved in the interleukin-6, interleukin-1, tumor necrosis factor and complement pathways. Cell-type-specific expression patterns may contribute to the pathogenesis of COVID-19, and our work highlights putative molecular pathways for therapeutic intervention. An integrated analysis of over 100 single-cell and single-nucleus transcriptomics studies illustrates severe acute respiratory syndrome coronavirus 2 viral entry gene coexpression patterns across different human tissues, and shows association of age, smoking status and sex with viral entry gene expression in respiratory cell populations.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
700	1	a Luecken, Malte D.4 aut
700	1	a Eraslan, Gokcen4 aut
700	1	a Sikkema, Lisa4 aut
700	1	a Waghray, Avinash4 aut
700	1	a Heimberg, Graham4 aut
700	1	a Kobayashi, Yoshihiko4 aut
700	1	a Vaishnav, Eeshit Dhaval4 aut
700	1	a Subramanian, Ayshwarya4 aut
700	1	a Smillie, Christopher4 aut
700	1	a Jagadeesh, Karthik A.4 aut
700	1	a Duong, Elizabeth Thu4 aut
700	1	a Fiskin, Evgenij4 aut
700	1	a Triglia, Elena Torlai4 aut
700	1	a Ansari, Meshal4 aut
700	1	a Cai, Peiwen4 aut
700	1	a Lin, Brian4 aut
700	1	a Buchanan, Justin4 aut
700	1	a Chen, Sijia4 aut
700	1	a Shu, Jian4 aut
700	1	a Larsson, Ludvigu KTH,Genteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u13lw4hm
700	1	a Chung, Hattie4 aut
700	1	a Montoro, Daniel T.4 aut
700	1	a Adams, Taylor4 aut
700	1	a Aliee, Hananeh4 aut
700	1	a Allon, Samuel J.4 aut
700	1	a Andrusivova, Zanetau KTH,Science for Life Laboratory, SciLifeLab,Genteknologi4 aut0 (Swepub:kth)u147zn3v
700	1	a Angelidis, Ilias4 aut
700	1	a Ashenberg, Orr4 aut
700	1	a Bassler, Kevin4 aut
700	1	a Becavin, Christophe4 aut
700	1	a Benhar, Inbal4 aut
700	1	a Bergenstråhle, Josephu KTH,Genteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1ck6nue
700	1	a Bergenstråhle, Ludvigu KTH,Genteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1f4ltny
700	1	a Bolt, Liam4 aut
700	1	a Braun, Emelie4 aut
700	1	a Bui, Linh T.4 aut
700	1	a Callori, Steven4 aut
700	1	a Chaffin, Mark4 aut
700	1	a Chichelnitskiy, Evgeny4 aut
700	1	a Chiou, Joshua4 aut
700	1	a Conlon, Thomas M.4 aut
700	1	a Cuoco, Michael S.4 aut
700	1	a Cuomo, Anna S. E.4 aut
700	1	a Deprez, Marie4 aut
700	1	a Duclos, Grant4 aut
700	1	a Fine, Denise4 aut
700	1	a Fischer, David S.4 aut
700	1	a Ghazanfar, Shila4 aut
700	1	a Gillich, Astrid4 aut
700	1	a Giotti, Bruno4 aut
700	1	a Gould, Joshua4 aut
700	1	a Guo, Minzhe4 aut
700	1	a Gutierrez, Austin J.4 aut
700	1	a Habermann, Arun C.4 aut
700	1	a Harvey, Tyler4 aut
700	1	a He, Peng4 aut
700	1	a Hou, Xiaomeng4 aut
700	1	a Hu, Lijuan4 aut
700	1	a Hu, Yan4 aut
700	1	a Jaiswal, Alok4 aut
700	1	a Ji, Lu4 aut
700	1	a Jiang, Peiyong4 aut
700	1	a Kapellos, Theodoros S.4 aut
700	1	a Kuo, Christin S.4 aut
700	1	a Larsson, Ludvig4 aut
700	1	a Leney-Greene, Michael A.4 aut
700	1	a Lim, Kyungtae4 aut
700	1	a Litvinukova, Monika4 aut
700	1	a Ludwig, Leif S.4 aut
700	1	a Lukassen, Soeren4 aut
700	1	a Luo, Wendy4 aut
700	1	a Maatz, Henrike4 aut
700	1	a Madissoon, Elo4 aut
700	1	a Mamanova, Lira4 aut
700	1	a Manakongtreecheep, Kasidet4 aut
700	1	a Leroy, Sylvie4 aut
700	1	a Mayr, Christoph H.4 aut
700	1	a Mbano, Ian M.4 aut
700	1	a McAdams, Alexi M.4 aut
700	1	a Nabhan, Ahmad N.4 aut
700	1	a Nyquist, Sarah K.4 aut
700	1	a Penland, Lolita4 aut
700	1	a Poirion, Olivier B.4 aut
700	1	a Poli, Sergio4 aut
700	1	a Qi, CanCan4 aut
700	1	a Queen, Rachel4 aut
