Association of maternal prenatal smoking GFI1-locus and cardiometabolic phenotypes in 18,212 adults

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Fältnamn	Indikatorer	Metadata
000		14441naa a2201093 4500
001		oai:DiVA.org:uu-373242
003		SwePub
008		190114s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3732422 URI
024	7	a https://doi.org/10.1016/j.ebiom.2018.10.0662 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Parmar, Priyankau Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland;Univ Oulu, Bioctr Oulu, Oulu, Finland4 aut
245	1 0	a Association of maternal prenatal smoking GFI1-locus and cardiometabolic phenotypes in 18,212 adults
264	1	b Elsevier BV,c 2018
338		a electronic2 rdacarrier
520		a Background: DNA methylation at the GFI1-locus has been repeatedly associated with exposure to smoking from the foetal period onwards. We explored whether DNA methylation may be a mechanism that links exposure to maternal prenatal smoking with offspring's adult cardio-metabolic health. Methods: We meta-analysed the association between DNA methylation at GFI1-locus with maternal prenatal smoking, adult own smoking, and cardio-metabolic phenotypes in 22 population-based studies from Europe, Australia, and USA (n= 18,212). DNA methylation at the GFI1-locus was measured in whole-blood. Multivariable regression models were fitted to examine its association with exposure to prenatal and own adult smoking. DNA methylation levels were analysed in relation to body mass index (BMI), waist circumference (WC), fasting glucose (FG), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), diastolic, and systolic blood pressure (BP). Findings: Lower DNA methylation at three out of eight GFI1-CpGs was associated with exposure to maternal prenatal smoking, whereas, all eight CpGs were associated with adult own smoking. Lower DNA methylation at cg14179389, the strongest maternal prenatal smoking locus, was associated with increased WC and BP when adjusted for sex, age, and adult smoking with Bonferroni-corrected P < 0.012. In contrast, lower DNA methylation at cg09935388, the strongest adult own smoking locus, was associated with decreased BMI, WC, and BP (adjusted 1 x 10(-7) < P < 0.01). Similarly, lower DNA methylation at cg12876356, cg18316974, cg09662411, and cg18146737 was associated with decreased BMI and WC (5 x 10(-8) < P < 0.001). Lower DNA methylation at all the CpGs was consistently associated with higher TG levels. Interpretation: Epigenetic changes at the GFI1 were linked to smoking exposure in-utero/in-adulthood and robustly associated with cardio-metabolic risk factors. Fund: European Union's Horizon 2020 research and innovation programme under grant agreement no. 633595 DynaHEALTH.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Lowry, Estelleu Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland;Univ Oulu, Bioctr Oulu, Oulu, Finland4 aut
700	1	a Cugliari, Giovanniu Univ Turin, Dept Med Sci, Turin, Italy;IIGM, Turin, Italy4 aut
700	1	a Suderman, Matthewu Univ Bristol, Bristol Med Sch, MRC Integrat Epidemiol Unit, Populat Hlth Sci, Bristol, Avon, England4 aut
700	1	a Wilson, Roryu Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Bavaria, Germany;Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Bavaria, Germany4 aut
700	1	a Karhunen, Villeu Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England4 aut
700	1	a Andrew, Tobyu Imperial Coll London, Dept Med, Genom Common Dis, London, England4 aut
700	1	a Wiklund, Petriu Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland;Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England;Univ Jyvaskyla, Dept Hlth Sci, Jyvaskyla, Finland4 aut
700	1	a Wielscher, Matthiasu Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England4 aut
700	1	a Guarrera, Simonettau Univ Turin, Dept Med Sci, Turin, Italy;IIGM, Turin, Italy4 aut
700	1	a Teumer, Alexanderu Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany4 aut
700	1	a Lehne, Benjaminu Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England4 aut
700	1	a Milani, Lili,d 1981-u Uppsala universitet,Molekylär medicin,Univ Tartu, Estonian Genome Ctr, Inst Genom, Tartu, Estonia4 aut0 (Swepub:uu)livoj956
700	1	a de Klein, Nieku Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands4 aut
700	1	a Mishra, Pashupati P.u Fimlab Labs, Dept Clin Chem, Tampere, Finland;Univ Tampere, Fac Med & Life Sci, Dept Clin Chem, Finnish Cardiovasc Res Ctr Tampere, Tampere, Finland4 aut
700	1	a Melton, Phillip E.u Curtin Univ, Sch Pharm & Biomed Sci, Bentley, WA, Australia;Univ Western Australia, Curtin UWA Ctr Genet Origins Hlth & Dis, Sch Biomed Sci, Crawley, Australia4 aut
