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Structure of riboso...
Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition
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- Travin, Dmitrii Y. (författare)
- Skolkovo Inst Sci & Technol, Ctr Life Sci, Moscow, Russia;Russian Acad Sci, Inst Gene Biol, Moscow, Russia
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- Watson, Zoe L. (författare)
- Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
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- Metelev, Mikhail (författare)
- Uppsala universitet,Molekylär systembiologi,Skolkovo Inst Sci & Technol, Ctr Life Sci, Moscow, Russia;Russian Acad Sci, Inst Gene Biol, Moscow, Russia
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- Ward, Fred R. (författare)
- Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA
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- Osterman, Ilya A. (författare)
- Skolkovo Inst Sci & Technol, Ctr Life Sci, Moscow, Russia;Lomonosov Moscow State Univ, Dept Chem, Moscow, Russia
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- Khven, Irina M. (författare)
- Lomonosov Moscow State Univ, Dept Chem, Moscow, Russia;Lomonosov Moscow State Univ, Dept Bioengn & Bioinformat, Moscow, Russia
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- Khabibullina, Nelli F. (författare)
- Univ Illinois, Dept Biol Sci, Chicago, IL 60680 USA;Natl Med Res Ctr Phthisiopulmol & Infect Dis, Moscow, Russia
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- Serebryakova, Marina (författare)
- Lomonosov Moscow State Univ, AN Belozersky Inst Physicochem Biol, Moscow, Russia
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- Mergaert, Peter (författare)
- Univ Paris Saclay, CNRS CEA Univ Paris Sud, Inst Integrat Biol Cell, Gif Sur Yvette, France
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- Polikanov, Yury S. (författare)
- Univ Illinois, Dept Biol Sci, Chicago, IL 60680 USA;Univ Illinois, Dept Pharmaceut Sci, Chicago, IL 60607 USA
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- Cate, Jamie H. D. (författare)
- Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA;Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA
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- Severinov, Konstantin (författare)
- Skolkovo Inst Sci & Technol, Ctr Life Sci, Moscow, Russia;Russian Acad Sci, Inst Gene Biol, Moscow, Russia;Rutgers State Univ, Waksman Inst Microbiol, Piscataway, NJ 08901 USA
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(creator_code:org_t)
- 2019-10-08
- 2019
- Engelska.
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Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 10
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Ribosome-synthesized post-translationally modified peptides (RiPPs) represent a rapidly expanding class of natural products with various biological activities. Linear azol(in)e-containing peptides (LAPs) comprise a subclass of RiPPs that display outstanding diversity of mechanisms of action while sharing common structural features. Here, we report the discovery of a new LAP biosynthetic gene cluster in the genome of Rhizobium Pop5, which encodes the precursor peptide and modification machinery of phazolicin (PHZ) - an extensively modified peptide exhibiting narrow-spectrum antibacterial activity against some symbiotic bacteria of leguminous plants. The cryo-EM structure of the Escherichia coli 70S-PHZ complex reveals that the drug interacts with the 23S rRNA and uL4/uL22 proteins and obstructs ribosomal exit tunnel in a way that is distinct from other compounds. We show that the uL4 loop sequence determines the species-specificity of antibiotic action. PHZ expands the known diversity of LAPs and may be used in the future as biocontrol agent for agricultural needs.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
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Travin, Dmitrii ...
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Watson, Zoe L.
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Metelev, Mikhail
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Ward, Fred R.
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Osterman, Ilya A ...
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Khven, Irina M.
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visa fler...
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Khabibullina, Ne ...
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Serebryakova, Ma ...
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Mergaert, Peter
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Polikanov, Yury ...
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Cate, Jamie H. D ...
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Severinov, Konst ...
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