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Circulating Biomark...
Circulating Biomarkers of Tryptophan and the Kynurenine Pathway and Lung Cancer Risk
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Chuang, Shu-Chun (author)
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Fanidi, Anouar (author)
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Ueland, Per Magne (author)
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Relton, Caroline (author)
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Midttun, Oivind (author)
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Vollset, Stein Emil (author)
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Gunter, Marc J. (author)
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Seckl, Michael J. (author)
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Travis, Ruth C. (author)
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Wareham, Nicholas (author)
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Trichopoulou, Antonia (author)
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Lagiou, Pagona (author)
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Trichopoulos, Dimitrios (author)
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Peeters, Petra H. M. (author)
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Bueno-de-Mesquita, H. Bas (author)
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Boeing, Heiner (author)
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Wientzek, Angelika (author)
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Kuehn, Tilman (author)
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Kaaks, Rudolf (author)
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Tumino, Rosario (author)
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Agnoli, Claudia (author)
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Palli, Domenico (author)
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Naccarati, Alessio (author)
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Ardanaz Aicua, Eva (author)
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Sanchez, Maria-Jose (author)
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Ramon Quiros, Jose (author)
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Chirlaque, Maria-Dolores (author)
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Agudo, Antonio (author)
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- Johansson, Mikael (author)
- Umeå universitet,Onkologi
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- Grankvist, Kjell (author)
- Umeå universitet,Institutionen för medicinsk biovetenskap
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Boutron-Ruault, Marie-Christine (author)
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Clavel-Chapelon, Francoise (author)
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Fagherazzi, Guy (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Riboli, Elio (author)
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Brennan, Paul J. (author)
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Vineis, Paolo (author)
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Johansson, Mattias (author)
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(creator_code:org_t)
- 2014
- 2014
- English.
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In: Cancer Epidemiology, Biomarkers and Prevention. - 1055-9965 .- 1538-7755. ; 23:3, s. 461-468
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: Imbalances in tryptophan metabolism have been linked to cancer-related immune escape and implicated in several cancers, including lung cancer. Methods: We conducted a nested case-control study within the European Prospective Investigation into Cancer andNutrition (EPIC) that included 893 incident lung cancer cases and 1,748matched controls. Circulating levels of tryptophan and six of its metabolites were measured and evaluated in relation to lung cancer risk. Results: Tryptophan (P-trend = 2 Chi 10(-5)) and the kynurenine/ tryptophan ratio (KTR; P-trend 4 Chi 10(-5)) were associated with lung cancer risk overall after adjusting for established risk factors. The ORs comparing the fifth and first quintiles (OR5th (vs. 1st)) were 0.52 [ 95% confidence interval (CI), 0.37-0.74] for tryptophan and 1.74 (95% CI, 1.24-2.45) for KTR. After adjusting for plasma methionine (available fromprevious work, which was strongly correlated with tryptophan), the associations of tryptophan (adjusted P-trend 0.13) and KTR (P-trend = 0.009) were substantially attenuated. KTR was positively associated with squamous cell carcinoma, the OR5th vs. 1st being 2.83 (95% CI, 1.62-4.94, P-trend -3 Chi 10(-5)) that was only marginally affected by adjusting for methionine. Conclusions: This study indicates that biomarkers of tryptophan metabolism are associated with subsequent lung cancer risk. Although this result would seem consistent with the immune system having a role in lung cancer development, the overall associations were dependent on methionine, and further studies are warranted to further elucidate the importance of these metabolites in lung cancer etiology. Impact: This is the first prospective study investigating the tryptophan pathway in relation to lung cancer risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Chuang, Shu-Chun
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Fanidi, Anouar
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Ueland, Per Magn ...
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Relton, Caroline
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Midttun, Oivind
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Vollset, Stein E ...
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show more...
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Gunter, Marc J.
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Seckl, Michael J ...
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Travis, Ruth C.
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Wareham, Nichola ...
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Trichopoulou, An ...
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Lagiou, Pagona
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Trichopoulos, Di ...
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Peeters, Petra H ...
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Bueno-de-Mesquit ...
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Boeing, Heiner
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Wientzek, Angeli ...
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Kuehn, Tilman
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Kaaks, Rudolf
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Tumino, Rosario
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Agnoli, Claudia
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Palli, Domenico
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Naccarati, Aless ...
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Ardanaz Aicua, E ...
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Sanchez, Maria-J ...
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Ramon Quiros, Jo ...
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Chirlaque, Maria ...
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Agudo, Antonio
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Johansson, Mikae ...
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Grankvist, Kjell
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Boutron-Ruault, ...
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Clavel-Chapelon, ...
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Fagherazzi, Guy
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Weiderpass, Elis ...
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Riboli, Elio
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Brennan, Paul J.
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Vineis, Paolo
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Johansson, Matti ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
- Articles in the publication
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Cancer Epidemiol ...
- By the university
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Umeå University
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Karolinska Institutet