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FältnamnIndikatorerMetadata
00038765naa a2203205 4500
001oai:DiVA.org:uu-336827
003SwePub
008171220s2017 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:136800324
009oai:lup.lub.lu.se:1878a177-6141-4c4d-bcc7-2ba5507e9a6a
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3368272 URI
024a https://doi.org/10.1371/journal.pmed.10023832 DOI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1368003242 URI
024a https://lup.lub.lu.se/record/1878a177-6141-4c4d-bcc7-2ba5507e9a6a2 URI
040 a (SwePub)uud (SwePub)kid (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Wheeler, Eleanoru Wellcome Trust Sanger Inst, Dept Human Genet, Genome Campus, Cambridge, England.,Wellcome Trust Sanger Institute4 aut
2451 0a Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations :b A transethnic genome-wide meta-analysis
264 c 2017-09-12
264 1b PUBLIC LIBRARY SCIENCE,c 2017
338 a electronic2 rdacarrier
520 a Background: Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and assess glycemic control in patients with diabetes. Previous genome-wide association studies (GWAS) have identified 18 HbA1c-associated genetic variants. These variants proved to be classifiable by their likely biological action as erythrocytic (also associated with erythrocyte traits) or glycemic (associated with other glucose-related traits). In this study, we tested the hypotheses that, in a very large scale GWAS, we would identify more genetic variants associated with HbA1c and that HbA1c variants implicated in erythrocytic biology would affect the diagnostic accuracy of HbA1c. We therefore expanded the number of HbA1c-associated loci and tested the effect of genetic risk-scores comprised of erythrocytic or glycemic variants on incident diabetes prediction and on prevalent diabetes screening performance. Throughout this multiancestry study, we kept a focus on interancestry differences in HbA1c genetics performance that might influence race-ancestry differences in health outcomes.Methods & findings: Using genome-wide association meta-analyses in up to 159,940 individuals from 82 cohorts of European, African, East Asian, and South Asian ancestry, we identified 60 common genetic variants associated with HbA1c. We classified variants as implicated in glycemic, erythrocytic, or unclassified biology and tested whether additive genetic scores of erythrocytic variants (GS-E) or glycemic variants (GS-G) were associated with higher T2D incidence in multiethnic longitudinal cohorts (N = 33,241). Nineteen glycemic and 22 erythrocytic variants were associated with HbA1c at genome-wide significance. GS-G was associated with higher T2D risk (incidence OR = 1.05, 95% CI 1.04-1.06, per HbA1c-raising allele, p = 3 x 10-29); whereas GS-E was not (OR = 1.00, 95% CI 0.99-1.01, p = 0.60). In Europeans and Asians, erythrocytic variants in aggregate had only modest effects on the diagnostic accuracy of HbA1c. Yet, in African Americans, the X-linked G6PD G202A variant (T-allele frequency 11%) was associated with an absolute decrease in HbA1c of 0.81%-units (95% CI 0.66-0.96) per allele in hemizygous men, and 0.68%-units (95% CI 0.38-0.97) in homozygous women. The G6PD variant may cause approximately 2% (N = 0.65 million, 95% CI0.55-0.74) of African American adults with T2Dto remain undiagnosed when screened with HbA1c. Limitations include the smaller sample sizes for non-European ancestries and the inability to classify approximately one-third of the variants. Further studies in large multiethnic cohorts with HbA1c, glycemic, and erythrocytic traits are required to better determine the biological action of the unclassified variants.Conclusions: As G6PD deficiency can be clinically silent until illness strikes, we recommend investigation of the possible benefits of screening for the G6PD genotype along with using HbA1c to diagnose T2D in populations of African ancestry or groups where G6PD deficiency is common. Screening with direct glucose measurements, or genetically-informed HbA1c diagnostic thresholds in people with G6PD deficiency, may be required to avoid missed or delayed diagnoses.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a glycosylated hemoglobin
