Brief Report : IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies

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Fältnamn	Indikatorer	Metadata
000		12499naa a2201417 4500
001		oai:lup.lub.lu.se:d5fa7c4f-87c1-4abe-b5d1-84993d4eaac8
003		SwePub
008		160921s2016 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:134219295
024	7	a https://lup.lub.lu.se/record/d5fa7c4f-87c1-4abe-b5d1-84993d4eaac82 URI
024	7	a https://doi.org/10.1002/art.397302 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1342192952 URI
040		a (SwePub)lud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a López-Isac, Elenau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
245	1 0	a Brief Report : IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies
264		c 2016-08-25
264	1	b Wiley,c 2016
300		a 7 s.
520		a Objective: Systemic sclerosis (SSc) and rheumatoid arthritis (RA) are autoimmune diseases that have similar clinical and immunologic characteristics. To date, several shared SSc–RA genetic loci have been identified independently. The aim of the current study was to systematically search for new common SSc–RA loci through an interdisease meta–genome-wide association (meta-GWAS) strategy. Methods: The study was designed as a meta-analysis combining GWAS data sets of patients with SSc and patients with RA, using a strategy that allowed identification of loci with both same-direction and opposite-direction allelic effects. The top single-nucleotide polymorphisms were followed up in independent SSc and RA case–control cohorts. This allowed an increase in the sample size to a total of 8,830 patients with SSc, 16,870 patients with RA, and 43,393 healthy controls. Results: This cross-disease meta-analysis of the GWAS data sets identified several loci with nominal association signals (P < 5 × 10−6) that also showed evidence of association in the disease-specific GWAS scans. These loci included several genomic regions not previously reported as shared loci, as well as several risk factors that were previously found to be associated with both diseases. Follow-up analyses of the putatively new SSc–RA loci identified IRF4 as a shared risk factor for these 2 diseases (Pcombined = 3.29 × 10−12). Analysis of the biologic relevance of the known SSc–RA shared loci identified the type I interferon and interleukin-12 signaling pathways as the main common etiologic factors. Conclusion: This study identified a novel shared locus, IRF4, for the risk of SSc and RA, and highlighted the usefulness of a cross-disease GWAS meta-analysis strategy in the identification of common risk loci.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
653		a GWAS
653		a Rheumatoid Arthritis
653		a IRF4
653		a SYSTEMIC SCLEROSIS
700	1	a Martín, Jose Ezequielu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Assassi, Shervinu University of Texas4 aut
700	1	a Simeón, Carmen P.u Vall d'Hebron University Hospital4 aut
700	1	a Carreira, Patriciau 12 de Octubre University Hospital,University Medical Center Utrecht4 aut
700	1	a Ortego-Centeno, Norbertou Hospital Clínico Universitario San Cecilio4 aut
700	1	a Freire, Maykau University of Vigo,CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Beltrán, Emmau Valencia University Hospital,CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Narváez, Javieru Bellvitge University Hospital-IDIBELL,CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Alegre-Sancho, Juan J.u Hospital Universitario Doctor Peset,CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Fernández-Gutiérrez, Benjamínu Hospital Clinico San Carlos de Madrid4 aut
700	1	a Balsa, Alejandrou University Hospital La Paz4 aut
700	1	a Ortiz, Ana M.u Hospital Universitario de la Princesa4 aut
700	1	a González-Gay, Miguel A.u University of Cantabria4 aut
700	1	a Beretta, Lorenzou Maggiore Hospital Policlinico4 aut
700	1	a Santaniello, Alessandrou Maggiore Hospital Policlinico4 aut
700	1	a Bellocchi, Chiarau Maggiore Hospital Policlinico4 aut
700	1	a Lunardi, Claudiou University of Verona4 aut
700	1	a Moroncini, Gianlucau Marche Polytechnic University4 aut
700	1	a Gabrielli, Armandou Marche Polytechnic University4 aut
700	1	a Witte, Torstenu Hannover Medical School4 aut
700	1	a Hunzelmann, Nicolasu University of Cologne4 aut
700	1	a Distler, Jörg H Wu Friedrich-Alexander University Erlangen-Nürnberg4 aut
700	1	a Riekemasten, Gabriellau British Columbia Children's Hospital4 aut
700	1	a van der Helm-van Mil, Annette H.u Leiden University Medical Centre4 aut
700	1	a de Vries-Bouwstra, Jeskau Leiden University Medical Centre4 aut
700	1	a Magro-Checa, Cesaru Leiden University Medical Centre4 aut
700	1	a Voskuyl, Alexandre E.u Amsterdam UMC - Vrije Universiteit Amsterdam4 aut
700	1	a Vonk, Madelon C.u Radboud University Nijmegen4 aut
700	1	a Molberg, Øyvindu University of Oslo4 aut
700	1	a Merriman, Tonyu University of Otago4 aut
