Vitamin D, PTH, and calcium in relation to survival following prostate cancer

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Fältnamn	Indikatorer	Metadata
000		04544naa a2200325 4500
001		oai:lup.lub.lu.se:a9234fff-0ce0-4651-be0f-7ace81cebbe2
003		SwePub
008		160418s2016 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/a9234fff-0ce0-4651-be0f-7ace81cebbe22 URI
024	7	a https://doi.org/10.1007/s10552-016-0740-72 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Brändstedt, Johanu Lund University,Lunds universitet,Urologi,Forskargrupper vid Lunds universitet,Urology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-jbt
245	1 0	a Vitamin D, PTH, and calcium in relation to survival following prostate cancer
264		c 2016-03-29
264	1	b Springer Science and Business Media LLC,c 2016
520		a PURPOSE: Epidemiological studies suggest that low levels of vitamin D constitute a risk factor for prostate cancer. However, the results are conflicting, perhaps because prostate cancer is a very heterogeneous disease. More recent studies have focused on cancer progression and mortality. Vitamin D is closely related to both calcium metabolism and parathyroid hormone (PTH) levels, and all three factors have been implicated in prostate cancer.METHODS: We examined the associations between pre-diagnostic serum levels of vitamin D (25OHD), PTH, and calcium and mortality among 943 participants within the Malmö Diet and Cancer Study, who were diagnosed with prostate cancer. The mean time from diagnosis until the end of followup was 9.1 years (SD 4.5), and the mean time from inclusion until end of follow-up was 16.6 years (SD 4.9). The analytes were divided into quartiles, and the risk of death from prostate cancer was analyzed using Cox proportional hazard analysis, yielding hazards ratios (HR) with 95 % confidence intervals. The models were adjusted for season and year of inclusion, age at baseline, age at diagnosis, body mass index (BMI), and tumor characteristics (TNM and Gleason score).RESULTS: We observed a trend toward a lower prostate-specific mortality with 25OHD >85 nmol/L in the unadjusted analysis. This became statistically significantly in the third quartile of 25OHD (85-102 nmol/L) compared to the first (<68 nmol/L), HR 0.54 (0.34-0.85) when adjusting for age, time of inclusion, and BMI. The association was further strengthened when adjusted for age at diagnosis, Gleason score, and TNM classification with a HR in Q3 0.36 (0.22-0.60). p for trend was 0.03. Regarding calcium, there was a significantly lower HR for the second quartile (2.35-2.39 mmol/L) compared to the first (≤2.34 mmol/L) with a HR of 0.54 (0.32-0.86) in the unadjusted analysis. However, this association disappeared when adjusting for tumor characteristics. There were no associations between levels of PTH and prostate cancer mortality.CONCLUSION: This study shows that levels of pre-diagnostic vitamin D above 85 nmol/L may improve survival in men with prostate cancer.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
700	1	a Almquist, Martinu Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)kir-mal
700	1	a Manjer, Jonasu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)smi-jma
700	1	a Malm, Johanu Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Department of Translational Medicine,Faculty of Medicine,Clinical Chemistry, Malmö,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)klke-jma
710	2	a Urologib Forskargrupper vid Lunds universitet4 org
773	0	t Cancer Causes and Controld : Springer Science and Business Media LLCg 27:5, s. 669-677q 27:5<669-677x 1573-7225x 0957-5243
856	4	u http://dx.doi.org/10.1007/s10552-016-0740-7y FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/a9234fff-0ce0-4651-be0f-7ace81cebbe2
856	4 8	u https://doi.org/10.1007/s10552-016-0740-7

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Av författaren/redakt...: Brändstedt, Joha ...; Almquist, Martin; Manjer, Jonas; Malm, Johan

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