653 a hemoglobin A1c protein, human
653 a Diabetes Mellitus, Type 2
653 a genetic variation
653 a genetics
653 a genome-wide association study
653 a human
653 a meta analysis
653 a metabolism
653 a phenotype
653 a risk
653 a Genetic Variation
653 a Genome-Wide Association Study
653 a Hemoglobin A, Glycosylated
653 a Humans
653 a Phenotype
653 a Risk
700a Leong, Aaronu Massachusetts Gen Hosp, Div Gen Internal Med, Boston, MA 02114 USA.;Harvard Med Sch, Boston, MA USA.,Harvard Medical School,Massachusetts General Hospital4 aut
700a Liu, Ching-Tiu Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA.,Boston University4 aut
700a Hivert, Marie-Franceu Harvard Pilgrim Hlth Care Inst, Harvard Med Sch, Dept Populat Med, Boston, MA USA.;Massachusetts Gen Hosp, Boston, MA 02114 USA.,Massachusetts General Hospital,Harvard University4 aut
700a Strawbridge, Rona J.u Karolinska Institutet,Karolinska University Hospital4 aut
700a Podmore, Clarau Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.;Lausanne Univ Hosp CHUV, Dept Internal Med, Lausanne, Switzerland.,Lausanne University Hospital,University of Cambridge4 aut
700a Li, Manu Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.;Univ Utah, Div Nephrol, Salt Lake City, UT USA.;Univ Utah, Dept Human Genet, Salt Lake City, UT USA.4 aut
700a Yao, Jieu LABioMed Harbor UCLA Med Ctr, Dept Pediat, Inst Translat Genom & Populat Sci, Torrance, CA USA.4 aut
700a Sim, Xuelingu Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.4 aut
700a Hong, Jaeyoungu Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA.4 aut
700a Chu, Audrey Y.u NHLBI, Framingham Heart Study, Framingham, MA USA.;Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA USA.4 aut
700a Zhang, Weihuau Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Ealing Hosp NHS Trust, Dept Cardiol, Southall, Middx, England.4 aut
700a Wang, Xuu Natl Univ Singapore, Life Sci Inst, Singapore, Singapore.4 aut
700a Chen, Pengu Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.;NIDDK, Phoenix Epidemiol & Clin Res Branch, NIH, Phoenix, AZ USA.;Jilin Univ, Minist Educ, Key Lab Pathobiol, Jilin, Jilin, Peoples R China.;Jilin Univ, Coll Basic Med Sci, Changchun, Jilin, Peoples R China.4 aut
700a Maruthur, Nisa M.u Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.;Johns Hopkins Univ, Sch Med, Div Gen Internal Med, Baltimore, MD USA.;Johns Hopkins Univ, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD USA.;Natl Univ Singapore, Dept Stat & Appl Probabil, Singapore, Singapore.4 aut
700a Porneala, Bianca C.u Massachusetts Gen Hosp, Div Gen Internal Med, Boston, MA 02114 USA.4 aut
700a Sharp, Stephen J.u Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.4 aut
700a Jia, Yuchengu LABioMed Harbor UCLA Med Ctr, Dept Pediat, Inst Translat Genom & Populat Sci, Torrance, CA USA.4 aut
700a Kabagambe, Edmond K.u Karolinska Institutet4 aut
700a Chang, Li-Chingu Acad Sinica, Inst Biomed Sci, Taipei, Taiwan.4 aut
700a Chen, Wei-Minu Univ Virginia, Ctr Publ Hlth Gen, Charlottesville, VA USA.4 aut
700a Elks, Cathy E.u Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.;AstraZeneca, Innovat Med & Early Dev Biotech Unit, Personalised Healthcare & Biomarkers, Cambridge, England.4 aut
700a Evans, Daniel S.u Calif Pacific Med Ctr, Res Inst, San Francisco, CA USA.4 aut
700a Fan, Qiaou Duke NUS Med Sch, Ctr Quantitat Med, Singapore, Singapore.4 aut
700a Giulianini, Francou Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA USA.4 aut
700a Go, Min Jinu Korean Natl Inst Hlth, Ctr Genome Sci, Div Struct & Funct Genom, Osong, Chungchungbuk D, South Korea.4 aut
700a Hottenga, Jouke-Janu Vrije Univ Amsterdam, Biol Psychol, Amsterdam, Netherlands.4 aut
700a Hu, Yaou Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci,Key Lab Nutr & Metab, Shanghai, Peoples R China.4 aut
700a Jackson, Anne U.u Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.4 aut
