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FältnamnIndikatorerMetadata
00004807naa a2200505 4500
001oai:lup.lub.lu.se:50fb293f-4022-48f1-8c9f-2b13c062215f
003SwePub
008160401s2014 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/48653972 URI
0247 a https://doi.org/10.1111/pedi.121512 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Lundgren, Markusu Central Hospital Kristianstad4 aut0 (Swepub:lu)med-mn2
2451 0a Reduced morbidity at diagnosis and improved glycemic control in children previously enrolled in DiPiS follow-up
264 c 2014-05-13
264 1b Hindawi Limited,c 2014
520 a Aims/hypothesis: Children participating in longitudinal type 1 diabetes prediction studies were reported to have less severe disease at diabetes diagnosis. Our aim was to investigate children who from birth participated in the Diabetes Prediction in Skane (DiPiS) study for metabolic status at diagnosis and then continued to be followed for 2 yr of regular clinical care. Methods: Children, followed in DiPiS before diagnosis, were compared to children in the same birth cohort, who did not participate in follow-up. Metabolic status, symptoms at diagnosis as well as hemoglobin A1c (HbA1c) and doses of insulin at 3, 6, 12, and 24 months after diagnosis were compared. Results: Children, followed in DiPiS and diagnosed at 2-12 yr of age, had 0.8% (9 mmol/mol) lower HbA1c at diagnosis than those who were not followed (p=0.006). At diagnosis, fewer DiPiS children had symptoms (p=0.014) and ketoacidosis at diagnosis were reduced (2% compared to 18%, p=0.005). During regular clinical care, HbA1c levels for the DiPiS children remained lower both at 12 (0.4% (4 mmol/mol); p=0.009) and 24 months (0.8% (9 mmol/mol) p < 0.001) after diagnosis, despite no difference in total daily insulin between the two groups. Conclusions: Participation in prospective follow-up before diagnosis of type 1 diabetes leads to earlier diagnosis with fewer symptoms, decreased incidence of ketoacidosis as well as better metabolic control up to 2 yr after diagnosis. Our data indicate that metabolic control at the time of diabetes diagnosis is important for early metabolic control possibly affecting the risk of long-term complications.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
653 a diabetic ketoacidosis
653 a follow-up studies
653 a HbA1c
653 a type 1 diabetes
7001 a Sahlin, Åsau Blekinge Hospital4 aut
7001 a Svensson, Camillau Central Hospital Kristianstad4 aut0 (Swepub:lu)ca6415bo
7001 a Carlsson, Annelieu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)med-acs
7001 a Cedervall, Elisabethu Ängelholm Hospital4 aut
7001 a Jönsson, Björnu Ystad Hospital4 aut
7001 a Jönsson, Idau Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine4 aut0 (Swepub:lu)med-ihs
7001 a Larsson, Karinu Central Hospital Kristianstad4 aut
7001 a Lernmark, Åkeu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)endo-ale
7001 a Neiderud, Janu Helsingborg Hospital4 aut0 (Swepub:lu)med-jnu
7001 a Vigård, Toreu Ystad Hospital4 aut0 (Swepub:lu)med-tva
7001 a Larsson, Helenau Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)pedi-hla
7102 a Central Hospital Kristianstadb Blekinge Hospital4 org
7730 t Pediatric Diabetesd : Hindawi Limitedg 15:7, s. 494-501q 15:7<494-501x 1399-543X
8564 u http://dx.doi.org/10.1111/pedi.12151y FULLTEXT
8564 u https://europepmc.org/articles/pmc4190091?pdf=render
8564 8u https://lup.lub.lu.se/record/4865397
8564 8u https://doi.org/10.1111/pedi.12151

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