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Combined effects of...
Combined effects of smoking and HPV16 in oropharyngeal cancer
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- Anantharaman, Devasena (author)
- Int Agcy Res Canc, Genet Epidemiol Grp, Lyon, France.,International Agency for Research on Cancer, World Health Organization
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- Muller, David C. (author)
- Int Agcy Res Canc, Genet Epidemiol Grp, Lyon, France.,International Agency for Research on Cancer, World Health Organization,University of Padova
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- Lagiou, Pagona (author)
- Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens, Greece.
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- Ahrens, Wolfgang (author)
- BIPS, Leibniz Inst Prevent Res & Epidemiol, Bremen, Germany.;Univ Bremen, Fac Math & Comp Sci, Bremen, Germany.,Leibniz Institute for Prevention Research and Epidemiology - BIPS GmbH
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- Holcatova, Ivana (author)
- Charles Univ Prague, Fac Med 1, Inst Hyg & Epidemiol, Prague, Czech Republic.,Charles University in Prague
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- Merletti, Franco (author)
- Univ Turin, Dept Med Sci, Canc Epidemiol Unit, Turin, Italy.,University of Turin
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- Kjaerheim, Kristina (author)
- Canc Registry Norway, Oslo, Norway.,Cancer Registry of Norway, Institute of Population-Based Cancer Research
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- Polesel, Jerry (author)
- CRO Aviano Natl Canc Inst, Unit Epidemiol & Biostat, Aviano, Italy.,CRO (Centro di Riferimento Oncologico) Aviano National Cancer Institute
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- Simonato, Lorenzo (author)
- Univ Padua, Dept Mol Med, Lab Publ Hlth & Populat Studies, Padua, Italy.,University of Padova
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- Canova, Cristina (author)
- Univ Padua, Dept Mol Med, Lab Publ Hlth & Populat Studies, Padua, Italy.
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- Castellsague, Xavier (author)
- CIBERESP, IDIBELL, ICO, Unit Infect & Canc, Barcelona, Spain.,L'Hospitalet de Llobregat, Barcelona
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- Macfarlane, Tatiana V. (author)
- Univ Aberdeen, Sch Med & Dent, Aberdeen, Scotland.,University of Aberdeen
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- Znaor, Ariana (author)
- Croatian Natl Inst Publ Hlth, Croatian Natl Canc Registry, Zagreb, Croatia.;Int Agcy Res Canc, Sect Canc Surveillance, Lyon, France.,Croatian National Institute of Public Health, Zagreb
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- Thomson, Peter (author)
- Newcastle Univ, Ctr Oral Hlth Res, Newcastle Upon Tyne, Tyne & Wear, England.,University of Newcastle upon Tyne
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- Robinson, Max (author)
- Newcastle Univ, Ctr Oral Hlth Res, Newcastle Upon Tyne, Tyne & Wear, England.,University of Newcastle upon Tyne
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- Conway, David I. (author)
- Univ Glasgow, Sch Dent, Coll Med Vet & Life Sci, Glasgow, Lanark, Scotland.,University of Glasgow
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- Healy, Claire M. (author)
- Trinity Coll Dublin, Sch Dent Sci, Dublin, Ireland.,Trinity College Dublin
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- Tjönneland, Anne (author)
- Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark.,Danish Cancer Society
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- Westin, Ulla (author)
- Lund University,Lunds universitet,Laryngoesofagologi, allergi och livskvalitet,Forskargrupper vid Lunds universitet,Laryngoesophagology, Allergy and Life Quality,Lund University Research Groups
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- Ekström, Johanna (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Klinisk mikrobiologi, Malmö,Internal Medicine - Epidemiology,Lund University Research Groups,Clinical Microbiology, Malmö
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- Chang-Claude, Jenny (author)
- German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.,German Cancer Research Centre
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- Kaaks, Rudolf (author)
- German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.,German Cancer Research Centre
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- Overvad, Kim (author)
- Inst Publ Hlth, Aarhus, Denmark.,Aarhus University
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- Drogan, Dagmar (author)
- German Inst Human Nutr Potsdam Rehbruecke DIfE, Nuthetal, Germany.,German Institute of Human Nutrition
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- Hallmans, Göran (author)
- Umeå University,Umeå universitet,Enheten för biobanksforskning
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- Laurell, Göran (author)
- Uppsala University,Uppsala universitet,Öron-, näs- och halssjukdomar
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- Bueno-de-Mesquita, H. B. (author)
- Natl Inst Publ Hlth & Environm RIVM, Dept Determinants Chron Dis DCD, Bilthoven, Netherlands.;Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands.;Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur, Malaysia.