700a Kanoni, Stavroulau Queen Mary Univ London, William Harvey Res Inst, Barts & London Sch Med & Dent, London, England.4 aut
700a Kim, Young Jinu Korean Natl Inst Hlth, Ctr Genome Sci, Div Struct & Funct Genom, Osong, Chungchungbuk D, South Korea.4 aut
700a Kleber, Marcus E.u Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Mannheim, Germany.4 aut
700a Ladenvall, Claesu Uppsala University,Lund University,Lunds universitet,Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab,Lund Univ, Lund Univ Diabet Ctr, Lund, Sweden.,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)med-cll
700a Lecoeur, Cecileu Univ Lille, CNRS, Inst Pasteur Lille, EGID,UMR 8199, Lille, France.4 aut
700a Lim, Sing-Huiu Singapore Eye Res Inst, Acad Level 6, Discovery Tower, Singapore, Singapore.4 aut
700a Lu, Yingchangu Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Genet Obes & Related Metab Traits Program, New York, NY 10029 USA.4 aut
700a Mahajan, Anubhau Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.4 aut
700a Marzi, Carolau Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Inst Epidemiol 2, Neuherberg, Germany.;German Ctr Diabet Res DZD eV, Partner Munich, Munich, Germany.4 aut
700a Nalls, Mike A.u Data Tecn Int, Glen Echo, MD USA.;NIA, Neurogenet Lab, Bethesda, MD 20892 USA.4 aut
700a Navarro, Pauu Univ Edinburgh, Western Gen Hosp, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland.4 aut
700a Nolte, Ilja M.u Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.4 aut
700a Rose, Lynda M.u Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA USA.4 aut
700a Rybin, Denis V.u Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA.;Boston Univ, Sch Publ Hlth, Data Coordinating Ctr, Boston, MA 02215 USA.4 aut
700a Sanna, Serenau CNR, IRGB, Monserrato, Italy.4 aut
700a Shi, Yuanu Singapore Eye Res Inst, Acad Level 6, Discovery Tower, Singapore, Singapore.4 aut
700a Stram, Daniel O.u Univ Southern Calif, Dept Prevent Med, Los Angeles, CA USA.4 aut
700a Takeuchi, Fumihikou Natl Ctr Global Hlth & Med, Dept Gene Diagnost & Therapeut, Res Inst, Tokyo, Japan.4 aut
700a Tan, Shu Peiu Singapore Eye Res Inst, Acad Level 6, Discovery Tower, Singapore, Singapore.4 aut
700a van der Most, Peter J.u Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.4 aut
700a Van Vliet-Ostaptchouk, Jana V.u Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, Groningen, Netherlands.4 aut
700a Wong, Andrewu MRC Unit Lifelong Hlth & Ageing, London, England.4 aut
700a Yengo, Loicu Univ Lille, CNRS, Inst Pasteur Lille, EGID,UMR 8199, Lille, France.4 aut
700a Zhao, Wantingu Singapore Eye Res Inst, Acad Level 6, Discovery Tower, Singapore, Singapore.4 aut
700a Goel, Anuju Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England.4 aut
700a Martinez Larrad, Maria Teresau Spanish Biomed Res Ctr Diabet & Assoc Metab Disor, Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Madrid, Spain.4 aut
700a Radke, Doertu Univ Med Greifswald, Inst Community Med, Greifswald, Germany.4 aut
700a Salo, Perttuu Natl Inst Hlth & Welf THL, Helsinki, Finland.;Univ Helsinki, Inst Mol Med, Finland FIMM & Diabet & Obes Res Program, Helsinki, Finland.4 aut
700a Tanaka, Toshikou NIA, Translat Gerontol Branch, Baltimore, MD 21224 USA.4 aut
700a van Iperen, Erik P. A.u Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol Biostat & Bioinformat, Amsterdam, Netherlands.;Netherlands Heart Inst, Durrer Ctr Cardiogenet Res, ICIN, Utrecht, Netherlands.4 aut
700a Abecasis, Goncalou Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.4 aut
700a Afaq, Saimau Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.4 aut
700a Alizadeh, Behrooz Z.u Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.4 aut
700a Bertoni, Alain G.u Wake Forest Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC USA.4 aut
700a Bonnefond, Ameliau Univ Lille, CNRS, Inst Pasteur Lille, EGID,UMR 8199, Lille, France.4 aut
700a Boettcher, Yvonneu Univ Leipzig, Integrated Res & Treatment IFB Ctr Adipos Dis, Leipzig, Germany.4 aut
700a Bottinger, Erwin P.u Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.4 aut
