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Sökning: WFRF:(van der Lely A. J.) > Fractures, Bone Min...

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FältnamnIndikatorerMetadata
00004347naa a2200589 4500
001oai:gup.ub.gu.se/293541
003SwePub
008240528s2020 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/2935412 URI
0247 a https://doi.org/10.1210/clinem/dgz2792 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a van Santen, S. S.4 aut
2451 0a Fractures, Bone Mineral Density, and Final Height in Craniopharyngioma Patients with a Follow-up of 16 Years
264 c 2020-03-07
264 1b The Endocrine Society,c 2020
520 a Context: Pituitary hormonal deficiencies in patients with craniopharyngioma may impair their bone health. Objective: To investigate bone health in patients with craniopharyngioma. Design: Retrospective cross-sectional study. Setting: Dutch and Swedish referral centers. Patients: Patients with craniopharyngioma (n = 177) with available data on bone health after a median follow-up of 16 years (range, 1-62) were included (106 [60%] Dutch, 93 [53%] male, 84 [48%] childhood-onset disease). Main outcome measures: Fractures, dual X-ray absorptiometry-derived bone mineral density (BMD), and final height were evaluated. Low BMD was defined as T- or Z-score <=-1 and very low BMD as <=-2.5 or <=-2.0, respectively. Results: Fractures occurred in 31 patients (18%) and were more frequent in men than in women (26% vs. 8%, P = .002). Mean BMD was normal (Z-score total body 0.1 [range, -4.1 to 3.5]) but T- or Z-score <=-1 occurred in 47 (50%) patients and T-score <=-2.5 or Z-score <=-2.0 in 22 (24%) patients. Men received less often treatment for low BMD than women (7% vs. 18%, P = .02). Female sex (OR 0.3, P = .004) and surgery (odds ratio [OR], 0.2; P = .01) were both independent protective factors for fractures, whereas antiepileptic medication was a risk factor (OR, 3.6; P = .03), whereas T-score <=-2.5 or Z-score <=-2.0 was not (OR, 2.1; P = .21). Mean final height was normal and did not differ between men and women, or adulthood and childhood-onset patients. Conclusions: Men with craniopharyngioma are at higher risk than women for fractures. In patients with craniopharyngioma, a very low BMD (T-score <=-2.5 or Z-score <=-2.0) seems not to be a good predictor for fracture risk.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a craniopharyngioma
653 a bone health
653 a fractures
653 a bone mineral density
653 a final
653 a height
653 a growth-hormone deficiency
653 a childhood-onset craniopharyngioma
653 a replacement therapy
653 a endocrine sequelae
653 a body-composition
653 a children
653 a osteoporosis
653 a risk
653 a weight
653 a women
653 a Endocrinology & Metabolism
7001 a Olsson, Daniel S,d 1983u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xolssd
7001 a van den Heuvel-Eibrink, M. M.4 aut
7001 a Wijnen, M.4 aut
7001 a Hammarstrand, Casper,d 1990u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xhammc
7001 a Janssen, Jamjl4 aut
7001 a Johansson, G.4 aut
7001 a van der Lely, A. J.4 aut
7001 a Neggers, Sjcmm4 aut
7102 a Göteborgs universitetb Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition4 org
7730 t Journal of Clinical Endocrinology & Metabolismd : The Endocrine Societyg 105:4q 105:4x 0021-972Xx 1945-7197
8564 u https://academic.oup.com/jcem/article-pdf/105/4/e1397/33636544/dgz279.pdf
8564 8u https://gup.ub.gu.se/publication/293541
8564 8u https://doi.org/10.1210/clinem/dgz279

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