Meta-analysis identifies six new susceptibility loci for atrial fibrillation

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Fältnamn	Indikatorer	Metadata
000		06185naa a2201357 4500
001		oai:lup.lub.lu.se:13666abe-844c-465c-877e-0c7b0f3582c4
003		SwePub
008		160401s2012 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/29067702 URI
024	7	a https://doi.org/10.1038/ng.22612 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Ellinor, Patrick T.4 aut
245	1 0	a Meta-analysis identifies six new susceptibility loci for atrial fibrillation
264		c 2012-04-29
264	1	b Springer Science and Business Media LLC,c 2012
520		a Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death(1). We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 x 10(-8)). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
700	1	a Lunetta, Kathryn L.4 aut
700	1	a Albert, Christine M.4 aut
700	1	a Glazer, Nicole L.4 aut
700	1	a Ritchie, Marylyn D.4 aut
700	1	a Smith, Albert V.4 aut
700	1	a Arking, Dan E.4 aut
700	1	a Mueller-Nurasyid, Martina4 aut
700	1	a Krijthe, Bouwe P.4 aut
700	1	a Lubitz, Steven A.4 aut
700	1	a Bis, Joshua C.4 aut
700	1	a Chung, Mina K.4 aut
700	1	a Doerr, Marcus4 aut
700	1	a Ozaki, Kouichi4 aut
700	1	a Roberts, Jason D.4 aut
700	1	a Smith, Gustavu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)med-gvs
700	1	a Pfeufer, Arne4 aut
700	1	a Sinner, Moritz F.4 aut
700	1	a Lohman, Kurt4 aut
700	1	a Ding, Jingzhong4 aut
700	1	a Smith, Nicholas L.4 aut
700	1	a Smith, Jonathan D.4 aut
700	1	a Rienstra, Michiel4 aut
700	1	a Rice, Kenneth M.4 aut
700	1	a Van Wagoner, David R.4 aut
700	1	a Magnani, Jared W.4 aut
700	1	a Wakili, Reza4 aut
700	1	a Clauss, Sebastian4 aut
700	1	a Rotter, Jerome I.4 aut
700	1	a Steinbeck, Gerhard4 aut
700	1	a Launer, Lenore J.4 aut
700	1	a Davies, Robert W.4 aut
700	1	a Borkovich, Matthew4 aut
700	1	a Harris, Tamara B.4 aut
700	1	a Lin, Honghuang4 aut
700	1	a Voelker, Uwe4 aut
700	1	a Voelzke, Henry4 aut
700	1	a Milan, David J.4 aut
700	1	a Hofman, Albert4 aut
700	1	a Boerwinkle, Eric4 aut
700	1	a Chen, Lin Y.4 aut
700	1	a Soliman, Elsayed Z.4 aut
700	1	a Voight, Benjamin F.4 aut
700	1	a Li, Guo4 aut
700	1	a Chakravarti, Aravinda4 aut
700	1	a Kubo, Michiaki4 aut
700	1	a Tedrow, Usha B.4 aut
700	1	a Rose, Lynda M.4 aut
700	1	a Ridker, Paul M.4 aut
700	1	a Conen, David4 aut
700	1	a Tsunoda, Tatsuhiko4 aut
700	1	a Furukawa, Tetsushi4 aut
700	1	a Sotoodehnia, Nona4 aut
700	1	a Xu, Siyan4 aut
700	1	a Kamatani, Naoyuki4 aut
700	1	a Levy, Daniel4 aut
700	1	a Nakamura, Yusuke4 aut
700	1	a Parvez, Babar4 aut
700	1	a Mahida, Saagar4 aut
700	1	a Furie, Karen L.4 aut
700	1	a Rosand, Jonathan4 aut
700	1	a Muhammad, Raafia4 aut
700	1	a Psaty, Bruce M.4 aut
700	1	a Meitinger, Thomas4 aut
700	1	a Perz, Siegfried4 aut
700	1	a Wichmann, H-Erich4 aut
700	1	a Witteman, Jacqueline C. M.4 aut
700	1	a Kao, W. H. Linda4 aut
700	1	a Kathiresan, Sekar4 aut
700	1	a Roden, Dan M.4 aut
700	1	a Uitterlinden, Andre G.4 aut
700	1	a Rivadeneira, Fernando4 aut
700	1	a McKnight, Barbara4 aut
700	1	a Sjögren, Marketau Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-msj
700	1	a Newman, Anne B.4 aut
700	1	a Liu, Yongmei4 aut
700	1	a Gollob, Michael H.4 aut
700	1	a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
700	1	a Tanaka, Toshihiro4 aut
700	1	a Stricker, Bruno H. Ch4 aut
700	1	a Felix, Stephan B.4 aut
700	1	a Alonso, Alvaro4 aut
700	1	a Darbar, Dawood4 aut
700	1	a Barnard, John4 aut
700	1	a Chasman, Daniel I.4 aut
700	1	a Heckbert, Susan R.4 aut
700	1	a Benjamin, Emelia J.4 aut
700	1	a Gudnason, Vilmundur4 aut
700	1	a Kaeaeb, Stefan4 aut
710	2	a Kardiovaskulär forskning - hypertonib Forskargrupper vid Lunds universitet4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 44:6, s. 88-670q 44:6<88-670x 1546-1718x 1061-4036
856	4	u http://dx.doi.org/10.1038/ng.2261y FULLTEXT
856	4	u https://europepmc.org/articles/pmc3366038?pdf=render
856	4 8	u https://lup.lub.lu.se/record/2906770
856	4 8	u https://doi.org/10.1038/ng.2261