700a Campbell, Harryu Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland.4 aut
700a Carlson, Olga D.u NIA, Clin Invest Lab, Baltimore, MD 21224 USA.4 aut
700a Chen, Chien-Hsiunu Acad Sinica, Inst Biomed Sci, Taipei, Taiwan.;China Med Univ, Sch Chinese Med, Taichung, Taiwan.4 aut
700a Cho, Yoon Shinu Korean Natl Inst Hlth, Ctr Genome Sci, Div Struct & Funct Genom, Osong, Chungchungbuk D, South Korea.;Hallym Univ, Dept Biomed Sci, Chunchon, Gangwon Do, South Korea.4 aut
700a Garvey, W. Timothyu Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA.;Univ Alabama Birmingham, Birmingham Vet Affairs Med Ctr, Birmingham, AL USA.4 aut
700a Gieger, Christianu Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Inst Epidemiol 2, Neuherberg, Germany.4 aut
700a Goodarzi, Mark O.u Cedars Sinai Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Los Angeles, CA 90048 USA.4 aut
700a Grallert, Haraldu Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Inst Epidemiol 2, Neuherberg, Germany.;German Ctr Diabet Res DZD eV, Partner Munich, Munich, Germany.4 aut
700a Hamsten, Andersu Karolinska Institutet4 aut
700a Hartman, Catharina A.u Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.4 aut
700a Herder, Christianu Univ Dusseldorf, German Diabet Ctr, Leibniz Inst Diabet Res Heinrich Heine, Inst Clin Diabetol, Dusseldorf, Germany.;German Ctr Diabet Res DZD, Neuherberg, Germany.4 aut
700a Hsiung, Chao Agnesu Ohio State Univ, Wexner Med Ctr, Dept Internal Med, Div Endocrinol Diabet Metab, Columbus, OH 43210 USA.4 aut
700a Huang, Jieu Boston VA Res Inst Inc, Boston, MA USA.4 aut
700a Igase, Michiyau Ehime Univ, Grad Sch Med, Dept Geriatr Med, Matsuyama, Ehime, Japan.4 aut
700a Isono, Masatou Natl Ctr Global Hlth & Med, Dept Gene Diagnost & Therapeut, Res Inst, Tokyo, Japan.4 aut
700a Katsuya, Tomohirou Osaka Univ, Grad Sch Med, Dept Clin Gene Therapy, Suita, Osaka, Japan.;Osaka Univ, Grad Sch Med, Dept Geriatr Med & Nephrol, Suita, Osaka, Japan.4 aut
700a Khor, Chiea-Chuenu Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore.4 aut
700a Kiess, Wielandu Univ Leipzig, Univ Hosp Children & Adolescents, Dept Womens & Child Hlth, Ctr Pediat Res, Leipzig, Germany.;Univ Leipzig, LIFE Leipzig Res Ctr Civilizat Dis, LIFE Child, Leipzig, Germany.4 aut
700a Kohara, Katsuhikou Ehime Univ, Fac Collaborat Reg Innovat, Matsuyama, Ehime, Japan.4 aut
700a Kovacs, Peteru Univ Leipzig, Integrated Res & Treatment IFB Ctr Adipos Dis, Leipzig, Germany.4 aut
700a Lee, Juyoungu Korean Natl Inst Hlth, Ctr Genome Sci, Div Struct & Funct Genom, Osong, Chungchungbuk D, South Korea.4 aut
700a Lee, Wen-Janeu Taichung Vet Gen Hosp, Dept Med Res, Taichung, Taiwan.4 aut
700a Lehne, Benjaminu Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.4 aut
700a Li, Huaixingu Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci,Key Lab Nutr & Metab, Shanghai, Peoples R China.4 aut
700a Liu, Jianjunu Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.;Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore.4 aut
700a Lobbens, Stephaneu Univ Lille, CNRS, Inst Pasteur Lille, EGID,UMR 8199, Lille, France.4 aut
700a Luang, Jian'anu Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.4 aut
700a Lyssenko, Valeriyau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-vly
700a Meitinger, Thomasu Tech Univ Munich, Inst Human Genet, Munich, Germany.;Helmholtz Zentrum Munchen, Inst Human Genet, Neuherberg, Germany.;Munich Cluster Syst Neurol SyNergy, Munich, Germany.;Singapore Natl Eye Ctr, Singapore, Singapore.4 aut
700a Miki, Tetsurou Ehime Univ, Grad Sch Med, Dept Geriatr Med, Matsuyama, Ehime, Japan.4 aut
700a Miljkovic, Ivau Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA.4 aut
700a Moon, Sanghoonu Korean Natl Inst Hlth, Ctr Genome Sci, Div Struct & Funct Genom, Osong, Chungchungbuk D, South Korea.4 aut
700a Mulas, Antonellau CNR, IRGB, Monserrato, Italy.4 aut
700a Mueller, Gabrieleu Univ Hosp & Med Fac Carl Gustav Carus, Ctr Evidence Based Healthcare, Dresden, Germany.4 aut
