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Sökning: onr:"swepub:oai:DiVA.org:umu-67055" > Ischemic stroke is ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005551naa a2200997 4500
001oai:DiVA.org:umu-67055
003SwePub
008130312s2013 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-670552 URI
0247 a https://doi.org/10.1002/ana.238382 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Williams, Frances M. K.4 aut
2451 0a Ischemic stroke is associated with the ABO locus :b the EuroCLOT study
264 c 2013-02-04
264 1b Wiley-Blackwell,c 2013
338 a print2 rdacarrier
500 a Errata Annals of Neurology, 2014: 75 (1), 166-167. doi:10.1002/ana.24105
520 a Objective: End-stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end-stage coagulation in healthy volunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype. Methods: Common genetic variants identified through genome-wide association studies of coagulation factors and fibrin structure/function in healthy twins (n = 2,100, Stage 1) were examined in ischemic stroke (n = 4,200 cases) using 2 independent samples of European ancestry (Stage 2). A third clinical collection having stroke subtyping (total 8,900 cases, 55,000 controls) was used for replication (Stage 3). Results: Stage 1 identified 524 single nucleotide polymorphisms (SNPs) from 23 linkage disequilibrium blocks having significant association (p < 5 x 10(-8)) with 1 or more coagulation/fibrin phenotypes. The most striking associations included SNP rs5985 with factor XIII activity (p = 2.6 x 10(-186)), rs10665 with FVII (p = 2.4 x 10(-47)), and rs505922 in the ABO gene with both von Willebrand factor (p = 4.7 x 10(-57)) and factor VIII (p = 1.2 x 10(-36)). In Stage 2, the 23 independent SNPs were examined in stroke cases/noncases using MOnica Risk, Genetics, Archiving and Monograph (MORGAM) and Wellcome Trust Case Control Consortium 2 collections. SNP rs505922 was nominally associated with ischemic stroke (odds ratio = 0.94, 95% confidence interval = 0.88-0.99, p = 0.023). Independent replication in Meta-Stroke confirmed the rs505922 association with stroke, beta (standard error, SE) = 0.066 (0.02), p = 0.001, a finding specific to large-vessel and cardioembolic stroke (p = 0.001 and p = < 0.001, respectively) but not seen with small-vessel stroke (p = 0.811). Interpretation: ABO gene variants are associated with large-vessel and cardioembolic stroke but not small-vessel disease. This work sheds light on the different pathogenic mechanisms underpinning stroke subtype.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
7001 a Carter, Angela M.4 aut
7001 a Hysi, Pirro G.4 aut
7001 a Surdulescu, Gabriela4 aut
7001 a Hodgkiss, Dylan4 aut
7001 a Soranzo, Nicole4 aut
7001 a Traylor, Matthew4 aut
7001 a Bevan, Steve4 aut
7001 a Dichgans, Martin4 aut
7001 a Rothwell, Peter M. W.4 aut
7001 a Sudlow, Cathie4 aut
7001 a Farrall, Martin4 aut
7001 a Silander, Kaisa4 aut
7001 a Kaunisto, Mari4 aut
7001 a Wagner, Peter4 aut
7001 a Saarela, Olli4 aut
7001 a Kuulasmaa, Kari4 aut
7001 a Virtamo, Jarmo4 aut
7001 a Salomaa, Veikko4 aut
7001 a Amouyel, Philippe4 aut
7001 a Arveiler, Dominique4 aut
7001 a Ferrieres, Jean4 aut
7001 a Wiklund, Per-Gunnaru Umeå universitet,Medicin4 aut0 (Swepub:umu)pewi0010
7001 a Ikram, M. Arfan4 aut
7001 a Hofman, Albert4 aut
7001 a Boncoraglio, Giorgio B.4 aut
7001 a Parati, Eugenio A.4 aut
7001 a Helgadottir, Anna4 aut
7001 a Gretarsdottir, Solveig4 aut
7001 a Thorsteinsdottir, Unnur4 aut
7001 a Thorleifsson, Gudmar4 aut
7001 a Stefansson, Kari4 aut
7001 a Seshadri, Sudha4 aut
7001 a DeStefano, Anita4 aut
7001 a Gschwendtner, Andreas4 aut
7001 a Psaty, Bruce4 aut
7001 a Longstreth, Will4 aut
7001 a Mitchell, Braxton D.4 aut
7001 a Cheng, Yu-Ching4 aut
7001 a Clarke, Robert4 aut
7001 a Ferrario, Marco4 aut
7001 a Bis, Joshua C.4 aut
7001 a Levi, Christopher4 aut
7001 a Attia, John4 aut
7001 a Holliday, Elizabeth G.4 aut
7001 a Scott, Rodney J.4 aut
7001 a Fornage, Myriam4 aut
7001 a Sharma, Pankaj4 aut
7001 a Furie, Karen L.4 aut
7001 a Rosand, Jonathan4 aut
7001 a Nalls, Mike4 aut
7001 a Meschia, James4 aut
7001 a Mosely, Thomas H.4 aut
7001 a Evans, Alun4 aut
7001 a Palotie, Aarno4 aut
7001 a Markus, Hugh S.4 aut
7001 a Grant, Peter J.4 aut
7001 a Spector, Tim D.4 aut
7102 a Umeå universitetb Medicin4 org
7730 t Annals of Neurologyd : Wiley-Blackwellg 73:1, s. 16-31q 73:1<16-31x 0364-5134x 1531-8249
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ana.23838
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-67055
8564 8u https://doi.org/10.1002/ana.23838

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