Peroxisome Proliferator Activated Receptor Gamma Controls Mature Brown Adipocyte Inducibility through Glycerol Kinase

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Peroxisome Proliferator Activated Receptor Gamma Controls Mature Brown Adipocyte Inducibility through Glycerol Kinase

Lasar, D. (author)

Rosenwald, M. (author)

Kiehlmann, E. (author)

Balaz, M. (author)

Tall, B. (author)

Opitz, L. (author)

Lidell, Martin, 1970 (author): Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine

Zamboni, N. (author)

Krznar, P. (author)

Sun, W. F. (author)

Varga, L. (author)

Stefanicka, P. (author)

Ukropec, J. (author)

Nuutila, P. (author)

Virtanen, K. (author)

Amri, E. Z. (author)

Enerbäck, Sven, 1958 (author): Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine

Wahli, W. (author)

Wolfrum, C. (author)

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(creator_code:org_t)

Elsevier BV, 2018
2018
English.
In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 22:3, s. 760-773

Related links:: http://www.cell.com/...; show more...; https://gup.ub.gu.se...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Peroxisome proliferator-activated receptors (PPARs) have been suggested as the master regulators of adipose tissue formation. However, their role in regulating brown fat functionality has not been resolved. To address this question, we generated mice with inducible brown fat-specific deletions of PPAR alpha, beta/delta, and gamma, respectively. We found that both PPARa and beta/delta are dispensable for brown fat function. In contrast, we could show that ablation of PPAR gamma in vitro and in vivo led to a reduced thermogenic capacity accompanied by a loss of inducibility by beta-adrenergic signaling, as well as a shift from oxidative fatty acid metabolism to glucose utilization. We identified glycerol kinase (Gyk) as a partial mediator of PPAR gamma function and could show that Gyk expression correlates with brown fat thermogenic capacity in human brown fat biopsies. Thus, Gyk might constitute the link between PPAR gamma-mediated regulation of brown fat function and activation by b-adrenergic signaling.

Subject headings

NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)

Keyword

uncoupling protein-1 gene
ppar-gamma
adipose-tissue
insulin-resistance
white adipocytes
energy-metabolism
fat
expression
obesity
alpha
Cell Biology
akrabarty k
1983
journal of lipid research
v24
p381

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art (subject category)

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By the author/editor: Lasar, D.; Rosenwald, M.; Kiehlmann, E.; Balaz, M.; Tall, B.; Opitz, L.; show more...; Lidell, Martin, ...; Zamboni, N.; Krznar, P.; Sun, W. F.; Varga, L.; Stefanicka, P.; Ukropec, J.; Nuutila, P.; Virtanen, K.; Amri, E. Z.; Enerbäck, Sven, ...; Wahli, W.; Wolfrum, C.; show less...

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NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Genetics

Articles in the publication: Cell Reports

By the university: University of Gothenburg

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