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Leisure-time physic...
Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia
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- Tolppanen, Anna-Maija (författare)
- University of Eastern Finland, Kuopio, Finland
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- Solomon, Alina (författare)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),University of Eastern Finland, Finland; Karolinska Institutet, Sweden,Univ Eastern Finland, Kuopio, Finland; Karolinska inst., Stockholm, Sweden; Stockholm univ, Stockholm, Sweden
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- Kulmala, Jenni (författare)
- Karolinska Institutet
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visa fler...
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- Kåreholt, Ingemar (författare)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Jönköping University, Sweden,HHJ, Institutet för gerontologi,Karolinska inst., Stockholm, Sweden; Stockholm univ., Stockholm, Sweden
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- Ngandu, Tiia (författare)
- Karolinska Institutet
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- Rusanen, Minna (författare)
- University of Eastern Finland, Kuopio, Finland
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- Laatikainen, Tiina (författare)
- National Institute for Health and Welfare, Helsinki, Finland; University of Eastern Finland, Kuopio, Finland; Hospital District of North Karelia, Joensuu, Finland
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- Soininen, Hilkka (författare)
- University of Eastern Finland, Kuopio, Finland; Kuopio University Hospital, Kuopio, Finland
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- Kivipelto, Miia (författare)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),University of Eastern Finland, Kuopio, Finland; Karolinska Institutet, Stockholm, Sweden; Stockholm University, Stockholm, Sweden; National Institute for Health and Welfare, Helsinki, Finland
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(creator_code:org_t)
- 2014-04-09
- 2015
- Engelska.
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Ingår i: Alzheimer's & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 11:4, s. 434-443
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Physical activity may be beneficial for cognition, but the effect may vary depending on personal characteristics. Methods: We investigated the associations between leisure-time physical activity (LTPA) from mid- to late life, the risk of dementia, and the role of body mass index, sex, and APOE in the CALDE study during 28-year follow-up. Cognitive function of a random subsample was assessed at a mean age of 78.8 years (n = 1511), and dementia/Alzheimer's disease (AD) diagnoses were identified from national registers for the entire target population (n = 3559). Results: Moderate (hazard ratio [HR], 1.46; 95% confidence interval [CI], 1.08-1.99) and low levels of midlife LTPA (BR, 1.39; 95% CI, 0.99-1.95) were associated with higher risk of dementia in comparison with the most active category. The benefits were more pronounced among men, overweight individuals, and APOE epsilon 4 noncarriers. Maintaining high LTPA (HR, 0.16; 95% CI, 0.06-0.41) or increasing LTPA (HR, 0.19; 95% CI, 0.09-0.40) after midlife was associated with lower dementia risk Similar results were observed for AD. Conclusions: The window of opportunity for preventive physical activity interventions may extend from midlife to older ages.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Nyckelord
- Cohort study
- Dementia
- Exercise
- Life course
- Obesity
- Physical activity
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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