WFRF:(Wang Yusheng)
Sökning: WFRF:(Wang Yusheng) > LFA-1 AND MAC-1 MED...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03447naa a2200337 4500 | |
| 001 | oai:lup.lub.lu.se:e7aa3837-e525-40ef-b5a8-8e3fbfb9ddac | |
| 003 | SwePub | |
| 008 | 160404s2008 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/10213612 URI |
| 024 | 7 | a https://doi.org/10.1097/shk.0b013e318162c5672 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Asaduzzaman, Muhammad4 aut |
| 245 | 1 0 | a LFA-1 AND MAC-1 MEDIATE PULMONARY RECRUITMENT OF NEUTROPHILS AND TISSUE DAMAGE IN ABDOMINAL SEPSIS. |
| 264 | 1 | b Ovid Technologies (Wolters Kluwer Health),c 2008 |
| 520 | a Neutrophil-mediated lung damage is an insidious feature in septic patients, although the adhesive mechanisms behind pulmonary recruitment of neutrophils in polymicrobial sepsis remain elusive. The aim of the present study was to define the role of lymphocyte function-antigen 1 (LFA-1) and membrane-activated complex 1 (Mac-1) in septic lung injury. Pulmonary edema, bronchoalveolar infiltration of neutrophils, levels of myeloperoxidase, and CXC chemokines were determined after cecal ligation and puncture (CLP). Mice were treated with monoclonal antibodies directed against LFA-1 and Mac-1 before CLP induction. Cecal ligation and puncture induced clear-cut pulmonary damage characterized by edema formation, neutrophil infiltration, and increased levels of CXC chemokines in the lung. Notably, immunoneutralization of LFA-1 or Mac-1 decreased CLP-induced neutrophil recruitment in the bronchoalveolar space by more than 64%. Moreover, functional inhibition of LFA-1 and Mac-1 abolished CLP-induced lung damage and edema. However, formation of CXC chemokines in the lung was intact in mice pretreated with the anti-LFA-1 and anti-Mac-1 antibodies. Our data demonstrate that both LFA-1 and Mac-1 regulate pulmonary infiltration of neutrophils and lung edema associated with abdominal sepsis. Thus, these novel findings suggest that LFA-1 or Mac-1 may serve as targets to protect against lung injury in polymicrobial sepsis. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 700 | 1 | a Zhang, Suu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)med-sza |
| 700 | 1 | a Lavasani, Shahramu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)infl-sl8 |
| 700 | 1 | a Wang, Yushengu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)yu4833wa |
| 700 | 1 | a Thorlacius, Henriku Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)kir-hth |
| 710 | 2 | a Kirurgib Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Shockd : Ovid Technologies (Wolters Kluwer Health)g 30, s. 254-259q 30<254-259x 1540-0514x 1073-2322 |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/18197144?dopt=Abstracty FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1097/shk.0b013e318162c567y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1021361 |
| 856 | 4 8 | u https://doi.org/10.1097/shk.0b013e318162c567 |
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