700	1	a Mandaviya, Pooja R.u Erasmus Univ, Dept Internal Med, Med Ctr, Rotterdam, Netherlands4 aut
700	1	a Kasela, Silvau Univ Tartu, Estonian Genome Ctr, Inst Genom, Tartu, Estonia4 aut
700	1	a Nano, Janau Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Bavaria, Germany;Erasmus Univ, Dept Epidemiol, Med Ctr, Rotterdam, Netherlands4 aut
700	1	a Zhang, Weihuau Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England;North West Healthcare NHS Trust, Dept Cardiol, Ealing Hosp, London, England4 aut
700	1	a Zhang, Yanu German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany4 aut
700	1	a Uitterlinden, Andre G.u Erasmus Univ, Dept Internal Med, Med Ctr, Rotterdam, Netherlands;Erasmus Univ, Dept Epidemiol, Med Ctr, Rotterdam, Netherlands4 aut
700	1	a Peters, Annetteu Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Bavaria, Germany;Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Bavaria, Germany;German Ctr Cardiovasc Res DZHK, Partner Site Munich Heart Alliance, Munich, Germany4 aut
700	1	a Schoettker, Benu German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany;Heidelberg Univ, Network Aging Res, Bergheimer Str, Heidelberg, Germany4 aut
700	1	a Gieger, Christianu Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Bavaria, Germany;Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Bavaria, Germany;German Ctr Cardiovasc Res DZHK, Partner Site Munich Heart Alliance, Munich, Germany4 aut
700	1	a Anderson, Deniseu Univ Western Australia, Telethon Kids Inst, Perth, WA, Australia4 aut
700	1	a Boomsma, Dorret, Iu Vrije Univ Amsterdam, Sch Publ Hlth, Dept Biol Psychol, Amsterdam, Netherlands4 aut
700	1	a Grabe, Hans J.u Univ Med Greifswald, Dept Psychiat & Psychotherapy, Greifswald, Germany;German Ctr Neurodegenerat Dis DZNF, Site Rostock Greifswald, Greifswald, Germany4 aut
700	1	a Panico, Salvatoreu Univ Naples Federico II, Dept Clin Med & Surg, Naples, Italy4 aut
700	1	a Veldink, Jan H.u Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, Utrecht, Netherlands4 aut
700	1	a van Meurs, Joyce B. J.u Erasmus Univ, Dept Internal Med, Med Ctr, Rotterdam, Netherlands4 aut
700	1	a van den Berg, Leonardu Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, Utrecht, Netherlands4 aut
700	1	a Beilin, Lawrence J.u Univ Western Australia, Med Sch, Perth, WA, Australia4 aut
700	1	a Franke, Ludeu Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands4 aut
700	1	a Loh, Marieu Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England;ASTAR, TLGM, 8A Biomed Grove,Level 5, Singapore, Singapore;Univ Oulu, Inst Hlth Sci, Oulu, Finland4 aut
700	1	a van Greevenbroek, Marleen M. J.u Maastricht Univ, Dept Internal Med, Med Ctr, Maastricht, Netherlands;Maastricht Univ, Sch Cardiovasc Dis CARIM, Med Ctr, Maastricht, Netherlands4 aut
700	1	a Nauck, Matthiasu DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany;Univ Med Greifswald, Inst Clin Chem & Lab Med, Greifswald, Germany4 aut
700	1	a Kahonen, Mikau Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland;Univ Tampere, Fac Med & Life Sci, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Physiol, Tampere, Finland4 aut
700	1	a Hurme, Mikko A.u Fac Med & Life Sci Univ Tampere, Dept Microbiol & Immunol, Tampere, Finland4 aut
700	1	a Raitakari, Olli T.u Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku, Finland;Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland4 aut
700	1	a Franco, Oscar H.u Erasmus Univ, Dept Epidemiol, Med Ctr, Rotterdam, Netherlands4 aut
700	1	a Slagboom, P. Elineu Leiden Univ, Dept Biomed Data Sci, Mol Epidemiol, Med Ctr, Leiden, Netherlands4 aut
700	1	a van der Harst, Pimu Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands;Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands;ICIN Netherlands Heart Inst, Durrer Ctr Cardiogenet Res, Utrecht, Netherlands4 aut
700	1	a Kunze, Sonjau Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Bavaria, Germany;Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Bavaria, Germany4 aut
700	1	a Felix, Stephan B.u DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany4 aut
700	1	a Zhang, Taou Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA;Shandong Univ, Sch Publ Hlth, Dept Biostat, Jinan, Shandong, Peoples R China4 aut
700	1	a Chen, Weiu Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA4 aut
700	1	a Mori, Trevor A.u Univ Western Australia, Med Sch, Perth, WA, Australia4 aut
700	1	a Bonnefond, Amelieu Imperial Coll London, Dept Med, Genom Common Dis, London, England;Univ Lille, EGID, Inst Pasteur Lille, CMS UMR 8199, Lille, France4 aut
700	1	a Heijmans, Bastiaan T.u Leiden Univ, Dept Biomed Data Sci, Mol Epidemiol, Med Ctr, Leiden, Netherlands4 aut
