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Sökning: WFRF:(Svensson Marie Louise) > (2020-2024) > Splenic flexure mob...

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FältnamnIndikatorerMetadata
00006587naa a2200841 4500
001oai:gup.ub.gu.se/331775
003SwePub
008240910s2023 | |||||||||||000 ||eng|
009oai:DiVA.org:oru-108193
009oai:DiVA.org:umu-214537
009oai:prod.swepub.kib.ki.se:153683603
009oai:lup.lub.lu.se:8e109d25-4370-4ebb-9087-111be2e4303c
0247 a https://gup.ub.gu.se/publication/3317752 URI
0247 a https://doi.org/10.1177/145749692311812222 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1081932 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2145372 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1536836032 URI
0247 a https://lup.lub.lu.se/record/8e109d25-4370-4ebb-9087-111be2e4303c2 URI
040 a (SwePub)gud (SwePub)orud (SwePub)umud (SwePub)kid (SwePub)lu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Rutegård, Martin,d 1982-u Umeå University,Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Institutionen för kirurgisk och perioperativ vetenskap4 aut0 (Swepub:umu)maru0039
2451 0a Splenic flexure mobilization and anastomotic leakage in anterior resection for rectal cancer: A multicentre cohort study.
264 1b Sage Publications,c 2023
500 a Funding agencies:Cancer Research Foundation in Northern Sweden AMP 19-978Bengt Ihre Foundation SLS-934603 
520 a Some colorectal surgeons advocate routine splenic flexure mobilization (SFM) when performing anterior resection for rectal cancer to ensure a tension-free anastomosis. Meta-analyses of smaller studies suggest that this approach does not influence anastomotic leakage rates, but larger multicentre studies are needed to confirm the safety of a selective strategy. The aim of this study is to evaluate the impact of SFM on anastomotic leakage.This is a retrospective multicentre cohort study, comprising 1109 patients operated with anterior resection for rectal cancer in 2014-2018. Exposure was SFM, while anastomotic leakage within a year constituted the outcome. Stratified analyses were performed for type of mesorectal excision and surgical approach, as well as sensitivity analysis considering vascular tie placement. Multivariable Cox regression with hazard ratios (HRs) and 95% confidence intervals (CIs) was employed to adjust for confounding, while multiple imputation was used for missing data.SFM was performed in 381 patients (34.4%). Anastomotic leakage occurred in 83 (21.8%) and 123 (20.3%) patients operated with and without SFM, respectively. SFM was neither clearly detrimental nor beneficial regarding anastomotic leakage (adjusted HR = 0.82; 95% CI: 0.59-1.15), with no apparent differences for total or partial mesorectal excision and minimally invasive or open surgery. Concurrent high vascular ligation did not impact these results, and there was no evidence of interaction from centers with a more common use of SFM.SFM did not seem to influence the risk of anastomotic leakage after anterior resection for rectal cancer, regardless of type of mesorectal excision, use of minimally invasive surgery, or high vascular ligation.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Humans
653 a Anastomotic Leak
653 a epidemiology
653 a etiology
653 a Colon
653 a Transverse
653 a surgery
653 a Cohort Studies
653 a Rectal Neoplasms
653 a surgery
653 a Anastomosis
653 a Surgical
653 a adverse effects
653 a methods
653 a Retrospective Studies
653 a Rectum
653 a surgery
653 a Insufficiency
653 a adenocarcinoma
653 a dehiscence
653 a Insufficiency
653 a leak
653 a rectum
653 a splenic flexure
7001 a Svensson, Johan,d 1978-u Umeå University,Umeå universitet,Statistik4 aut0 (Swepub:umu)josv0027
7001 a Segelman, Josefinu Karolinska Institute,Karolinska Institutet,Ersta Hospital4 aut
7001 a Matthiessen, Peter,d 1957-u Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden4 aut0 (Swepub:oru)pemn
7001 a Lydrup, Marie Louiseu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments4 aut0 (Swepub:lu)med-msl
7001 a Park, Jenniferu Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Department of Surgery, Scandinavian Surgical Outcomes Research Group (SSORG), Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:gu)xparje
7001 a RectoLeak study group, -4 ctb
7102 a Umeå universitetb Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)4 org
7730 t Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Societyd : Sage Publicationsg 112:4, s. 246-255q 112:4<246-255x 1457-4969x 1799-7267
8564 u https://doi.org/10.1177/14574969231181222y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1800302/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print
8564 u http://dx.doi.org/10.1177/14574969231181222x freey FULLTEXT
8564 8u https://gup.ub.gu.se/publication/331775
8564 8u https://doi.org/10.1177/14574969231181222
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-108193
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-214537
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:153683603
8564 8u https://lup.lub.lu.se/record/8e109d25-4370-4ebb-9087-111be2e4303c

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