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- Peeters, Petra H. (author)
- Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands.;Imperial Coll London, Sch Publ Hlth, MRC PHE, London, England.
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- Agudo, Antonio (author)
- ICO, Unit Nutr & Canc, Barcelona, Spain.,L'Hospitalet de Llobregat, Barcelona
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- Larranaga, Nerea (author)
- BIODonostia Res Inst, Basque Hlth Dept, Publ Hlth Div Gipuzkoa, San Sebastian, Spain.;CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain.,Biodonostia Health Research Institute,CIBER Epidemiology and Public Health (CIBERESP)
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- Travis, Ruth C. (author)
- Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.
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- Palli, Domenico (author)
- Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy.
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- Barricarte, Aurelio (author)
- CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain.;Navarre Publ Hlth Inst, Pamplona, Spain.,CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)
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- Trichopoulou, Antonia (author)
- Hellen Hlth Fdn, Athens, Greece.;Acad Athens, Bur Epidemiol Res, Athens, Greece.,Academy of Athens
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- George, Saitakis (author)
- Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens, Greece.;Hellen Hlth Fdn, Athens, Greece.,National and Kapodistrian University of Athens
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- Trichopoulos, Dimitrios (author)
- Hellen Hlth Fdn, Athens, Greece.;Acad Athens, Bur Epidemiol Res, Athens, Greece.;Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.,Harvard University,Academy of Athens
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- Ramon Quiros, J. (author)
- Publ Hlth Directorate Asturias, Oviedo, Spain.
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- Grioni, Sara (author)
- Fdn IRCCS, Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy.,Istituto Nazionale dei Tumori
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- Sacerdote, Carlotta (author)
- Univ Turin, Citta Salute & Sci Hosp, Canc Epidemiol Unit, Turin, Italy.;Ctr Canc Prevent CPO, Turin, Italy.,Centre for Cancer Epidemiology and Prevention (CPO Piemonte)
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- Navarro, Carmen (author)
- CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain.;IMIB Arrixaca, Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain.;Univ Murcia, Dept Hlth & Social Sci, Murcia, Spain.,University of Murcia,CIBER Epidemiology and Public Health (CIBERESP)
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- Sanchez, Maria-Jose (author)
- CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain.;Univ Granada, Inst Invest Biosanitaria, Granada, Spain.,University of Granada,CIBER Epidemiology and Public Health (CIBERESP)
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- Tumino, Rosario (author)
- Civ MP Arezzo Hosp, Canc Registry, Asp Ragusa, Ragusa, Italy.;Civ MP Arezzo Hosp, Histopathol Unit, Asp Ragusa, Ragusa, Italy.
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- Severi, Gianluca (author)
- Human Genet Fdn HuGeF, Turin, Italy.;Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic 3010, Australia.,University of Melbourne,Human Genetics Foundation (HuGeF)
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- Boutron-Ruault, Marie-Christine (author)
- INSERM, Ctr Res Epidemiol & Populat Hlth CESP, Villejuif, France.;Univ Paris 11, Villejuif, France.;Inst Gustave Roussy, Villejuif, France.,University of Paris-Saclay
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- Clavel-Chapelon, Francoise (author)
- INSERM, Ctr Res Epidemiol & Populat Hlth CESP, Villejuif, France.;Univ Paris 11, Villejuif, France.;Inst Gustave Roussy, Villejuif, France.