700	1	a Muka, Taulantu Erasmus Univ, Dept Epidemiol, Med Ctr, Rotterdam, Netherlands4 aut
700	1	a Kooner, Jaspal S.u Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England;North West Healthcare NHS Trust, Dept Cardiol, Ealing Hosp, London, England;Imperial Coll London, Natl Heart & Lung Inst, London, England;Childrens Minnesota Res Inst, Childrens Hosp & Clin, Minneapolis, MN 55404 USA4 aut
700	1	a Fischer, Kristau Univ Tartu, Estonian Genome Ctr, Inst Genom, Tartu, Estonia4 aut
700	1	a Waldenberger, Melanieu Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Bavaria, Germany;Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Bavaria, Germany;German Ctr Cardiovasc Res DZHK, Partner Site Munich Heart Alliance, Munich, Germany4 aut
700	1	a Froguel, Philippeu Imperial Coll London, Dept Med, Genom Common Dis, London, England;Univ Lille, EGID, Inst Pasteur Lille, CMS UMR 8199, Lille, France4 aut
700	1	a Huang, Rae-Chiu Univ Western Australia, Telethon Kids Inst, Perth, WA, Australia4 aut
700	1	a Lehtimaki, Terhou Fimlab Labs, Dept Clin Chem, Tampere, Finland;Univ Tampere, Fac Med & Life Sci, Dept Clin Chem, Finnish Cardiovasc Res Ctr Tampere, Tampere, Finland4 aut
700	1	a Rathmann, Wolfgangu Heine Univ, Inst Biometr & Epidemiol, Leibniz Ctr Diabet Res Heinrich, German Diabet Ctr, Dusseldorf, Germany4 aut
700	1	a Relton, Caroline L.u Univ Bristol, Bristol Med Sch, MRC Integrat Epidemiol Unit, Populat Hlth Sci, Bristol, Avon, England4 aut
700	1	a Matullo, Giuseppeu Univ Turin, Dept Med Sci, Turin, Italy;IIGM, Turin, Italy4 aut
700	1	a Brenner, Hermannu German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany;Heidelberg Univ, Network Aging Res, Bergheimer Str, Heidelberg, Germany4 aut
700	1	a Verweij, Nieku Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands4 aut
700	1	a Li, Shengxuu Childrens Minnesota Res Inst, Childrens Hosp & Clin, Minneapolis, MN 55404 USA4 aut
700	1	a Chambers, John C.u Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England;North West Healthcare NHS Trust, Dept Cardiol, Ealing Hosp, London, England;Imperial Coll Healthcare NHS Trust, London, England;Nanyang Technol Univ Singapore, Lee Kong Chian Sch Med, Singapore, Singapore4 aut
700	1	a Jarvelin, Marjo-Riittau Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland;Univ Oulu, Bioctr Oulu, Oulu, Finland;Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England;Brunel Univ London, Dept Life Sci, Coll Hlth & Life Sci, Uxbridge, Middx, England4 aut
700	1	a Sebert, Sylvainu Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland;Univ Oulu, Bioctr Oulu, Oulu, Finland;Univ Oulu, Med Res Ctr MRC Oulu, Oulu Univ Hosp, Oulu, Finland4 aut
710	2	a Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland;Univ Oulu, Bioctr Oulu, Oulu, Finlandb Univ Turin, Dept Med Sci, Turin, Italy;IIGM, Turin, Italy4 org
773	0	t EBioMedicined : Elsevier BVg 38, s. 206-216q 38<206-216x 2352-3964
856	4	u https://doi.org/10.1016/j.ebiom.2018.10.066y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1278329/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u http://www.thelancet.com/article/S2352396418304870/pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-373242
856	4 8	u https://doi.org/10.1016/j.ebiom.2018.10.066

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Av författaren/redakt...: Parmar, Priyanka; Lowry, Estelle; Cugliari, Giovan ...; Suderman, Matthe ...; Wilson, Rory; Karhunen, Ville; visa fler...; Andrew, Toby; Wiklund, Petri; Wielscher, Matth ...; Guarrera, Simone ...; Teumer, Alexande ...; Lehne, Benjamin; Milani, Lili, 19 ...; de Klein, Niek; Mishra, Pashupat ...; Melton, Phillip ...; Mandaviya, Pooja ...; Kasela, Silva; Nano, Jana; Zhang, Weihua; Zhang, Yan; Uitterlinden, An ...; Peters, Annette; Schoettker, Ben; Gieger, Christia ...; Anderson, Denise; Boomsma, Dorret, ...; Grabe, Hans J.; Panico, Salvator ...; Veldink, Jan H.; van Meurs, Joyce ...; van den Berg, Le ...; Beilin, Lawrence ...; Franke, Lude; Loh, Marie; van Greevenbroek ...; Nauck, Matthias; Kahonen, Mika; Hurme, Mikko A.; Raitakari, Olli ...; Franco, Oscar H.; Slagboom, P. Eli ...; van der Harst, P ...; Kunze, Sonja; Felix, Stephan B ...; Zhang, Tao; Chen, Wei; Mori, Trevor A.; Bonnefond, Ameli ...; Heijmans, Bastia ...; Muka, Taulant; Kooner, Jaspal S ...; Fischer, Krista; Waldenberger, Me ...; Froguel, Philipp ...; Huang, Rae-Chi; Lehtimaki, Terho; Rathmann, Wolfga ...; Relton, Caroline ...; Matullo, Giusepp ...; Brenner, Hermann; Verweij, Niek; Li, Shengxu; Chambers, John C ...; Jarvelin, Marjo- ...; Sebert, Sylvain; visa färre...

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