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Helicobacter pylori...
Helicobacter pylori and Pro-Inflammatory Protein Biomarkers in Myocardial Infarction with and without Obstructive Coronary Artery Disease
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- Warme, Jonatan (författare)
- Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, SE-11883 Stockholm, Sweden.;Soder Sjukhuset, Dept Cardiol, SE-11883 Stockholm, Sweden.
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- Sundqvist, Martin O. (författare)
- Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, SE-11883 Stockholm, Sweden.;Soder Sjukhuset, Dept Cardiol, SE-11883 Stockholm, Sweden.
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- Hjort, Marcus (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för medicinska vetenskaper
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- Agewall, Stefan (författare)
- Univ Oslo, Inst Clin Med, Div Med, NO-0318 Oslo, Norway.;Oslo Univ Hosp, Dept Cardiol, NO-0450 Oslo, Norway.
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- Collste, Olov (författare)
- Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, SE-11883 Stockholm, Sweden.;Soder Sjukhuset, Dept Cardiol, SE-11883 Stockholm, Sweden.
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- Ekenback, Christina (författare)
- Karolinska Institutet,Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, SE-18288 Stockholm, Sweden.
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- Frick, Mats (författare)
- Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, SE-11883 Stockholm, Sweden.;Soder Sjukhuset, Dept Cardiol, SE-11883 Stockholm, Sweden.
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- Henareh, Loghman (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Huddinge, SE-14186 Huddinge, Sweden.;Karolinska Univ Hosp, Coronary Artery Dis Area, Heart & Vasc Theme, SE-17176 Stockholm, Sweden.
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- Hofman-Bang, Claes (författare)
- Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, SE-18288 Stockholm, Sweden.
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- Spaak, Jonas (författare)
- Karolinska Institutet,Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, SE-18288 Stockholm, Sweden.
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- Sorensson, Peder (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Coronary Artery Dis Area, Heart & Vasc Theme, SE-17176 Stockholm, Sweden.;Karolinska Inst, Dept Med Solna, SE-17176 Stockholm, Sweden.
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- Y-Hassan, Shams (författare)
- Karolinska Inst, Dept Med Huddinge, SE-14186 Huddinge, Sweden.;Karolinska Univ Hosp, Coronary Artery Dis Area, Heart & Vasc Theme, SE-17176 Stockholm, Sweden.
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- Svensson, Per (författare)
- Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, SE-11883 Stockholm, Sweden.;Soder Sjukhuset, Dept Cardiol, SE-11883 Stockholm, Sweden.
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- Lindahl, Bertil, 1957- (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR),Uppsala Univ, Dept Med Sci, Uppsala SE-75185, Sweden.;Uppsala Univ, Uppsala Clin Res Ctr, SE-75185 Uppsala, Sweden.
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- Hofmann, Robin (författare)
- Karolinska Institutet,Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, SE-11883 Stockholm, Sweden.;Soder Sjukhuset, Dept Cardiol, SE-11883 Stockholm, Sweden.
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- Tornvall, Per (författare)
- Karolinska Institutet,Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, SE-11883 Stockholm, Sweden.;Soder Sjukhuset, Dept Cardiol, SE-11883 Stockholm, Sweden.
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Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, SE-11883 Stockholm, Sweden;Soder Sjukhuset, Dept Cardiol, SE-11883 Stockholm, Sweden. Uppsala kliniska forskningscentrum (UCR) (creator_code:org_t)
- MDPI AG, 2023
- 2023
- Engelska.
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Ingår i: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 44
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Myocardial infarction (MI) with obstructive coronary artery disease (MI-CAD) and MI in the absence of obstructive coronary artery disease (MINOCA) affect different populations and may have separate pathophysiological mechanisms, with greater inflammatory activity in MINOCA compared to MI-CAD. Helicobacter pylori (Hp) can cause systemic inflammation and has been associated with cardiovascular disease (CVD). We aimed to investigate whether Hp infection is associated with concentrations of protein biomarkers of inflammation and CVD. In a case-control study, patients with MINOCA (n = 99) in Sweden were included, complemented by matched subjects with MI-CAD (n = 99) and controls (n = 100). Protein biomarkers were measured with a proximity extension assay in plasma samples collected 3 months after MI. The seroprevalence of Hp and cytotoxin-associated gene A (CagA) was determined using ELISA. The associations between protein levels and Hp status were studied with linear regression. The prevalence of Hp was 20.2%, 19.2%, and 16.0% for MINOCA, MI-CAD, and controls, respectively (p = 0.73). Seven proteins were associated with Hp in an adjusted model: tissue plasminogen activator (tPA), interleukin-6 (IL-6), myeloperoxidase (MPO), TNF-related activation-induced cytokine (TRANCE), pappalysin-1 (PAPPA), soluble urokinase plasminogen activator receptor (suPAR), and P-selectin glycoprotein ligand 1 (PSGL-1). Hp infection was present in one in five patients with MI, irrespective of the presence of obstructive CAD. Inflammatory proteins were elevated in Hp-positive subjects, thus not ruling out that Hp may promote an inflammatory response and potentially contribute to the development of CVD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- myocardial infarction
- coronary artery disease
- MINOCA
- Helicobacter pylori
- inflammation
- biomarkers
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Warme, Jonatan
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Sundqvist, Marti ...
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Hjort, Marcus
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Agewall, Stefan
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Collste, Olov
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Ekenback, Christ ...
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visa fler...
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Frick, Mats
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Henareh, Loghman
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Hofman-Bang, Cla ...
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Spaak, Jonas
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Sorensson, Peder
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Y-Hassan, Shams
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Svensson, Per
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Lindahl, Bertil, ...
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Hofmann, Robin
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Tornvall, Per
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