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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004977naa a2200553 4500
001oai:lup.lub.lu.se:0fc86b4d-7bd4-4dec-8a55-0aa277fa584b
003SwePub
008240318s2023 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:155099363
0247 a https://lup.lub.lu.se/record/0fc86b4d-7bd4-4dec-8a55-0aa277fa584b2 URI
0247 a https://doi.org/10.3389/fimmu.2023.13301532 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1550993632 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Collins, Andrew M.u University of New South Wales4 aut
2451 0a AIRR-C IG Reference Sets : curated sets of immunoglobulin heavy and light chain germline genes
264 1c 2023
520 a Introduction: Analysis of an individual’s immunoglobulin (IG) gene repertoire requires the use of high-quality germline gene reference sets. When sets only contain alleles supported by strong evidence, AIRR sequencing (AIRR-seq) data analysis is more accurate and studies of the evolution of IG genes, their allelic variants and the expressed immune repertoire is therefore facilitated. Methods: The Adaptive Immune Receptor Repertoire Community (AIRR-C) IG Reference Sets have been developed by including only human IG heavy and light chain alleles that have been confirmed by evidence from multiple high-quality sources. To further improve AIRR-seq analysis, some alleles have been extended to deal with short 3’ or 5’ truncations that can lead them to be overlooked by alignment utilities. To avoid other challenges for analysis programs, exact paralogs (e.g. IGHV1-69*01 and IGHV1-69D*01) are only represented once in each set, though alternative sequence names are noted in accompanying metadata. Results and discussion: The Reference Sets include less than half the previously recognised IG alleles (e.g. just 198 IGHV sequences), and also include a number of novel alleles: 8 IGHV alleles, 2 IGKV alleles and 5 IGLV alleles. Despite their smaller sizes, erroneous calls were eliminated, and excellent coverage was achieved when a set of repertoires comprising over 4 million V(D)J rearrangements from 99 individuals were analyzed using the Sets. The version-tracked AIRR-C IG Reference Sets are freely available at the OGRDB website (https://ogrdb.airr-community.org/germline_sets/Human) and will be regularly updated to include newly observed and previously reported sequences that can be confirmed by new high-quality data.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
653 a heavy chain
653 a IGHD
653 a IGHJ
653 a IGHV genes
653 a immunoglobulin
653 a light chain
7001 a Ohlin, Matsu Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,LTH profilområde: Teknik för hälsa,LTH profilområden,SciLifeLab Site@Lund,Forskargrupper vid Lunds universitet,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH,LUCC: Lund University Cancer Centre,Other Strong Research Environments,LTH Profile Area: Engineering Health,LTH Profile areas,Faculty of Engineering, LTH,Lund University Research Groups4 aut0 (Swepub:lu)immt-moh
7001 a Corcoran, Martinu Karolinska Institutet,Karolinska Institute4 aut
7001 a Heather, James M.u Massachusetts General Hospital,Harvard Medical School4 aut
7001 a Ralph, Duncanu Fred Hutchinson Cancer Research Center4 aut
7001 a Law, Mansunu Scripps Research Institute4 aut
7001 a Martínez-Barnetche, Jesusu National Institute of Public Health, Mexico4 aut
7001 a Ye, Jian4 aut
7001 a Richardson, Eveu La Jolla Institute for Allergy and Immunology4 aut
7001 a Gibson, William S.4 aut
7001 a Rodriguez, Oscar L.4 aut
7001 a Peres, Ayeletu Bar-Ilan University4 aut
7001 a Yaari, Guru Bar-Ilan University4 aut
7001 a Watson, Corey T.4 aut
7001 a Lees, William D.u Institute for Systems and Computer Engineering, Technology and Science (INESC TEC),Birkbeck, University of London4 aut
7102 a University of New South Walesb Institutionen för immunteknologi4 org
7730 t Frontiers in Immunologyg 14q 14x 1664-3224
8564 u http://dx.doi.org/10.3389/fimmu.2023.1330153x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/0fc86b4d-7bd4-4dec-8a55-0aa277fa584b
8564 8u https://doi.org/10.3389/fimmu.2023.1330153
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:155099363

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