Prognostic impact of abdominal lymph node involvement in diffuse large B-cell lymphoma

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Fältnamn	Indikatorer	Metadata
000		03874naa a2200481 4500
001		oai:DiVA.org:uu-400949
003		SwePub
008		200103s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4009492 URI
024	7	a https://doi.org/10.1111/ejh.133612 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Abdulla, Maysaau Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini4 aut0 (Swepub:uu)mayab806
245	1 0	a Prognostic impact of abdominal lymph node involvement in diffuse large B-cell lymphoma
264		c 2019-12-20
264	1	b Wiley,c 2020
338		a electronic2 rdacarrier
520		a OBJECTIVE: The prognostic value of site of nodal involvement in diffuse large B-cell lymphomas (DLBCL) is mainly unknown. We aimed to determine the prognostic significance of nodal abdominal involvement in relation to tumour cell markers and clinical characteristics of 249 DLBCL patients in a retrospective single-centre study.METHODS: Contrast-enhanced computed tomography (CT) of the abdomen and thorax revealed pathologically enlarged abdominal lymph nodes in 156 patients, while in 93 patients there were no pathologically enlarged lymph nodes in the abdomen. In 81 cases, the diagnosis of DLBCL was verified by histopathological biopsy obtained from abdominal lymph node.RESULTS: Patients with abdominal nodal disease had inferior lymphoma-specific survival (P = .04) and presented with higher age-adjusted IPI (P < .001), lactate dehydrogenase (P < .001) and more often advanced stage (P < .001), bulky disease (P < .001), B symptoms (P < .001), and double expression of MYC and BCL2 (P = .02) compared to patients without nodal abdominal involvement, but less often extranodal involvement (P < .02). The worst outcome was observed in those where the abdominal nodal involvement was verified by histopathological biopsy.CONCLUSION: Diffuse large B-cell lymphomas patients with abdominal nodal disease had inferior outcome and more aggressive behaviour, reflected both in clinical and biological characteristics.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng
653		a BCL2
653		a DLBCL
653		a MYC
653		a abdominal lymph node
653		a survival
653		a Patologi
653		a Pathology
700	1	a Guglielmo, Priscillau Uppsala universitet,Radiologi,Brotzu General Hospital, Cagliari, Italy4 aut
700	1	a Hollander, Peteru Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini4 aut0 (Swepub:uu)petho189
700	1	a Åström, Gunnar,d 1955-u Uppsala universitet,Radiologi4 aut0 (Swepub:uu)gunnaras
700	1	a Ahlström, Håkan,d 1953-u Uppsala universitet,Radiologi4 aut0 (Swepub:uu)hakanahl
700	1	a Enblad, Gunillau Uppsala universitet,Experimentell och klinisk onkologi4 aut0 (Swepub:uu)gunienbl
700	1	a Amini, Rose-Marieu Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini4 aut0 (Swepub:uu)roseamin
710	2	a Uppsala universitetb Klinisk och experimentell patologi4 org
773	0	t European Journal of Haematologyd : Wileyg 104:3, s. 207-213q 104:3<207-213x 0902-4441x 1600-0609
856	4	u https://doi.org/10.1111/ejh.13361y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1382649/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ejh.13361
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-400949
856	4 8	u https://doi.org/10.1111/ejh.13361

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By the author/editor: Abdulla, Maysaa; Guglielmo, Prisc ...; Hollander, Peter; Åström, Gunnar, ...; Ahlström, Håkan, ...; Enblad, Gunilla; show more...; Amini, Rose-Mari ...; show less...

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