WFRF:(Zheng S. Lilly)
Sökning: WFRF:(Zheng S. Lilly) > (2005-2009) > Inherited variation...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04216naa a2200433 4500 | |
| 001 | oai:DiVA.org:mdh-40710 | |
| 003 | SwePub | |
| 008 | 180906s2007 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:umu-2505 | |
| 009 | oai:prod.swepub.kib.ki.se:115870696 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-407102 URI |
| 024 | 7 | a https://doi.org/10.1158/1078-0432.CCR-07-06692 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-25052 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1158706962 URI |
| 040 | a (SwePub)mdhd (SwePub)umud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Lindstrom, Sarau Umeå universitet,Onkologi4 aut |
| 245 | 1 0 | a Inherited variation in hormone-regulating genes and prostate cancer survival |
| 264 | 1 | a Umea Univ, Dept Radiat Sci Oncol, SE-90185 Umea, Sweden. Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden. Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. Wake Forest Univ, Sch Med, Ctr Human Genom, Winston Salem, NC 27109 USA.b AMER ASSOC CANCER RESEARCH,c 2007 |
| 338 | a print2 rdacarrier | |
| 520 | a Purpose: Hormonal manipulation is the mainstay treatment of prostate cancer, notably in advanced stages. Despite initial favorably response, the cancer eventually develops hormone resistance resulting in disease progression and death. However, little is known about genetic determinants of disease progression and prostate cancer-specific death. Experimental Design: We analyzed a population-based cohort comprising 2,761 men diagnosed with prostate cancer from March 2001 to October 2003 and with complete follow-up through July 2006. During a median follow-up time of 3.8 years, a total of 300 men had died from prostate cancer. We genotyped 23 haplotype tagging single nucleoticle polymorphisms in the genes AR, CYP17, and SRD5A2 and used Cox proportional hazards analyses to quantify associations between genotype and risk of dying from prostate cancer. Results: The variant 'A': allele of an AR promoter single nucleoticle polymorphism, rs17302090, was borderline associated with a 50% increased risk of dying from prostate cancer (95% confidence interval, 1.0-2.3; P = 0.07). This finding was more pronounced in patients who received hormonal therapy as primary treatment at diagnosis (hazard ratio, 19; 95% confidence interval, 1.3-2.9; P = 0.007). We did not identify any associations between CYP17 or SRD5A2 variation and prostate cancer-specific death. Conclusions: Our results suggest that inherited genetic variation in the androgen receptor gene affects hormonal treatment response and ultimately prostate cancer death. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskap0 (SwePub)3032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciences0 (SwePub)3032 hsv//eng |
| 700 | 1 | a Adami, Hans-Olovu Karolinska Institutet4 aut |
| 700 | 1 | a Bälter, Katarina Augustssonu Karolinska Institutet4 aut0 (Swepub:mdh)kbr01 |
| 700 | 1 | a Xu, Jianfeng4 aut |
| 700 | 1 | a Zheng, S. Lilly4 aut |
| 700 | 1 | a Stattin, Paeru Umeå universitet,Urologi och andrologi4 aut |
| 700 | 1 | a Gronberg, Henriku Karolinska Institutet4 aut |
| 700 | 1 | a Wiklund, Fredriku Karolinska Institutet4 aut |
| 710 | 2 | a Umeå universitetb Onkologi4 org |
| 773 | 0 | t Clinical Cancer Researchd Umea Univ, Dept Radiat Sci Oncol, SE-90185 Umea, Sweden. Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden. Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. Wake Forest Univ, Sch Med, Ctr Human Genom, Winston Salem, NC 27109 USA. : AMER ASSOC CANCER RESEARCHg 13:17, s. 5156-5161q 13:17<5156-5161x 1078-0432x 1557-3265 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-40710 |
| 856 | 4 8 | u https://doi.org/10.1158/1078-0432.CCR-07-0669 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2505 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:115870696 |
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