Sökning: WFRF:(Sun Xi) > Genome-wide associa...
Fältnamn | Indikatorer | Metadata |
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000 | 04542naa a2201081 4500 | |
001 | oai:DiVA.org:umu-76258 | |
003 | SwePub | |
008 | 130708s2013 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-762582 URI |
024 | 7 | a https://doi.org/10.1038/ng.26272 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Deng, Min4 aut |
245 | 1 0 | a Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis |
264 | c 2013-04-28 | |
264 | 1 | b Nature Publishing Group,c 2013 |
338 | a print2 rdacarrier | |
520 | a To identify susceptibility genes for amyotrophic lateral sclerosis (ALS), we conducted a genome-wide association study (GWAS) in 506 individuals with sporadic ALS and 1,859 controls of Han Chinese ancestry. Ninety top SNPs suggested by the current GWAS and 6 SNPs identified by previous GWAS were analyzed in an independent cohort of 706 individuals with ALS and 1,777 controls of Han Chinese ancestry. We discovered two new susceptibility loci for ALS at 1q32 (CAMK1G, rs6703183, P-combined = 2.92 x 10(-8), odds ratio (OR) = 1.31) and 22p11 (CABIN1 and SUSD2, rs8141797, P-combined = 2.35 x 10(-9), OR = 1.52). These two loci explain 12.48% of the overall variance in disease risk in the Han Chinese population. We found no association evidence for the previously reported loci in the Han Chinese population, suggesting genetic heterogeneity of disease susceptibility for ALS between ancestry groups. Our study identifies two new susceptibility loci and suggests new pathogenic mechanisms of ALS. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Wei, Ling4 aut |
700 | 1 | a Zuo, Xianbo4 aut |
700 | 1 | a Tian, Yanghua4 aut |
700 | 1 | a Xie, Fei4 aut |
700 | 1 | a Hu, Panpan4 aut |
700 | 1 | a Zhu, Chunyan4 aut |
700 | 1 | a Yu, Fengqiong4 aut |
700 | 1 | a Meng, Yu4 aut |
700 | 1 | a Wang, Honghao4 aut |
700 | 1 | a Zhang, Fangfang4 aut |
700 | 1 | a Ma, Huijuan4 aut |
700 | 1 | a Ye, Rong4 aut |
700 | 1 | a Cheng, Huaidong4 aut |
700 | 1 | a Du, Jing4 aut |
700 | 1 | a Dong, Wenwen4 aut |
700 | 1 | a Zhou, Shanshan4 aut |
700 | 1 | a Wang, Changqing4 aut |
700 | 1 | a Wang, Yu4 aut |
700 | 1 | a Wang, Jingye4 aut |
700 | 1 | a Chen, Xianwen4 aut |
700 | 1 | a Sun, Zhongwu4 aut |
700 | 1 | a Zhou, Nong4 aut |
700 | 1 | a Jiang, Yubao4 aut |
700 | 1 | a Liu, Xiuxiu4 aut |
700 | 1 | a Li, Xiaogang4 aut |
700 | 1 | a Zhang, Nan4 aut |
700 | 1 | a Liu, Na4 aut |
700 | 1 | a Guan, Yingjun4 aut |
700 | 1 | a Han, Yongsheng4 aut |
700 | 1 | a Han, Yongzhu4 aut |
700 | 1 | a Lv, Xinyi4 aut |
700 | 1 | a Fu, Yu4 aut |
700 | 1 | a Yu, Hui4 aut |
700 | 1 | a Xi, Chunhua4 aut |
700 | 1 | a Xie, Dandan4 aut |
700 | 1 | a Zhao, Qiyuan4 aut |
700 | 1 | a Xie, Peng4 aut |
700 | 1 | a Wang, Xin4 aut |
700 | 1 | a Zhang, Zhijun4 aut |
700 | 1 | a Shen, Lu4 aut |
700 | 1 | a Cui, Yong4 aut |
700 | 1 | a Yin, Xianyong4 aut |
700 | 1 | a Cheng, Hui4 aut |
700 | 1 | a Liang, Bo4 aut |
700 | 1 | a Zheng, Xiaodong4 aut |
700 | 1 | a Lee, Tatia M. C.4 aut |
700 | 1 | a Chen, Gang4 aut |
700 | 1 | a Zhou, Fusheng4 aut |
700 | 1 | a Veldink, Jan H.4 aut |
700 | 1 | a Robberecht, Wim4 aut |
700 | 1 | a Landers, John E.4 aut |
700 | 1 | a Andersen, Peter M.u Umeå universitet,Klinisk neurovetenskap4 aut0 (Swepub:umu)pean0001 |
700 | 1 | a Al-Chalabi, Ammar4 aut |
700 | 1 | a Shaw, Chris4 aut |
700 | 1 | a Liu, Chunfeng4 aut |
700 | 1 | a Tang, Beisha4 aut |
700 | 1 | a Xiao, Shangxi4 aut |
700 | 1 | a Robertson, Janice4 aut |
700 | 1 | a Zhang, Fengyu4 aut |
700 | 1 | a van den Berg, Leonard H.4 aut |
700 | 1 | a Sun, Liangdan4 aut |
700 | 1 | a Liu, Jianjun4 aut |
700 | 1 | a Yang, Sen4 aut |
700 | 1 | a Ju, Xiaodong4 aut |
700 | 1 | a Wang, Kai4 aut |
700 | 1 | a Zhang, Xuejun4 aut |
710 | 2 | a Umeå universitetb Klinisk neurovetenskap4 org |
773 | 0 | t Nature Geneticsd : Nature Publishing Groupg 45:6, s. 697-+q 45:6<697-+x 1061-4036x 1546-1718 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-76258 |
856 | 4 8 | u https://doi.org/10.1038/ng.2627 |
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