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Fruit and vegetable...
Fruit and vegetable consumption in relation to hepatocellular carcinoma in a multi-centre, European cohort study
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Bamia, C. (author)
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Lagiou, P. (author)
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Jenab, M. (author)
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show more...
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Aleksandrova, K. (author)
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Fedirko, V. (author)
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Trichopoulos, D. (author)
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Overvad, K. (author)
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Tjonneland, A. (author)
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Olsen, A. (author)
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Clavel-Chapelon, F. (author)
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Boutron-Ruault, M-C (author)
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Kvaskoff, M. (author)
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Katzke, V. A. (author)
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Kuehn, T. (author)
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Boeing, H. (author)
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Noethlings, U. (author)
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Palli, D. (author)
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Sieri, S. (author)
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Panico, S. (author)
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Tumino, R. (author)
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Naccarati, A. (author)
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Bueno-de-Mesquita, H. B(As) (author)
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Peeters, P. H. M. (author)
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- Weiderpass, E. (author)
- Karolinska Institutet
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Skeie, G. (author)
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Quiros, J. R. (author)
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Agudo, A. (author)
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Chirlaque, M-D (author)
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Sanchez, M-J (author)
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Ardanaz, E. (author)
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Dorronsoro, M. (author)
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- Ericson, Ulrika (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Nilsson, Lena Maria (author)
- Umeå universitet,Näringsforskning,Arktiskt centrum vid Umeå universitet (Arcum)
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- Wennberg, Maria (author)
- Umeå universitet,Näringsforskning
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Khaw, K-T (author)
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Wareham, N. (author)
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Key, T. J. (author)
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Travis, R. C. (author)
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Ferrari, P. (author)
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Stepien, M. (author)
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Duarte-Salles, T. (author)
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Norat, T. (author)
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Murphy, N. (author)
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Riboli, E. (author)
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Trichopoulou, A. (author)
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(creator_code:org_t)
- 2015-03-05
- 2015
- English.
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In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 112:7, s. 1273-1282
- Related links:
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https://www.nature.c...
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Subject headings
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- Background:Vegetable and/or fruit intakes in association with hepatocellular carcinoma (HCC) risk have been investigated in case-control studies conducted in specific European countries and cohort studies conducted in Asia, with inconclusive results. No multi-centre European cohort has investigated the indicated associations. Methods: In 486 799 men/women from the European Prospective Investigation into Cancer and nutrition, we identified 201 HCC cases after 11 years median follow-up. We calculated adjusted hazard ratios (HRs) for HCC incidence for sex-specific quintiles and per 100 g d(-1) increments of vegetable/fruit intakes. Results: Higher vegetable intake was associated with a statistically significant, monotonic reduction of HCC risk: HR (100 g d(-1) increment): 0.83; 95% CI: 0.71-0.98. This association was consistent in sensitivity analyses with no apparent heterogeneity across strata of HCC risk factors. Fruit intake was not associated with HCC incidence: HR (100 g d(-1) increment): 1.01; 95% CI: 0.92-1.11. Conclusions: Vegetable, but not fruit, intake is associated with lower HCC risk with no evidence for heterogeneity of this association in strata of important HCC risk factors. Mechanistic studies should clarify pathways underlying this association. Given that HCC prognosis is poor and that vegetables are practically universally accessible, our results may be important, especially for those at high risk for the disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- hepatocellular carcinoma
- liver cancer
- vegetable
- fruit
- EPIC
- cohort
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Bamia, C.
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Lagiou, P.
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Jenab, M.
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Aleksandrova, K.
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Fedirko, V.
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Trichopoulos, D.
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show more...
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Overvad, K.
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Tjonneland, A.
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Olsen, A.
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Clavel-Chapelon, ...
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Boutron-Ruault, ...
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Kvaskoff, M.
-
Katzke, V. A.
-
Kuehn, T.
-
Boeing, H.
-
Noethlings, U.
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Palli, D.
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Sieri, S.
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Panico, S.
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Tumino, R.
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Naccarati, A.
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Bueno-de-Mesquit ...
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Peeters, P. H. M ...
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Weiderpass, E.
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Skeie, G.
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Quiros, J. R.
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Agudo, A.
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Chirlaque, M-D
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Sanchez, M-J
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Ardanaz, E.
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Dorronsoro, M.
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Ericson, Ulrika
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Nilsson, Lena Ma ...
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Wennberg, Maria
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Khaw, K-T
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Wareham, N.
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Key, T. J.
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Travis, R. C.
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Ferrari, P.
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Stepien, M.
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Duarte-Salles, T ...
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Norat, T.
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Murphy, N.
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Riboli, E.
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Trichopoulou, A.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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British Journal ...
- By the university
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Umeå University
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Lund University
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Karolinska Institutet