700a Mueller-Nurasyid, Martinau German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Genet Epidemiol, Neuherberg, Germany.;Ludwig Maximilians Univ Munchen, Univ Hosp Grosshadern, Dept Med 1, Munich, Germany.;DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany.;King Abdulaziz Univ, Fand Med Res Ctr, Saudi Diabet Res Grp, Jeddah, Saudi Arabia.4 aut
700a Nagaraja, Ramaiahu NIA, Genet Lab, Baltimore, MD 21224 USA.4 aut
700a Nauck, Matthiasu Univ Med Greifswald, Inst Clin Chem, Greifswald, Germany.;Univ Med Greifswald, Lab Med, Greifswald, Germany.4 aut
700a Pankow, James S.u Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN USA.4 aut
700a Polasek, Ozrenu Univ Split, Split, Croatia.;Univ Edinburgh, Ctr Populat Hlth Sci, Edinburgh, Midlothian, Scotland.4 aut
700a Prokopenko, Ingau Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Radcliffe Dept Med, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Imperial Coll London, Sch Publ Hlth, Dept Genom Common Dis, London, England.4 aut
700a Ramos, Paula S.u Med Univ South Carolina, Dept Med, Charleston, SC USA.4 aut
700a Rasmussen-Torvik, Laurau Northwestern Univ Feinberg Sch Med, Dept Prevent Med, Chicago, IL USA.4 aut
700a Rathmann, Wolfgangu German Ctr Diabet Res DZD, Neuherberg, Germany.4 aut
700a Rich, Stephen S.u Univ Virginia, Sch Med, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA.4 aut
700a Robertson, Neil R.u Univ Oxford, Radcliffe Dept Med, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Univ Oxford, Nuffield Dept Med, Wellcome Trust Ctr Human Genet, Oxford, England.4 aut
700a Roden, Michaelu Univ Dusseldorf, German Diabet Ctr, Leibniz Inst Diabet Res Heinrich Heine, Inst Clin Diabetol, Dusseldorf, Germany.;German Ctr Diabet Res DZD, Neuherberg, Germany.;Univ Hosp Dusseldorf, Dept Endocrinol & Diabetol, Dusseldorf, Germany.4 aut
700a Roussel, Ronanu Ctr Rech Cordelier, INSERM, UMR S 1138, Paris, France.;Univ Paris Diderot, Sorbonne Paris Cite, UFR Med, Paris, France.;Hop Xavier Bichat, AP HP, DHU FIRE, Dept Diabetol Endocrinol & Nutr, Paris, France.4 aut
700a Rudan, Igoru Univ Edinburgh, Edinburgh, Midlothian, Scotland.4 aut
700a Scott, Robert A.u Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.4 aut
700a Scott, William R.u Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Ealing Hosp NHS Trust, Dept Cardiol, Southall, Middx, England.4 aut
700a Sennblad, Bengtu Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden.;Karolinska Univ Jukhuset, Ctr Mol Med, Solna, Sweden.;Karolinska Inst, Sci life Lab, Solna, Sweden.4 aut
700a Siscovick, David S.u New York Acad Med, New York, NY USA.4 aut
700a Strauch, Konstantinu German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Genet Epidemiol, Neuherberg, Germany.;Ludwig Maximilians Univ Munchen, Inst Med Informat Biometry & Epidemiol, Munich, Germany.4 aut
700a Sun, Liangu Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci,Key Lab Nutr & Metab, Shanghai, Peoples R China.4 aut
700a Swertz, Morrisu Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands.4 aut
700a Tajuddin, Salman M.u NIA, Hlth Dispar Unit, NIH, Baltimore, MD 21224 USA.4 aut
700a Taylor, Kent D.u LABioMed Harbor UCLA Med Ctr, Dept Pediat, Inst Translat Genom & Populat Sci, Torrance, CA USA.4 aut
700a Teo, Yik-Yingu Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.;Natl Univ Singapore, Life Sci Inst, Singapore, Singapore.;Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore.;Natl Univ Singapore, NUS Grad Sch Integrat Sci & Engn, Singapore, Singapore.;Singapore Natl Eye Ctr, Singapore, Singapore.4 aut
700a Tham, Yih Chungu Singapore Eye Res Inst, Acad Level 6, Discovery Tower, Singapore, Singapore.4 aut
700a Toenjes, Ankeu Univ Leipzig, Dept Med, Leipzig, Germany.4 aut
700a Wareham, Nicholas J.u Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.4 aut
700a Willemsen, Gonnekeu Vrije Univ Amsterdam, Biol Psychol, Amsterdam, Netherlands.4 aut
700a Wilsgaard, Tomu Univ Tromso, Fac Hlth Sci, Dept Community Med, Tromso, Norway.4 aut
700a Hingorani, Aroon D.u UCL, Inst Cardiovasc Sci, London, England.4 aut
