P2Y12 receptor inhibitors in patients with non-STelevation acute coronary syndrome in the real world : Use, patient selection, and outcomes from contemporary European registries

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P2Y12 receptor inhibitors in patients with non-STelevation acute coronary syndrome in the real world : Use, patient selection, and outcomes from contemporary European registries

Zeymer, Uwe (author): Klinikum Ludwigshafen

Widimsky, Petr (author): Charles University in Prague

Danchin, Nicolas (author): Hôpital Européen Georges-Pompidou

Lettino, Maddalena (author): Humanitas Research Hospital

Bardaji, Alfredo (author): Hospital Joan XXIII

Barrabes, Jose A. (author): Vall d'Hebron University Hospital

Cequier, Angel (author): Bellvitge University Hospital-IDIBELL

Claeys, Marc J. (author): Antwerp University Hospital

De Luca, Leonardo (author): European Hospital

Dörler, Jakob (author): Medical University of Innsbruck

Erlinge, David (author): Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital

Erne, Paul (author): University of Zurich

Goldstein, Patrick (author): Lille University Hospital

Koul, Sasha M. (author): Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital

Lemesle, Gilles (author): Lille University Hospital

Lüscher, Thomas F. (author): University of Zurich

Matter, Christian M. (author): University of Zurich

Montalescot, Gilles (author): Pitié-Salpêtrière University Hospital

Radovanovic, Dragana (author): University of Zurich

Sendón, Jose Lopez (author): University Hospital La Paz

Tousek, Petr (author): Charles University in Prague

Weidinger, Franz (author): Hospital Rudolfstiftung

Weston, Clive F.M. (author): Swansea University

Zaman, Azfar (author): Freeman Hospital

Andell, Pontus (author): Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital

Li, Jin (author): University of Zurich

Wouter Jukema, J. (author): Leiden University Medical Centre

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(creator_code:org_t)

2016-03-02
2016
English 15 s.
In: European Heart Journal - Cardiovascular Pharmacotherapy. - : Oxford University Press (OUP). - 2055-6837 .- 2055-6845. ; 2:4, s. 229-243

Related links:: http://dx.doi.org/10...; show more...; https://academic.oup...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Aims Non-ST-elevation acute coronary syndrome (NSTE-ACS) is present in about 60-70% of patients admitted with acute coronary syndromes in clinical practice. This study provides a 'real-life' overview of NSTE-ACS patient characteristics, dual antiplatelet therapy clinical practice, and outcomes at both the time of discharge from hospital and up to 1-year post-discharge. Methods and results A total of 10 registries (documenting 84 054 NSTE-ACS patients) provided data in a systematic manner on patient characteristics and outcomes for NSTE-ACS in general, and 6 of these (with 52 173 NSTE-ACS patients) also provided more specific data according to P2Y12 receptor inhibitor used. Unadjusted analyses were performed at the study level, and no formal meta-Analysis was performed due to large heterogeneity between studies in the settings, patient characteristics, and outcome definitions. All-cause death rates across registries ranged from 0.76 to 4.79% in-hospital, from 1.61 to 6.65% at 30 days, from 3.66 to 7.16% at 180 days, and from 3.14 to 9.73% at 1 year. Major bleeding events were reported in up to 2.77% of patients while in hospital (in seven registries), up to 1.08% at 30 days (data from one registry only), and 2.06% at 1 year (one registry). Conclusions There were substantial differences in the use of and patient selection for clopidogrel, prasugrel, and ticagrelor, which were associated with differences in short-And long-Term ischaemic and bleeding events. In future registries, data collection should be performed in a more standardized way with respect to endpoints, definitions, and time points.

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

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P2Y12 receptor inhibitors in patients with non-STelevation acute coronary syndrome in the real world : Use, patient selection, and outcomes from contemporary European registries

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