Reduced transforming growth factor-beta1 production by mononuclear cells from patients with active chronic idiopathic thrombocytopenic purpura.

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Fältnamn	Indikatorer	Metadata
000		03716naa a2200529 4500
001		oai:gup.ub.gu.se/197820
003		SwePub
008		240528s2002 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:research.chalmers.se:21b227c1-9ae9-4121-8804-a7956ffa0a29
024	7	a https://gup.ub.gu.se/publication/1978202 URI
024	7	a https://research.chalmers.se/publication/1978202 URI
040		a (SwePub)gud (SwePub)cth
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Andersson, Per-Ola,d 1964u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine,University of Gothenburg4 aut0 (Swepub:gu)xapert
245	1 0	a Reduced transforming growth factor-beta1 production by mononuclear cells from patients with active chronic idiopathic thrombocytopenic purpura.
264	1	c 2002
520		a Chronic idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder in which activated T-helper (Th) cells and different Th-cell cytokines might play an important role. We have recently reported that chronic ITP patients in remission had elevated plasma levels of the Th3 cytokine transforming growth factor-beta1 (TGF-beta1), possibly as a part of a bystander immune suppression. In the present study we found that, in ITP patients with active disease [platelet count (plc) < 50 x 10(9)/l], mitogen-stimulated peripheral blood mononuclear cells (PBMC) had a significantly reduced production of TGF-beta1 (444 +/- 178 pg/ml; n = 6) compared with patients with plc 50-150 x 10(9)/l (1293 +/- 374 pg/ml; n = 9; P < 0.05), patients with plc >150 x 10(9)/l (1894 +/- 244 pg/ml; n =12; P <0.005) and healthy controls (1698 +/- 241 pg/ml; n = 10; P < 0.01). Nineteen per cent of ITP patients expressed a platelet-induced PBMC proliferation. Surprisingly, 22% of the ITP patients had a PBMC proliferation below the normal range, i.e. a suppressed proliferation in the presence of platelets; five of these six patients had active disease. In summary, this study demonstrated that chronic ITP patients with active disease had reduced PBMC production of the Th3 cytokine TGF-beta1. This result gives further support to the theory that chronic ITP in active phase is associated with a downregulated Th3-response.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653		a Acute Disease
653		a Biological Assay
653		a Blood Platelets
653		a Case-Control Studies
653		a Cell Division
653		a Cells
653		a Cultured
653		a Leukocytes
653		a Mononuclear
653		a secretion
653		a Mitogens
653		a pharmacology
653		a Purpura
653		a Thrombocytopenic
653		a Idiopathic
653		a immunology
653		a Transforming Growth Factor beta
653		a secretion
653		a Mononuclear
700	1	a Olsson, Anna,d 19854 aut
700	1	a Wadenvik, Hans,d 1955u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine,University of Gothenburg4 aut0 (Swepub:gu)xwadha
710	2	a Göteborgs universitetb Institutionen för invärtesmedicin, Avdelningen för internmedicin4 org
773	0	t British journal of haematologyg 116:4, s. 862-7q 116:4<862-7x 0007-1048x 1365-2141
856	4 8	u https://gup.ub.gu.se/publication/197820
856	4 8	u https://research.chalmers.se/publication/197820

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Av författaren/redakt...: Andersson, Per-O ...; Olsson, Anna, 19 ...; Wadenvik, Hans, ...

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