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- Panico, Salvatore (author)
- Univ Naples Federico II, Dipartimento Med Clin & Chirurgia, Naples, Italy.,University of Naples Federico II
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- Weiderpass, Elisabete (author)
- Karolinska Institutet,Folkhälsan Research Center,UiT The Arctic University of Norway, Tromsø,Cancer Registry of Norway, Institute of Population-Based Cancer Research
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- Lund, Eiliv (author)
- Arctic Univ Norway, Univ Tromso, Fac Hlth Sci, Dept Community Med, Tromso, Norway.,UiT The Arctic University of Norway, Tromsø
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- Gram, Inger T. (author)
- Arctic Univ Norway, Univ Tromso, Fac Hlth Sci, Dept Community Med, Tromso, Norway.,UiT The Arctic University of Norway, Tromsø
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- Riboli, Elio (author)
- Imperial Coll London, Sch Publ Hlth, London, England.,Imperial College London
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- Pawlita, Michael (author)
- German Canc Res Ctr, Heidelberg, Germany.,German Cancer Research Centre
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- Waterboer, Tim (author)
- German Canc Res Ctr, Heidelberg, Germany.,German Cancer Research Centre
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- Kreimer, Aimee R. (author)
- NCI, NIH, Bethesda, MD 20892 USA.,National Cancer Institute, NCI
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- Johansson, Mattias (author)
- Umeå universitet,Enheten för biobanksforskning,International Agency for Research on Cancer, World Health Organization
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- Brennan, Paul (author)
- Int Agcy Res Canc, Genet Epidemiol Grp, Lyon, France.,International Agency for Research on Cancer, World Health Organization
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Int Agcy Res Canc, Genet Epidemiol Grp, Lyon, France International Agency for Research on Cancer, World Health Organization (creator_code:org_t)
- 2016-05-19
- 2016
- English.
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In: International Journal of Epidemiology. - : Oxford University Press (OUP). - 0300-5771 .- 1464-3685. ; 45:3, s. 752-761
- Related links:
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Background: Although smoking and HPV infection are recognized as important risk factors for oropharyngeal cancer, how their joint exposure impacts on oropharyngeal cancer risk is unclear. Specifically, whether smoking confers any additional risk to HPV-positive oropharyngeal cancer is not understood.Methods: Using HPV serology as a marker of HPV-related cancer, we examined the interaction between smoking and HPV16 in 459 oropharyngeal (and 1445 oral cavity and laryngeal) cancer patients and 3024 control participants from two large European multicentre studies. Odds ratios and credible intervals [CrI], adjusted for potential confounders, were estimated using Bayesian logistic regression.Results: Both smoking [odds ratio (OR [CrI]: 6.82 [4.52, 10.29]) and HPV seropositivity (OR [CrI]: 235.69 [99.95, 555.74]) were independently associated with oropharyngeal cancer. The joint association of smoking and HPV seropositivity was consistent with that expected on the additive scale (synergy index [CrI]: 1.32 [0.51, 3.45]), suggesting they act as independent risk factors for oropharyngeal cancer.Conclusions: Smoking was consistently associated with increase in oropharyngeal cancer risk in models stratified by HPV16 seropositivity. In addition, we report that the prevalence of oropharyngeal cancer increases with smoking for both HPV16-positive and HPV16-negative persons. The impact of smoking on HPV16-positive oropharyngeal cancer highlights the continued need for smoking cessation programmes for primary prevention of head and neck cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Human papillomavirus
- tobacco smoking
- interaction
- head and neck cancer risk
- oropharynx cancer
- Journal Article
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Anantharaman, De ...
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Muller, David C.
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Lagiou, Pagona
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Ahrens, Wolfgang
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Holcatova, Ivana
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Merletti, Franco
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show more...
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Kjaerheim, Krist ...
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Polesel, Jerry
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Simonato, Lorenz ...
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Canova, Cristina
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Castellsague, Xa ...
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Macfarlane, Tati ...
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Znaor, Ariana
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Thomson, Peter
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Robinson, Max
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Conway, David I.
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Healy, Claire M.
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Tjönneland, Anne
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Westin, Ulla
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Ekström, Johanna
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Chang-Claude, Je ...
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Kaaks, Rudolf
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Overvad, Kim
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Drogan, Dagmar
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Hallmans, Göran
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Laurell, Göran
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Bueno-de-Mesquit ...
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Peeters, Petra H ...
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Agudo, Antonio
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Larranaga, Nerea
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Travis, Ruth C.
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Palli, Domenico
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Barricarte, Aure ...
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Trichopoulou, An ...
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George, Saitakis
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Trichopoulos, Di ...
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Ramon Quiros, J.
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Grioni, Sara
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Sacerdote, Carlo ...
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Navarro, Carmen
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Sanchez, Maria-J ...
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Tumino, Rosario
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Severi, Gianluca
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Boutron-Ruault, ...
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Clavel-Chapelon, ...
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Panico, Salvator ...
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Weiderpass, Elis ...
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Lund, Eiliv
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Gram, Inger T.
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Riboli, Elio
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Pawlita, Michael
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Waterboer, Tim
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Kreimer, Aimee R ...
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Johansson, Matti ...
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Brennan, Paul
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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Uppsala University
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Umeå University
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Lund University
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Karolinska Institutet