700	1	a Hesselstrand, Rogeru Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt-lungsjukdom - information, stöd och bemötande,Forskargrupper vid Lunds universitet,Forskargruppen för systemisk skleros, Lund,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Cardiopulmonary disease - information, support and reception,Lund University Research Groups,Lund Systemic Sclerosis Research Group4 aut0 (Swepub:lu)reum-rhe
700	1	a Nordin, Annikau Karolinska Institutet,Karolinska University Hospital4 aut
700	1	a Padyukov, Leonidu Karolinska Institutet,Karolinska University Hospital4 aut
700	1	a Herrick, Arianeu University of Manchester4 aut
700	1	a Eyre, Steveu University of Manchester4 aut
700	1	a Koeleman, Bobby P Cu University Medical Center Utrecht4 aut
700	1	a Denton, Christopher P.u University College London4 aut
700	1	a Fonseca, Carmenu University College London4 aut
700	1	a Radstake, Timothy R D Ju University Medical Center Utrecht,CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Worthington, Janeu University of Manchester4 aut
700	1	a Mayes, Maureen D.u University of Texas4 aut
700	1	a Martín, Javieru CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Ríos, Raquelu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Callejas, Jose Luisu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Hitos, José Antonio Vargasu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Portales, Rosa Garcíau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Camps, María Teresau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Fernández-Nebro, Antoniou CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a González-Escribano, María F.u CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a García-Hernández, Francisco Joséu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Castillo, Ma Jesúsu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Ángeles Aguirre, Mau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Gómez-Gracia, Inmaculadau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Rodríguez-Rodríguez, Luisu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Peña, Paloma García de lau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Vicente, Estheru CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Andreu, José Luisu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a de Castro, Mónica Fernándezu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a López-Longo, Francisco Javieru CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Martínez, Linau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Fonollosa, Vicenteu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Guillén, Alfredou CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Castellví, Ivánu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Espinosa, Gerardu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Tolosa, Carlosu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Pros, Annau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Carballeira, Mónica Rodríguezu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Narváez, Francisco Javieru CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Rivas, Manel Rubiou CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Ortiz-Santamaría, Verau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Madroñero, Ana Belénu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Díaz, Bernardinou CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Trapiella, Luisu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Sousa, Adriánu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Egurbide, María Victoriau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Mateo, Patricia Fanlou CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Sáez-Comet, Luisu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Díaz, Federicou CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Hernández, Vanesau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Beltrán, Emmau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Román-Ivorra, José Andrésu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Grau, Elenau CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Alegre-Sancho, Juan Joséu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Blanco García, Francisco J.u CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
700	1	a Oreiro, Natividadu CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)4 aut
710	2	a CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)b University of Texas4 org
773	0	t Arthritis & Rheumatologyd : Wileyg 68:9, s. 2338-2344q 68:9<2338-2344x 2326-5191x 2326-5205
856	4	u http://dx.doi.org/10.1002/art.39730y FULLTEXT
856	4	u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/art.39730
856	4 8	u https://lup.lub.lu.se/record/d5fa7c4f-87c1-4abe-b5d1-84993d4eaac8
856	4 8	u https://doi.org/10.1002/art.39730
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:134219295

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