Sökning: WFRF:(de Vries Linda S) > Assessment of Brain...
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000 | 05825naa a2200721 4500 | |
001 | oai:lup.lub.lu.se:9b88ec94-2d70-4cb9-be62-3af044767dd1 | |
003 | SwePub | |
008 | 231019s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/9b88ec94-2d70-4cb9-be62-3af044767dd12 URI |
024 | 7 | a https://doi.org/10.1016/j.jpeds.2018.12.0622 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Cizmeci, Mehmet Nu University Medical Center Utrecht4 aut |
245 | 1 0 | a Assessment of Brain Injury and Brain Volumes after Posthemorrhagic Ventricular Dilatation : A Nested Substudy of the Randomized Controlled ELVIS Trial |
264 | 1 | b Elsevier BV,c 2019 |
520 | a OBJECTIVE: To compare the effect of early and late intervention for posthemorrhagic ventricular dilatation on additional brain injury and ventricular volume using term-equivalent age-MRI.STUDY DESIGN: In the Early vs Late Ventricular Intervention Study (ELVIS) trial, 126 preterm infants ≤34 weeks of gestation with posthemorrhagic ventricular dilatation were randomized to low-threshold (ventricular index >p97 and anterior horn width >6 mm) or high-threshold (ventricular index >p97 + 4 mm and anterior horn width >10 mm) groups. In 88 of those (80%) with a term-equivalent age-MRI, the Kidokoro Global Brain Abnormality Score and the frontal and occipital horn ratio were measured. Automatic segmentation was used for volumetric analysis.RESULTS: The total Kidokoro score of the infants in the low-threshold group (n = 44) was lower than in the high-threshold group (n = 44; median, 8 [IQR, 5-12] vs median 12 [IQR, 9-17], respectively; P < .001). More infants in the low-threshold group had a normal or mildly increased score vs more infants in the high-threshold group with a moderately or severely increased score (46% vs 11% and 89% vs 54%, respectively; P = .002). The frontal and occipital horn ratio was lower in the low-threshold group (median, 0.42 [IQR, 0.34-0.63]) than the high-threshold group (median 0.48 [IQR, 0.37-0.68], respectively; P = .001). Ventricular cerebrospinal fluid volumes could be calculated in 47 infants and were smaller in the low-threshold group (P = .03).CONCLUSIONS: More brain injury and larger ventricular volumes were demonstrated in the high vs the low-threshold group. These results support the positive effects of early intervention for posthemorrhagic ventricular dilatation.TRIAL REGISTRATION: ISRCTN43171322. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
653 | a Brain/diagnostic imaging | |
653 | a Brain Injuries/diagnostic imaging | |
653 | a Cerebral Hemorrhage/diagnostic imaging | |
653 | a Cerebral Ventricles/diagnostic imaging | |
653 | a Cerebrospinal Fluid | |
653 | a Cerebrospinal Fluid Shunts | |
653 | a Dilatation | |
653 | a Female | |
653 | a Humans | |
653 | a Hydrocephalus/diagnostic imaging | |
653 | a Infant, Newborn | |
653 | a Infant, Premature | |
653 | a Infant, Premature, Diseases/diagnostic imaging | |
653 | a Intracranial Hemorrhages/diagnostic imaging | |
653 | a Magnetic Resonance Imaging | |
653 | a Male | |
653 | a White Matter/diagnostic imaging | |
700 | 1 | a Khalili, Nadiehu University Medical Center Utrecht4 aut |
700 | 1 | a Claessens, Nathalie H Pu University Medical Center Utrecht4 aut |
700 | 1 | a Groenendaal, Florisu University Medical Center Utrecht4 aut |
700 | 1 | a Liem, Kian Du Radboud University Medical Center4 aut |
700 | 1 | a Heep, Axelu University of Bristol4 aut |
700 | 1 | a Benavente-Fernández, Isabelu Puerta del Mar University Hospital4 aut |
700 | 1 | a van Straaten, Henrica L Mu Isala Women and Children's Hospital4 aut |
700 | 1 | a van Wezel-Meijler, Gerdau Leiden University Medical Centre4 aut |
700 | 1 | a Steggerda, Sylke Ju Leiden University Medical Centre4 aut |
700 | 1 | a Dudink, Jeroenu University Medical Center Utrecht4 aut |
700 | 1 | a Išgum, Ivanau University Medical Center Utrecht4 aut |
700 | 1 | a Whitelaw, Andrewu University of Bristol4 aut |
700 | 1 | a Benders, Manon J N Lu University Medical Center Utrecht4 aut |
700 | 1 | a de Vries, Linda Su University Medical Center Utrecht4 aut |
700 | 1 | a Ley, Davidu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neonatalogi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neonatology,Lund University Research Groups4 cre0 (Swepub:lu)pedi-dle |
700 | 1 | a Fellman, Vinetau Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 cre0 (Swepub:lu)pedi-vfe |
710 | 2 | a University Medical Center Utrechtb Radboud University Medical Center4 org |
710 | 2 | a ELVIS study group |
773 | 0 | t Journal of Pediatricsd : Elsevier BVg 208, s. 2-197q 208<2-197x 1097-6833x 0022-3476 |
856 | 4 | u http://dx.doi.org/10.1016/j.jpeds.2018.12.062y FULLTEXT |
856 | 4 | u https://research-information.bris.ac.uk/ws/files/205028352/Manuscript_R10_1_.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/9b88ec94-2d70-4cb9-be62-3af044767dd1 |
856 | 4 8 | u https://doi.org/10.1016/j.jpeds.2018.12.062 |
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