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  • Varga, A. W. (author)

Reduced Slow-Wave Sleep Is Associated with High Cerebrospinal Fluid A beta 42 Levels in Cognitively Normal Elderly

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-11-01
  • Oxford University Press (OUP),2016

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/247998
  • https://gup.ub.gu.se/publication/247998URI
  • https://doi.org/10.5665/sleep.6240DOI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Study Objectives: Emerging evidence suggests a role for sleep in contributing to the progression of Alzheimer disease (AD). Slow wave sleep (SWS) is the stage during which synaptic activity is minimal and clearance of neuronal metabolites is high, making it an ideal state to regulate levels of amyloid beta (A beta). We thus aimed to examine relationships between concentrations of A beta 42 in the cerebrospinal fluid (CSF) and measures of SWS in cognitively normal elderly subjects. Methods: Thirty-six subjects underwent a clinical and cognitive assessment, a structural MRI, a morning to early afternoon lumbar puncture, and nocturnal polysomnography. Correlations and linear regression analyses were used to assess for associations between CSF A beta 42 levels and measures of SWS controlling for potential confounders. Resulting models were compared to each other using ordinary least squared linear regression analysis. Additionally, the participant sample was dichotomized into "high" and "low" A beta 42 groups to compare SWS bout length using survival analyses. Results: A significant inverse correlation was found between CSF A beta 42 levels, SWS duration and other SWS characteristics. Collectively, total SWA in the frontal lead was the best predictor of reduced CSF A beta 42 levels when controlling for age and ApoE status. Total sleep time, time spent in NREM1, NREM2, or REM sleep were not correlated with CSF A beta 42. Conclusions: In cognitively normal elderly, reduced and fragmented SWS is associated with increases in CSF A beta 42, suggesting that disturbed sleep might drive an increase in soluble brain A beta levels prior to amyloid deposition.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Wohlleber, M. E. (author)
  • Gimenez, S. (author)
  • Romero, S. (author)
  • Alonso, J. F. (author)
  • Ducca, E. L. (author)
  • Kam, K. (author)
  • Lewis, C. (author)
  • Tanzi, E. B. (author)
  • Tweardy, S. (author)
  • Kishi, A. (author)
  • Parekh, A. (author)
  • Fischer, E. (author)
  • Gumb, T. (author)
  • Alcolea, D. (author)
  • Fortea, J. (author)
  • Lleo, A. (author)
  • Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
  • Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
  • Mosconi, L. (author)
  • Glodzik, L. (author)
  • Pirraglia, E. (author)
  • Burschtin, O. E. (author)
  • de Leon, M. J. (author)
  • Rapoport, D. M. (author)
  • Lu, S. E. (author)
  • Ayappa, I. (author)
  • Osorio, R. S. (author)
  • Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

Related titles

  • In:Sleep: Oxford University Press (OUP)39:11, s. 2041-20480161-81051550-9109

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