700a Egan, Josephineu NIA, Clin Invest Lab, Baltimore, MD 21224 USA.4 aut
700a Ferrucci, Luigiu NIA, Clin Invest Lab, Baltimore, MD 21224 USA.4 aut
700a Hovingh, G. Keesu Acad Med Ctr, Dept Vasc Med, Amsterdam, Netherlands.4 aut
700a Jula, Anttiu Natl Inst Hlth & Welf THL, Helsinki, Finland.4 aut
700a Kivimaki, Mikau UCL, Dept Epidemiol & Publ Hlth, London, England.4 aut
700a Kumari, Meenau UCL, Dept Epidemiol & Publ Hlth, London, England.;Univ Essex, Inst Social & Econ Res, Colchester, Essex, England.4 aut
700a Njolstad, Ingeru Univ Tromso, Fac Hlth Sci, Dept Community Med, Tromso, Norway.4 aut
700a Palmer, Colin N. A.u Med Res Inst, Ninewells Hosp & Med Sch, Pat Macpherson Ctr Pharmacogenet & Pharmacogenom, Dundee, Scotland.4 aut
700a Serrano Rios, Manuelu Spanish Biomed Res Ctr Diabet & Assoc Metab Disor, Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Madrid, Spain.4 aut
700a Stumvoll, Michaelu Univ Leipzig, Dept Med, Leipzig, Germany.4 aut
700a Watkins, Hughu Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England.4 aut
700a Aung, Tinu Singapore Eye Res Inst, Acad Level 6, Discovery Tower, Singapore, Singapore.;Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore, Singapore.;Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore, Singapore.4 aut
700a Blueher, Matthiasu Univ Leipzig, Dept Med, Leipzig, Germany.4 aut
700a Boehnke, Michaelu Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.4 aut
700a Boomsma, Dorret I.u Vrije Univ Amsterdam, Biol Psychol, Amsterdam, Netherlands.4 aut
700a Bornstein, Stefan R.u Univ Dresden, Med Fac Carl Gustav Carus, Dept Med 3, Dresden, Germany.4 aut
700a Chambers, John C.u Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Ealing Hosp NHS Trust, Dept Cardiol, Southall, Middx, England.;Imperial Coll Healthcare NHS Trust, London, England.4 aut
700a Chasman, Daniel I.u Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA USA.;Brigham & Womens Hosp, Div Genet, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA USA.;Broad Inst MIT & Harvard, Cambridge, MA USA.4 aut
700a Chen, Yii-Der Idau LABioMed Harbor UCLA Med Ctr, Dept Pediat, Inst Translat Genom & Populat Sci, Torrance, CA USA.4 aut
700a Chen, Yduan-Tsongu Acad Sinica, Inst Biomed Sci, Taipei, Taiwan.4 aut
700a Cheng, Ching-Yuu Singapore Eye Res Inst, Acad Level 6, Discovery Tower, Singapore, Singapore.;Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore, Singapore.;Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore, Singapore.4 aut
700a Cucca, Francescou CNR, IRGB, Monserrato, Italy.;Univ Sassari, Dipartimento Sci Biomed, Sassari, Italy.4 aut
700a de Geus, Eco J. C.u Vrije Univ Amsterdam, Biol Psychol, Amsterdam, Netherlands.4 aut
700a Deloukas, Panosu Queen Mary Univ London, William Harvey Res Inst, Barts & London Sch Med & Dent, London, England.;King Abdulaziz Univ, Princess Al Jawhara AI Brahim Ctr Excellence Res, Jeddah, Saudi Arabia.4 aut
700a Evans, Michele K.u NIA, Hlth Dispar Unit, NIH, Baltimore, MD 21224 USA.4 aut
700a Fornage, Myriamu Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Div Epidemiol, Brown Fdn Inst Mol Med, Houston, TX 77030 USA.4 aut
700a Friedlander, Yechielu Hebrew Univ Jerusalem, Hadassah Med Ctr, Braun Sch Publ Hlth, Jerusalem, Israel.4 aut
700a Froguel, Philippeu Imperial Coll London, Sch Publ Hlth, Dept Genom Common Dis, London, England.;Lille Univ, CNRS 8199, Lille, France.4 aut
700a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Institute for Molecular Medicine Finland (FIMM)4 aut0 (Swepub:lu)endo-lgr
700a Gross, Myron D.u Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA.4 aut
700a Harris, Tamara B.u NIA, Bethesda, MD 20892 USA.4 aut
700a Hayward, Carolineu Univ Edinburgh, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.4 aut
700a Heng, Chew-Kiatu Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Paediat, Singapore, Singapore.;Natl Univ Hlth Syst, Khoo Teck Puat Natl Univ Childrens Med Inst, Singapore, Singapore.4 aut
700a Ingelsson, Erik,d 1975-u Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA.4 aut0 (Swepub:uu)ering425
