Expression profile, molecular functions, and prognostic significance of miRNAs in primary colorectal cancer stem cells

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Fan, Chuan-Wen (author): Institute of Digestive Surgery, Sichuan University, and Department of Gastrointestinal Surgery, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China; Department of Gastrointestinal Surgery and Breast and Thyroid Surgery, Minimally Invasive Surgery, West China Fourth Hospital, Sichuan University, Chengdu, China; Department of Oncology and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden; Laboratory of Stem Cell Biology, West China Hospital, Sichuan University, Chengdu, China

Lu, Ran (author): Laboratory of Stem Cell Biology, West China Hospital, Sichuan University, Chengdu, China,Sichuan Univ, Peoples R China

Fang, Chao (author): Institute of Digestive Surgery, Sichuan University, and Department of Gastrointestinal Surgery, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China,Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China

Zhang, Xue-Li (author): School of Medicine, Institute of Medical Sciences, Örebro University, Örebro, Sweden,Orebro Univ, Sweden

Lv, Zhao-Ying (author): Institute of Digestive Surgery, Sichuan University, and Department of Gastrointestinal Surgery, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China,Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China

Li, Yuan (author): Institute of Digestive Surgery, Sichuan University, and Department of Gastrointestinal Surgery, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China,Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China

Zhang, Hong, 1957- (author): Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden,Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China

Zhou, Zong-Guang (author): Institute of Digestive Surgery, Sichuan University, and Department of Gastrointestinal Surgery, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China

Mo, Xian-Ming (author): Laboratory of Stem Cell Biology, West China Hospital, Sichuan University, Chengdu, China,Sichuan Univ, Peoples R China

Sun, Xiao-Feng (author): Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US

Fan, Chuanwen (author): Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China

(creator_code:org_t)

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Abstract Subject headings

MicroRNAs (miRNAs) are known to drive the pathogenesis of colorectal cancer (CRC) via the regulation of cancer stem cells (CSCs). We studied the miRNA expression profile of primary CSCs isolated from patients with CRC (pCRCSCs). Compared to pCRCSC-derived differentiated cells, 98 differentially expressed miRNAs were identified in pCRCSCs. Target genes encoding pCRCSC-related miRNAs were identified using a combination of miRNA target databases and miRNA-mRNA regulatory networks from the same patient. The pCRCSC-related miRNA target genes were associated with pathways contributing to malignant phenotypes, including I-kappa B kinase/NF-kappa B signaling, signal transduction by p53 class mediator, Ras signaling, and cGMP-PKG signaling. The pCRCSC-related miRNA expression signature was independently associated with poor overall survival in both the training and validation cohorts. We have thus identified several pCRCSC-related miRNAs with oncogenic potential that could serve as prognostic biomarkers for CRC.

By the author/editor: Fan, Chuan-Wen; Lu, Ran; Fang, Chao; Zhang, Xue-Li; Lv, Zhao-Ying; Li, Yuan; show more...; Zhang, Hong, 195 ...; Zhou, Zong-Guang; Mo, Xian-Ming; Sun, Xiao-Feng; Fan, Chuanwen; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Geriatrics

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