Search: (WFRF:(Drevon Christian A)) pers:(Roche Helen M.) >
Effects of dietary ...
Effects of dietary fat on insulin secretion in subjects with the metabolic syndrome
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- Gulseth, Hanne L. (author)
- Univ Oslo, Oslo Univ Hosp, Dept Endocrinol Morbid Obes & Prevent Med, Oslo, Norway;Univ Oslo, Fac Med, Oslo, Norway;Univ Oslo, Fac Med, Inst Basic Med Sci, Dept Nutr, Oslo, Norway;Norwegian Inst Publ Hlth, Dept Chron Dis & Ageing, Oslo, Norway
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- Gjelstad, Ingrid M. F. (author)
- Univ Oslo, Oslo Univ Hosp, Dept Endocrinol Morbid Obes & Prevent Med, Oslo, Norway;Univ Oslo, Fac Med, Oslo, Norway;Univ Oslo, Fac Med, Inst Basic Med Sci, Dept Nutr, Oslo, Norway
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- Tiereny, Audrey C. (author)
- Univ Coll Dublin, UCD Conway Inst, Nutrigen Res Grp, Dublin, Ireland;Univ Coll Dublin, UCD Inst Food & Hlth, Sch Publ Hlth Physiotherapy & Sports Sci, Dublin, Ireland;Univ Limerick, Sch Allied Hlth, Limerick, Ireland;La Trobe Univ, Sch Allied Hlth, Melbourne, Vic, Australia
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- McCarthy, Danielle (author)
- Univ Reading, Dept Food Biosci, Hugh Sinclair Unit Human Nutr, Reading, Berks, England;Queens Univ Belfast, Northern Ireland Technol Ctr, Inst Global Food Secur, Belfast, Antrim, North Ireland
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- Lovegrove, Julie A. (author)
- Univ Reading, Dept Food Biosci, Hugh Sinclair Unit Human Nutr, Reading, Berks, England;Univ Reading, Inst Cardiovasc & Metab Res, Reading, Berks, England
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- Defoort, Catherine (author)
- Aix Marseille Univ, INSERM, INRA, C2VN, Marseille, France
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- Blaak, Ellen E. (author)
- Maastricht Univ, Med Ctr, Sch Nutr Toxicol & Metab, NUTRIM, Maastricht, Netherlands
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- Lopez-Miranda, Jose (author)
- Univ Cordoba, Hosp Univ Reina Sofia, Inst Maimonides Invest Biomed Cordoba IMIBIC, Lipids & Atherosclerosis Res Unit, Madrid, Spain;Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain
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- Dembinska-Kiec, Aldona (author)
- Jagiellonian Univ, Dept Clin Biochem, Med Coll, Krakow, Poland
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- Risérus, Ulf, 1967- (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Roche, Helen M. (author)
- Univ Coll Dublin, UCD Conway Inst, Nutrigen Res Grp, Dublin, Ireland;Univ Coll Dublin, UCD Inst Food & Hlth, Sch Publ Hlth Physiotherapy & Sports Sci, Dublin, Ireland
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- Drevon, Christian A. (author)
- Univ Oslo, Fac Med, Inst Basic Med Sci, Dept Nutr, Oslo, Norway
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- Birkeland, Kare, I (author)
- Univ Oslo, Oslo Univ Hosp, Dept Endocrinol Morbid Obes & Prevent Med, Oslo, Norway;Univ Oslo, Fac Med, Oslo, Norway;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway
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(creator_code:org_t)
- BIOSCIENTIFICA LTD, 2019
- 2019
- English.
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In: European Journal of Endocrinology. - : BIOSCIENTIFICA LTD. - 0804-4643 .- 1479-683X. ; 180:5, s. 321-328
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objective: Impaired insulin secretion and action contribute to the development of type 2 diabetes. Dietary fat modification may improve insulin sensitivity, whereas the effect on insulin secretion is unclear. We investigated the effect of dietary fat modification on insulin secretion in subjects with the metabolic syndrome.Design: In a 12-week pan-European parallel, randomized controlled dietary intervention trial (LIPGENE), 486 subjects were assigned to four isoenergetic diets: high-fat diets rich in saturated fat (HSFA) or monounsaturated fat (HMUFA) or low-fat, high-complex carbohydrate diets with (LFHCC n-3) or without (LFHCC control) 1.2 g/day of n-3 PUFA supplementation. Insulin secretion was estimated as acute insulin response to glucose (AIRg) and disposition index (DI), modeled from an intravenous glucose tolerance test.Results: There were no overall effect of the dietary intervention on AIRg and DI in the total cohort, in neither the highfat nor LFHCC groups. We observed significant diet*fasting glucose category interactions for AIRg (P = 0.021) and DI (P = 0.001) in the high-fat groups. In subjects with normal fasting glucose and preserved first phase insulin secretion, the HMUFA diet increased, whereas the HSFA diet reduced AIRg (P = 0.015) and DI (P = 0.010).Conclusions: The effects of dietary fat modification on insulin secretion were minor, and only evident in normoglycemic subjects. In this case, the HMUFA diet improved AIRg and DI, as compared to the HSFA diet.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Gulseth, Hanne L ...
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Gjelstad, Ingrid ...
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Tiereny, Audrey ...
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McCarthy, Daniel ...
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Lovegrove, Julie ...
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Defoort, Catheri ...
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Blaak, Ellen E.
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Lopez-Miranda, J ...
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Dembinska-Kiec, ...
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Risérus, Ulf, 19 ...
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Roche, Helen M.
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Drevon, Christia ...
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Birkeland, Kare, ...
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Uppsala University