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FältnamnIndikatorerMetadata
00013097naa a2201033 4500
001oai:lup.lub.lu.se:4411a3d7-d562-40d9-b506-97c05465ab72
003SwePub
008201209s2021 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-177088
009oai:DiVA.org:uu-438950
024a https://lup.lub.lu.se/record/4411a3d7-d562-40d9-b506-97c05465ab722 URI
024a https://doi.org/10.1002/ijc.333392 DOI
024a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1770882 URI
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4389502 URI
040 a (SwePub)lud (SwePub)umud (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
100a Christakoudi, Sofiau King's College London,Imperial College London,Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus, London W2 1PG, England.;Kings Coll London, MRC Ctr Transplantat, London, England.4 aut
2451 0a Weight change in middle adulthood and risk of cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
264 c 2020-11-09
264 1b Wiley,c 2021
520 a Obesity is a risk factor for several major cancers. Associations of weight change in middle adulthood with cancer risk, however, are less clear. We examined the association of change in weight and body mass index (BMI) category during middle adulthood with 42 cancers, using multivariable Cox proportional hazards models in the European Prospective Investigation into Cancer and Nutrition cohort. Of 241 323 participants (31% men), 20% lost and 32% gained weight (>0.4 to 5.0 kg/year) during 6.9 years (average). During 8.0 years of follow-up after the second weight assessment, 20 960 incident cancers were ascertained. Independent of baseline BMI, weight gain (per one kg/year increment) was positively associated with cancer of the corpus uteri (hazard ratio [HR] = 1.14; 95% confidence interval: 1.05-1.23). Compared to stable weight (±0.4 kg/year), weight gain (>0.4 to 5.0 kg/year) was positively associated with cancers of the gallbladder and bile ducts (HR = 1.41; 1.01-1.96), postmenopausal breast (HR = 1.08; 1.00-1.16) and thyroid (HR = 1.40; 1.04-1.90). Compared to maintaining normal weight, maintaining overweight or obese BMI (World Health Organisation categories) was positively associated with most obesity-related cancers. Compared to maintaining the baseline BMI category, weight gain to a higher BMI category was positively associated with cancers of the postmenopausal breast (HR = 1.19; 1.06-1.33), ovary (HR = 1.40; 1.04-1.91), corpus uteri (HR = 1.42; 1.06-1.91), kidney (HR = 1.80; 1.20-2.68) and pancreas in men (HR = 1.81; 1.11-2.95). Losing weight to a lower BMI category, however, was inversely associated with cancers of the corpus uteri (HR = 0.40; 0.23-0.69) and colon (HR = 0.69; 0.52-0.92). Our findings support avoiding weight gain and encouraging weight loss in middle adulthood.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
653 a BMI change
653 a cancer
653 a middle adulthood
653 a weight gain
653 a weight loss
653 a BMI change
700a Pagoni, Panagiotau University of Bristol,University of Ioannina,Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina, Greece.;Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England.;Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England.4 aut
700a Ferrari, Pietrou International Agency for Research on Cancer, World Health Organization,WHO, Int Agcy Res Canc, Lyon, France.4 aut
700a Cross, Amanda J.u Imperial College London,Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus, London W2 1PG, England.4 aut
700a Tzoulaki, Ioannau Imperial College London,University of Ioannina,Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus, London W2 1PG, England.;Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina, Greece.4 aut
700a Muller, David C.u Imperial College London,Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus, London W2 1PG, England.4 aut
700a Weiderpass, Elisabeteu International Agency for Research on Cancer, World Health Organization,WHO, Int Agcy Res Canc, Lyon, France.4 aut
700a Freisling, Heinzu International Agency for Research on Cancer, World Health Organization,WHO, Int Agcy Res Canc, Lyon, France.4 aut
700a Murphy, Neilu International Agency for Research on Cancer, World Health Organization,WHO, Int Agcy Res Canc, Lyon, France.4 aut
700a Dossus, Laureu International Agency for Research on Cancer, World Health Organization,WHO, Int Agcy Res Canc, Lyon, France.4 aut
700a Turzanski Fortner, Reneeu German Cancer Research Centre,German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.4 aut
700a Agudo, Antoniou IDIBELL LHospitalet de Llobregat, Unit Nutr & Canc, Canc Epidemiol Res Program, Catalan Inst Oncol, Barcelona, Spain.,Catalan Institute of Oncology4 aut
700a Overvad, Kimu Aarhus University,Aalborg University Hospital,Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark.;Aalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark.4 aut
700a Perez-Cornago, Aurorau University of Oxford,Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.4 aut
700a Key, Timothy J.u University of Oxford,Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.4 aut
700a Brennan, Paulu International Agency for Research on Cancer, World Health Organization,WHO, Int Agcy Res Canc, Lyon, France.4 aut
700a Johansson, Mattiasu International Agency for Research on Cancer, World Health Organization,WHO, Int Agcy Res Canc, Lyon, France.4 aut
700a Tjønneland, Anneu Danish Cancer Society,Danish Canc Soc Res Ctr, Copenhagen, Denmark.4 aut
700a Halkjær, Jytteu Danish Cancer Society,Danish Canc Soc Res Ctr, Copenhagen, Denmark.4 aut
