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Sökning: (WFRF:(Bergström Petra)) mspu:(article) > (2010-2014) > Increased cell-medi...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04533naa a2200757 4500 | |
| 001 | oai:gup.ub.gu.se/159312 | |
| 003 | SwePub | |
| 008 | 240528s2011 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:122314832 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/1593122 URI |
| 024 | 7 | a https://doi.org/10.1128/CVI.00333-102 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1223148322 URI |
| 040 | a (SwePub)gud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Franzen-Röhl, Elisabethu Karolinska Institutet4 aut |
| 245 | 1 0 | a Increased cell-mediated immune responses in patients with recurrent herpes simplex virus type 2 meningitis. |
| 264 | 1 | c 2011 |
| 520 | a The clinical picture of herpes simplex virus type 2 (HSV-2) infection includes genital blisters and less frequently meningitis, and some individuals suffer from recurrent episodes of these manifestations. We hypothesized that adaptive and/or innate immune functional deficiencies may be a major contributing factor in susceptibility to recurrent HSV-2 meningitis. Ten patients with recurrent HSV-2 meningitis were studied during clinical remission. For comparison, 10 patients with recurrent genital HSV infections as well as 21 HSV-seropositive and 19 HSV-seronegative healthy blood donors were included. HSV-specific T cell blasting and cytokine secretion were evaluated in whole blood cultures. HSV-2-induced NK cell gamma interferon production, dendritic cell Toll-like receptor (TLR) expression, and TLR agonist-induced alpha interferon secretion were analyzed. Patients with recurrent HSV-2 meningitis had elevated T cell blasting and Th1 and Th2 cytokine production in response to HSV antigens compared to those of patients with recurrent genital infections. A somewhat increased NK cell response, increased dendritic cell expression of TLR3 and -9, and increased TLR-induced alpha interferon responses were also noted. Contrary to our expectation, recurrent HSV-2 meningitis patients have increased HSV-specific adaptive and innate immune responses, raising the possibility of immune-mediated pathology in the development of recurrent HSV2 meningitis. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
| 653 | a Adult | |
| 653 | a Cytokines | |
| 653 | a secretion | |
| 653 | a Dendritic Cells | |
| 653 | a immunology | |
| 653 | a Female | |
| 653 | a Gene Expression | |
| 653 | a Herpes Simplex | |
| 653 | a immunology | |
| 653 | a Herpesvirus 2 | |
| 653 | a Human | |
| 653 | a immunology | |
| 653 | a Humans | |
| 653 | a Immunity | |
| 653 | a Cellular | |
| 653 | a Killer Cells | |
| 653 | a Natural | |
| 653 | a immunology | |
| 653 | a Male | |
| 653 | a Meningitis | |
| 653 | a Viral | |
| 653 | a immunology | |
| 653 | a Middle Aged | |
| 653 | a Recurrence | |
| 653 | a T-Lymphocytes | |
| 653 | a immunology | |
| 653 | a Toll-Like Receptors | |
| 653 | a immunology | |
| 700 | 1 | a Schepis, Danikau Karolinska Institutet4 aut |
| 700 | 1 | a Lagrelius, Maria4 aut |
| 700 | 1 | a Franck, Kristina4 aut |
| 700 | 1 | a Jones, Petra4 aut |
| 700 | 1 | a Liljeqvist, Jan-Åke,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine4 aut0 (Swepub:gu)xljanl |
| 700 | 1 | a Bergström, Tomas,d 1950u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine4 aut0 (Swepub:gu)xberto |
| 700 | 1 | a Aurelius, Elisabethu Karolinska Institutet4 aut |
| 700 | 1 | a Kärre, Klasu Karolinska Institutet4 aut |
| 700 | 1 | a Berg, Louiseu Karolinska Institutet4 aut |
| 700 | 1 | a Gaines, Hans4 aut |
| 710 | 2 | a Karolinska Institutetb Institutionen för biomedicin, avdelningen för infektionssjukdomar4 org |
| 773 | 0 | t Clinical and vaccine immunology : CVIg 18:4, s. 655-60q 18:4<655-60x 1556-679X |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/159312 |
| 856 | 4 8 | u https://doi.org/10.1128/CVI.00333-10 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:122314832 |
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