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Av författaren/redakt...: Ellinor, Patrick ...; Lunetta, Kathryn ...; Albert, Christin ...; Glazer, Nicole L ...; Ritchie, Marylyn ...; Smith, Albert V.; visa fler...; Arking, Dan E.; Mueller-Nurasyid ...; Krijthe, Bouwe P ...; Lubitz, Steven A ...; Bis, Joshua C.; Chung, Mina K.; Doerr, Marcus; Ozaki, Kouichi; Roberts, Jason D ...; Smith, Gustav; Pfeufer, Arne; Sinner, Moritz F ...; Lohman, Kurt; Ding, Jingzhong; Smith, Nicholas ...; Smith, Jonathan ...; Rienstra, Michie ...; Rice, Kenneth M.; Van Wagoner, Dav ...; Magnani, Jared W ...; Wakili, Reza; Clauss, Sebastia ...; Rotter, Jerome I ...; Steinbeck, Gerha ...; Launer, Lenore J ...; Davies, Robert W ...; Borkovich, Matth ...; Harris, Tamara B ...; Lin, Honghuang; Voelker, Uwe; Voelzke, Henry; Milan, David J.; Hofman, Albert; Boerwinkle, Eric; Chen, Lin Y.; Soliman, Elsayed ...; Voight, Benjamin ...; Li, Guo; Chakravarti, Ara ...; Kubo, Michiaki; Tedrow, Usha B.; Rose, Lynda M.; Ridker, Paul M.; Conen, David; Tsunoda, Tatsuhi ...; Furukawa, Tetsus ...; Sotoodehnia, Non ...; Xu, Siyan; Kamatani, Naoyuk ...; Levy, Daniel; Nakamura, Yusuke; Parvez, Babar; Mahida, Saagar; Furie, Karen L.; Rosand, Jonathan; Muhammad, Raafia; Psaty, Bruce M.; Meitinger, Thoma ...; Perz, Siegfried; Wichmann, H-Eric ...; Witteman, Jacque ...; Kao, W. H. Linda; Kathiresan, Seka ...; Roden, Dan M.; Uitterlinden, An ...; Rivadeneira, Fer ...; McKnight, Barbar ...; Sjögren, Marketa; Newman, Anne B.; Liu, Yongmei; Gollob, Michael ...; Melander, Olle; Tanaka, Toshihir ...; Stricker, Bruno ...; Felix, Stephan B ...; Alonso, Alvaro; Darbar, Dawood; Barnard, John; Chasman, Daniel ...; Heckbert, Susan ...; Benjamin, Emelia ...; Gudnason, Vilmun ...; Kaeaeb, Stefan; visa färre...

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Av lärosätet: Lunds universitet

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