700a Boutron-Ruault, Marie Christineu University of Paris-Saclay,Univ Paris Sud, Univ Paris Saclay, Equipe Exposome Heredite Canc & Sante, INSERM,UVSQ,CESP Gustave Roussy, Villejuif, France.4 aut
700a Artaud, Fannyu University of Paris-Saclay,Univ Paris Sud, Univ Paris Saclay, Equipe Exposome Heredite Canc & Sante, INSERM,UVSQ,CESP Gustave Roussy, Villejuif, France.4 aut
700a Severi, Gianlucau University of Paris-Saclay,University of Florence,Univ Paris Sud, Univ Paris Saclay, Equipe Exposome Heredite Canc & Sante, INSERM,UVSQ,CESP Gustave Roussy, Villejuif, France.;Univ Florence, Dept Stat Comp Sci & Applicat G Parenti DISIA, Florence, Italy.4 aut
700a Kaaks, Rudolfu German Cancer Research Centre,German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.4 aut
700a Schulze, Matthias B.u University of Potsdam,German Institute of Human Nutrition,German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany.;Univ Potsdam, Inst Nutr Sci, Nuthetal, Germany.4 aut
700a Bergmann, Manuela M.u German Institute of Human Nutrition,German Inst Human Nutr Potsdam Rehbrucke DIfE, Dept Epidemiol, Nuthetal, Germany.4 aut
700a Masala, Giovannau Institute for Cancer Research, Prevention and Clinical Network (ISPRO),ISPRO, Canc Risk Factors & Life Style Epidemiol Unit, Inst Canc Res Prevent & Clin Network, Florence, Italy.4 aut
700a Grioni, Sarau Istituto Nazionale dei Tumori,Fdn IRCCS Ist Nazl Tumori Milano, Epidemiol & Prevent Unit, Milan, Italy.4 aut
700a Simeon, Vittoriou University of Campania Luigi Vanvitelli,Univ LVanvitelli, Dept Mental Phys Hlth & Prevent Med, Naples, Italy.4 aut
700a Tumino, Rosariou Provincial Health Authority (ASP) Ragusa,Prov Hlth Author ASP Ragusa, Canc Registry & Histopathol Dept, Ragusa, Italy.4 aut
700a Sacerdote, Carlottau Citta' della Salute e della Scienza Hospital-University of Turin,Citta Salute & Sci Univ Hosp, Unit Canc Epidemiol, Turin, Italy.;Ctr Canc Prevent CPO, Turin, Italy.4 aut
700a Skeie, Guriu UiT The Arctic University of Norway, Tromsø,UiT Arctic Univ Norway, Dept Community Med, Tromso, Norway.4 aut
700a Rylander, Charlottau UiT The Arctic University of Norway, Tromsø,UiT Arctic Univ Norway, Dept Community Med, Tromso, Norway.4 aut
700a Borch, Kristin Benjaminsenu UiT The Arctic University of Norway, Tromsø,UiT Arctic Univ Norway, Dept Community Med, Tromso, Norway.4 aut
700a Quirós, J. Ramónu Publ Hlth Directorate, Asturias, Spain.4 aut
700a Rodriguez-Barranco, Miguelu Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP),Escuela Andaluza Salud Publ EASP, Granada, Spain.;Inst Invest Biosanitaria ibs GRANADA, Granada, Spain.;Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain.4 aut
700a Chirlaque, Maria Doloresu CIBER Epidemiology and Public Health (CIBERESP),University of Murcia,Murcia Regional Health Council,Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain.;IMIB Arrixaca, Reg Hlth Council, Dept Epidemiol, Murcia, Spain.;Univ Murcia, Dept Hlth & Social Sci, Murcia, Spain.4 aut
700a Ardanaz, Evau CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA),Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain.;Navarra Publ Hlth Inst, Pamplona, Spain.;Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain.4 aut0 (Swepub:lu)extLU-05
700a Amiano, Pilaru CIBER Epidemiology and Public Health (CIBERESP),Biodonostia Health Research Institute,Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain.;BioDonostia Researach Inst, Publ Hlth Div Gipuzkoa, San Sebastian, Spain.4 aut
700a Drake, Isabelu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Diabetes - Cardiovascular Disease,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Dept Clin Sci Malmö, Malmö, Sweden.4 aut0 (Swepub:lu)med-ihm
700a Stocks, Tanjau Lund University,Lunds universitet,Registerbaserad epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Register-based epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Dept Clin Sci Lund, Lund, Sweden.4 aut0 (Swepub:lu)med-tss
700a Häggström, Christelu Uppsala universitet,Umeå universitet,Uppsala University,Umeå University,Enheten för biobanksforskning,Department of Surgical Science, Uppsala University, Uppsala, Sweden,Endokrinkirurgi,Umeå Univ, Dept Biobank Res, Umeå, Sweden.4 aut0 (Swepub:uu)chrha650
700a Harlid, Sophiau Umeå universitet,Umeå University,Onkologi,Umeå Univ, Dept Radiat Sci, Umeå, Sweden.4 aut0 (Swepub:umu)soha0105
700a Ellingjord-Dale, Mereteu Imperial College London,Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus, London W2 1PG, England.4 aut
700a Riboli, Eliou Imperial College London,Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus, London W2 1PG, England.4 aut
700a Tsilidis, Konstantinos K.u University of Ioannina,Imperial College London,Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus, London W2 1PG, England.;Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina, Greece.4 aut
710a King's College Londonb Imperial College London4 org
773t International Journal of Cancerd : Wileyg 148:7, s. 1637-1651q 148:7<1637-1651x 0020-7136x 1097-0215
856u http://dx.doi.org/10.1002/ijc.33339x freey FULLTEXT
856u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.33339
856u https://doi.org/10.1002/ijc.33339y Fulltext
856u https://umu.diva-portal.org/smash/get/diva2:1505739/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print
856u https://uu.diva-portal.org/smash/get/diva2:1540536/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://lup.lub.lu.se/record/4411a3d7-d562-40d9-b506-97c05465ab72
8564 8u https://doi.org/10.1002/ijc.33339
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-177088
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-438950

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