700a Kato, Norihirou Natl Ctr Global Hlth & Med, Dept Gene Diagnost & Therapeut, Res Inst, Tokyo, Japan.4 aut
700a Kim, Bong-Jou Korean Natl Inst Hlth, Ctr Genome Sci, Div Struct & Funct Genom, Osong, Chungchungbuk D, South Korea.4 aut
700a Koh, Woon-Puayu Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.;Duke NUS Med Sch Singapore, Singapore, Singapore.4 aut
700a Kooner, Jaspal S.u Ealing Hosp NHS Trust, Dept Cardiol, Southall, Middx, England.;Imperial Coll Healthcare NHS Trust, London, England.;Imperial Coll London, Natl Heart & Lung Inst, Hammersmith Hosp Campus, London, England.4 aut
700a Koerner, Antjeu Univ Leipzig, Univ Hosp Children & Adolescents, Dept Womens & Child Hlth, Ctr Pediat Res, Leipzig, Germany.;Univ Leipzig, LIFE Leipzig Res Ctr Civilizat Dis, LIFE Child, Leipzig, Germany.4 aut
700a Kuh, Dianau MRC Unit Lifelong Hlth & Ageing, London, England.4 aut
700a Kuusisto, Johannau Univ Eastern Finland, Inst Clin Med Internal Med, Kuopio, Finland.;Kuopio Univ Hosp, Kuopio, Finland.4 aut
700a Laakso, Markkuu Univ Eastern Finland, Inst Clin Med Internal Med, Kuopio, Finland.;Kuopio Univ Hosp, Kuopio, Finland.4 aut
700a Lin, Xuu Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci,Key Lab Nutr & Metab, Shanghai, Peoples R China.4 aut
700a Liu, Yongmeiu Wake Forest Univ, Dept Epidemiol & Prevent, Div Publ Hlth Sci, Winston Salem, NC 27109 USA.4 aut
700a Loos, Ruth J. F.u Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Genet Obes & Related Metab Traits Program, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Mindich Child Hlth Dev Inst, New York, NY 10029 USA.4 aut
700a Magnusson, Patrik K. E.u Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.4 aut
700a Maerz, Winfriedu Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Mannheim, Germany.;Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria.;Synlab Serv GmbH, Synlab Acad, Mannheim, Germany.4 aut
700a McCarthy, Mark I.u Univ Oxford, Radcliffe Dept Med, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Univ Oxford, Nuffield Dept Med, Wellcome Trust Ctr Human Genet, Oxford, England.;Oxford Univ Hosp Trust, Oxford NIHR Biomed Res Ctr, Oxford, England.4 aut
700a Oldehinkel, Albertine J.u Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.4 aut
700a Ong, Ken K.u Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.4 aut
700a Pedersen, Nancy L.u Karolinska Institutet4 aut
700a Pereira, Mark A.u Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN USA.4 aut
700a Peters, Annetteu Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Inst Epidemiol 2, Neuherberg, Germany.4 aut
700a Ridker, Paul M.u Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA USA.;Harvard Med Sch, Boston, MA USA.;Brigham & Womens Hosp, Div Cardiovasc Med, 75 Francis St, Boston, MA 02115 USA.4 aut
700a Sabanayagam, Charumathiu Singapore Eye Res Inst, Acad Level 6, Discovery Tower, Singapore, Singapore.;Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore, Singapore.4 aut
700a Sale, Micheleu Univ Virginia, Sch Med, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA.4 aut
700a Saleheen, Danishu Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA.;Ctr Noncommunicable Dis, Karachi, Pakistan.4 aut
700a Saltevo, Juhau Cent Finland, Cent Hosp, Dept Med, Jyvaskyla, Finland.4 aut
700a Schwarz, Peter E. H.u Univ Dresden, Med Fac Carl Gustav Carus, Dept Med 3, Dresden, Germany.4 aut
700a Sheu, Wayne H. H.u Taichung Vet Gen Hosp, Dept Internal Med, Div Endocrine & Metab, Taichung, Taiwan.;Natl Yang Ming Univ, Sch Med, Taipei, Taiwan.;Natl Def Med Ctr, Sch Med, Taipei, Taiwan.4 aut
700a Snieder, Haroldu Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.4 aut
700a Spector, Timothy D.u Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England.4 aut
700a Tabara, Yasuharuu Kyoto Univ, Grad Sch Med, Ctr Genom Med, Kyoto, Japan.4 aut
700a Tuomilehto, Jaakkou Natl Inst Hlth & Welf, Chron Dis Prevent Unit, Helsinki, Finland.;Dasman Diabet Inst, Dasman, Kuwait.;Danube Univ Krems, Ctr Vasc Prevent, Krems, Austria.4 aut
