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Effect of Enterohep...
Effect of Enterohepatic Circulation on the Accumulation of Per- and Polyfluoroalkyl Substances : Evidence from Experimental and Computational Studies
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- Cao, Huiming (författare)
- Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, Institute of Environment and Health, Jianghan University, Wuhan, China
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- Zhou, Zhen (författare)
- Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, Institute of Environment and Health, Jianghan University, Wuhan, China; Key Laboratory of Optoelectronic Chemical Materials and Devices, Ministry of Education, School of Chemical and Environmental Engineering, Jianghan University, Wuhan, China
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- Hu, Zhe (författare)
- College of Resources and Environment, Huazhong Agricultural University, Wuhan, China
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- Wei, Cuiyun (författare)
- Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, Institute of Environment and Health, Jianghan University, Wuhan, China; College of Resources and Environment, Huazhong Agricultural University, Wuhan, China
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- Li, Jie (författare)
- College of Resources and Environment, Huazhong Agricultural University, Wuhan, China
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- Wang, Ling (författare)
- Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, Institute of Environment and Health, Jianghan University, Wuhan, China
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- Liu, Guangliang (författare)
- Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, Institute of Environment and Health, Jianghan University, Wuhan, China
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- Zhang, Jie (författare)
- College of Resources and Environment, Huazhong Agricultural University, Wuhan, China
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- Wang, Yawei (författare)
- State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
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- Wang, Thanh, 1979- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre, School of Science and Technology,Örebro universitet, Institutionen för naturvetenskap och teknik
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- Liang, Yong (författare)
- Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, Institute of Environment and Health, Jianghan University, Wuhan, China
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(creator_code:org_t)
- 2022-02-09
- 2022
- Engelska.
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Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 56:5, s. 3214-3224
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The pharmacokinetic characteristics of per- and polyfluoroalkyl substances (PFAS) affect their distribution and bioaccumulation in biological systems. The enterohepatic circulation leads to reabsorption of certain chemicals from bile back into blood and the liver and thus influences their elimination, yet its influence on PFAS bioaccumulation remains unclear. We explored the role of enterohepatic circulation in PFAS bioaccumulation by examining tissue distribution of various PFAS in wild fish and a rat model. Computational models were used to determine the reabsorbed fractions of PFAS by calculating binding affinities of PFAS for key transporter proteins of enterohepatic circulation. The results indicated that higher concentrations were observed in blood, the liver, and bile compared to other tissues for some PFAS in fish. Furthermore, exposure to a PFAS mixture on the rat model showed that the reabsorption phenomenon appeared during 8-12 h for most long-chain PFAS. Molecular docking calculations suggest that PFAS can bind to key transporter proteins via electrostatic and hydrophobic interactions. Further regression analysis adds support to the hypothesis that binding affinity of the apical sodium-dependent bile acid transporter is the most important variable to predict the human half-lives of PFAS. This study demonstrated the critical role of enterohepatic circulation in reabsorption, distribution, and accumulation of PFAS.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Nyckelord
- PFAS
- computational model
- distribution
- enterohepatic circulation
- reabsorption
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- art (ämneskategori)
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Cao, Huiming
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Zhou, Zhen
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Hu, Zhe
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Wei, Cuiyun
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Li, Jie
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Wang, Ling
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Liu, Guangliang
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Zhang, Jie
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Wang, Yawei
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Wang, Thanh, 197 ...
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Liang, Yong
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