WFRF:(Warfvinge Gunnar)
Search: WFRF:(Warfvinge Gunnar) > (2005-2009) > Effects of ovariect...
- 8 of 11
- Previous record
- Next record
- To hitlist
Effects of ovariectomy and aging on tooth attachment in female mice assessed by morphometric analysis
-
- Nebel, Daniel (author)
- Malmö högskola,Odontologiska fakulteten (OD)
- Bratthall, Gunilla (author)
-
- Warfvinge, Gunnar (author)
- Malmö högskola,Odontologiska fakulteten (OD)
- show more...
- Nilsson, Bengt-Olof (author)
- show less...
- (creator_code:org_t)
- 2009-07-02
- 2009
- English.
- In: Acta Odontologica Scandinavica. - : Informa Healthcare. - 0001-6357 .- 1502-3850. ; 67:1, s. 8-12
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Objective. Non-human primates, dogs, rats, hamsters and ferrets, have frequently been used as laboratory animals in periodontal biology and pathology. In the past, mice have been used less for this purpose, but nowadays attract a lot of interest because gene knockout and transgenic technologies utilize mice primarily. In this study, we investigate the effects of ovariectomy and aging on tooth attachment in female mice. Material and methods. Eight-week-old mice (n=15) were divided into three experimental groups (control, n=5; sham-operated, n=5; ovariectomy, n=5) and ovaries removed bilaterally. Attachment level, assessed by measuring alveolar bone height and apical termination of the junctional epithelium, was determined 6 weeks post-ovariectomy by digital morphometric analysis in sagittal sections of the mandible. The plasma level of the inflammation marker serum amyloid A (SAA) was determined by ELISA. In another series of experiments, tooth attachment was determined in female mice (n=7) at 8–26 weeks of age. Results. Withdrawal of female sex hormone production by ovariectomy had no effect on alveolar bone height and apical termination of the junctional epithelium. The SAA level in plasma was unaffected by removal of the ovaries, suggesting that systemic inflammation is not induced by ovariectomy. Bone height was similar in mice sacrificed at 8–26 weeks of age and apical termination of the junctional epithelium was at the cemento-enamel junction at all ages. Conclusions. Removal of ovarian production of female sex hormones by ovariectomy has no influence on tooth attachment, and further tooth attachment is preserved with age in female mice.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- morphometry
- mouse
- ovariectomy
- serum amyloid A
- tooth attachment
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Acta Odontologica Scandinavica (Search for host publication in LIBRIS)
To the university's database
- 8 of 11
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Nebel, Daniel
- Bratthall, Gunil ...
- Warfvinge, Gunna ...
- Nilsson, Bengt-O ...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Cell and Molecul ...
- Articles in the publication
- Acta Odontologic ...
- By the university
- Malmö University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