700	1	a Reichart, Daniel4 aut
700	1	a Rosas, Ivan4 aut
700	1	a Schupp, Jonas C.4 aut
700	1	a Shea, Conor4 aut
700	1	a Shi, Xingyi4 aut
700	1	a Sinha, Rahul4 aut
700	1	a Sit, Rene4 aut
700	1	a Slowikowski, Kamil4 aut
700	1	a Slyper, Michal4 aut
700	1	a Smith, Neal P.4 aut
700	1	a Sountoulidis, Alexu Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)asoun
700	1	a Strunz, Maximilian4 aut
700	1	a Sullivan, Travis B.4 aut
700	1	a Sun, Dawei4 aut
700	1	a Talavera-Lopez, Carlos4 aut
700	1	a Tan, Peng4 aut
700	1	a Tantivit, Jessica4 aut
700	1	a Travaglini, Kyle J.4 aut
700	1	a Tucker, Nathan R.4 aut
700	1	a Vernon, Katherine A.4 aut
700	1	a Wadsworth, Marc H.4 aut
700	1	a Waldman, Julia4 aut
700	1	a Wang, Xiuting4 aut
700	1	a Xu, Ke4 aut
700	1	a Yan, Wenjun4 aut
700	1	a Zhao, William4 aut
700	1	a Ziegler, Carly G. K.4 aut
710	2	a KTHb Genteknologi4 org
773	0	t Nature Medicined : Springer Science and Business Media LLCg 27:3, s. 546-559q 27:3<546-559x 1078-8956x 1546-170X
856	4	u https://doi.org/10.1038/s41591-020-01227-zy Fulltext
856	4	u https://www.nature.com/articles/s41591-020-01227-z.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-192186
856	4 8	u https://doi.org/10.1038/s41591-020-01227-z
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-307401
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:146056339

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Av författaren/redakt...: Muus, Christoph; Luecken, Malte D ...; Eraslan, Gokcen; Sikkema, Lisa; Waghray, Avinash; Heimberg, Graham; visa fler...; Kobayashi, Yoshi ...; Vaishnav, Eeshit ...; Subramanian, Ays ...; Smillie, Christo ...; Jagadeesh, Karth ...; Duong, Elizabeth ...; Fiskin, Evgenij; Triglia, Elena T ...; Ansari, Meshal; Cai, Peiwen; Lin, Brian; Buchanan, Justin; Chen, Sijia; Shu, Jian; Larsson, Ludvig; Chung, Hattie; Montoro, Daniel ...; Adams, Taylor; Aliee, Hananeh; Allon, Samuel J.; Andrusivova, Zan ...; Angelidis, Ilias; Ashenberg, Orr; Bassler, Kevin; Becavin, Christo ...; Benhar, Inbal; Bergenstråhle, ...; Bergenstråhle, L ...; Bolt, Liam; Braun, Emelie; Bui, Linh T.; Callori, Steven; Chaffin, Mark; Chichelnitskiy, ...; Chiou, Joshua; Conlon, Thomas M ...; Cuoco, Michael S ...; Cuomo, Anna S. E ...; Deprez, Marie; Duclos, Grant; Fine, Denise; Fischer, David S ...; Ghazanfar, Shila; Gillich, Astrid; Giotti, Bruno; Gould, Joshua; Guo, Minzhe; Gutierrez, Austi ...; Habermann, Arun ...; Harvey, Tyler; He, Peng; Hou, Xiaomeng; Hu, Lijuan; Hu, Yan; Jaiswal, Alok; Ji, Lu; Jiang, Peiyong; Kapellos, Theodo ...; Kuo, Christin S.; Leney-Greene, Mi ...; Lim, Kyungtae; Litvinukova, Mon ...; Ludwig, Leif S.; Lukassen, Soeren; Luo, Wendy; Maatz, Henrike; Madissoon, Elo; Mamanova, Lira; Manakongtreechee ...; Leroy, Sylvie; Mayr, Christoph ...; Mbano, Ian M.; McAdams, Alexi M ...; Nabhan, Ahmad N.; Nyquist, Sarah K ...; Penland, Lolita; Poirion, Olivier ...; Poli, Sergio; Qi, CanCan; Queen, Rachel; Reichart, Daniel; Rosas, Ivan; Schupp, Jonas C.; Shea, Conor; Shi, Xingyi; Sinha, Rahul; Sit, Rene; Slowikowski, Kam ...; Slyper, Michal; Smith, Neal P.; Sountoulidis, Al ...; Strunz, Maximili ...; Sullivan, Travis ...; Sun, Dawei; Talavera-Lopez, ...; Tan, Peng; Tantivit, Jessic ...; Travaglini, Kyle ...; Tucker, Nathan R ...; Vernon, Katherin ...; Wadsworth, Marc ...; Waldman, Julia; Wang, Xiuting; Xu, Ke; Yan, Wenjun; Zhao, William; Ziegler, Carly G ...; visa färre...

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