700a van Dam, Rob M.u Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.4 aut
700a Wilson, James G.u Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Jackson, MS 39216 USA.4 aut
700a Wilson, James F.u Univ Edinburgh, Western Gen Hosp, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland.4 aut
700a Wolffenbuttel, Bruce H. R.u Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, Groningen, Netherlands.4 aut
700a Wong, Tien Yinu Singapore Eye Res Inst, Acad Level 6, Discovery Tower, Singapore, Singapore.;Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore, Singapore.;Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore, Singapore.4 aut
700a Wu, Jer-Yuarnu Acad Sinica, Inst Biomed Sci, Taipei, Taiwan.;China Med Univ, Sch Chinese Med, Taichung, Taiwan.4 aut
700a Yuan, Jian-Minu Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA.;Univ Pittsburgh, Inst Canc, Div Canc Control & Populat Sci, Pittsburgh, PA USA.4 aut
700a Zonderman, Alan B.u NIA, Lab Epidemiol & Populat Sci, NIH, Baltimore, MD 21224 USA.4 aut
700a Soranzo, Nicoleu Wellcome Trust Sanger Inst, Dept Human Genet, Genome Campus, Cambridge, England.;Univ Cambridge, Dept Haematol, Cambridge, England.;Univ Cambridge, Natl Inst Hlth Res Blood & Transplant Unit NIHR B, Cambridge, England.4 aut
700a Guo, Xiuqingu LABioMed Harbor UCLA Med Ctr, Dept Pediat, Inst Translat Genom & Populat Sci, Torrance, CA USA.4 aut
700a Roberts, David J.u Univ Oxford, Biomed Res Ctr Oxford Haematol Theme, Headley Way, Oxford, England.;Univ Oxford, John Radcliffe Hosp, Radcliffe Dept Med, Headley Way, Oxford, England.;NHS Blood & Transplant, Oxford, England.4 aut
700a Florez, Jose C.u Harvard Med Sch, Boston, MA USA.;Massachusetts Gen Hosp, Diabet Unit & Ctr Human Genet Res, Boston, MA 02114 USA.;Broad Inst, Programs Metab & Med & Populat Genet, Cambridge, MA USA.4 aut
700a Sladek, Robertu McGill Univ, Dept Med, Montreal, PQ, Canada.4 aut
700a Dupuis, Joseeu Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA.;NHLBI, Framingham Heart Study, Framingham, MA USA.4 aut
700a Morris, Andrew P.u Univ Oxford, Nuffield Dept Med, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England.4 aut
700a Tai, E-Shyongu Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.;Duke NUS Med Sch Singapore, Singapore, Singapore.;Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore.4 aut
700a Selvin, Elizabethu Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.;Johns Hopkins Univ, Sch Med, Div Gen Internal Med, Baltimore, MD USA.;Johns Hopkins Univ, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD USA.;Singapore Natl Eye Ctr, Singapore, Singapore.4 aut
700a Rotter, Jerome I.u LABioMed Harbor UCLA Med Ctr, Dept Pediat, Inst Translat Genom & Populat Sci, Torrance, CA USA.4 aut
700a Langenberg, Claudiau Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.4 aut
700a Barroso, Inesu Wellcome Trust Sanger Inst, Dept Human Genet, Genome Campus, Cambridge, England.;Univ Cambridge, Inst Metab Sci, Cambridge, England.4 aut
700a Meigs, James B.u Massachusetts Gen Hosp, Div Gen Internal Med, Boston, MA 02114 USA.;Harvard Med Sch, Boston, MA USA.;Broad Inst, Programs Metab & Med & Populat Genet, Cambridge, MA USA.,Broad Institute,Harvard University,Massachusetts General Hospital4 aut
710a Wellcome Trust Sanger Inst, Dept Human Genet, Genome Campus, Cambridge, England.b Wellcome Trust Sanger Institute4 org
773t PLoS Medicined : PUBLIC LIBRARY SCIENCEg 14:9q 14:9x 1549-1277x 1549-1676
856u https://doi.org/10.1371/journal.pmed.1002383y Fulltext
856u https://uu.diva-portal.org/smash/get/diva2:1168199/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856u https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1002383&type=printable
856u http://dx.doi.org/10.1371/journal.pmed.1002383x freey FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-336827
8564 8u https://doi.org/10.1371/journal.pmed.1002383
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:136800324
8564 8u https://lup.lub.lu.se/record/1878a177-6141-4c4d-bcc7-2ba5507e9a6a

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