Sökning: (WFRF:(Peltonen Leena)) >
USF1 gene variants ...
USF1 gene variants contribute to metabolic traits in men in a longitudinal 32-year follow-up study
- Artikel/kapitelEngelska2008
Förlag, utgivningsår, omfång ...
-
2007-12-21
-
Springer Science and Business Media LLC,2008
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-106228
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-106228URI
-
https://doi.org/10.1007/s00125-007-0892-9DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
AIMS/HYPOTHESIS: Genetic variants of upstream transcription factor 1 (USF1) have previously been associated with dyslipidaemias in family studies. Our aim was to further address the role of USF1 in metabolic syndrome and cardiovascular traits at the population level in a large Swedish male cohort (n=2,322) with multiple measurements for risk factors during 32 years of follow-up. METHODS: Participants, born in 1920-1924, were examined at 50, 60, 70 and 77 years of age. The follow-up period for cardiovascular events was 1970-2002. We genotyped three haplotype tagging polymorphisms capturing the major allelic variants of USF1. RESULTS: SNP rs2774279 was associated with the metabolic syndrome. The minor allele of rs2774279 was less common among individuals with metabolic syndrome than among healthy controls [p=0.0029 when metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III; p=0.0073 when defined according to the International Diabetes Federation (IDF)]. The minor allele of rs2774279 was also associated with lower BMI, lower fasting glucose values and higher HDL-cholesterol concentrations in longitudinal analyses. With SNP rs2073658, a borderline association with metabolic syndrome was observed (p=0.036, IDF), the minor allele being the risk-increasing allele. The minor allele of rs2073658 also associated with higher total and LDL-cholesterol, apolipoprotein B-100 and lipoprotein(a) concentrations in longitudinal analyses. Importantly, these trends with respect to the allelic variants prevailed throughout the follow-up time of three decades. CONCLUSIONS/INTERPRETATION: Our results suggest that USF1 variants associate with the metabolic syndrome at population level and influence the cardiovascular risk factors throughout adulthood in a consistent, longitudinal manner.
Ämnesord och genrebeteckningar
-
Cardiovascular diseases
-
Epidemiology
-
Genetics
-
Lipids
-
Metabolic syndrome
-
Syndrome X
-
MEDICINE
-
MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Kristiansson, K.
(författare)
-
Zethelius, BjörnUppsala universitet,Geriatrik(Swepub:uu)bjorzeth
(författare)
-
Berne, ChristianUppsala universitet,Institutionen för medicinska vetenskaper,Diabetes och endokrinologi(Swepub:uu)chber255
(författare)
-
Lannfelt, LarsUppsala universitet,Geriatrik(Swepub:uu)lalan021
(författare)
-
Taskinen, M-R.
(författare)
-
Jauhiainen, M.
(författare)
-
Perola, M.
(författare)
-
Peltonen, Leena
(författare)
-
Syvänen, Ann-ChristineUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)anncsyva
(författare)
-
Uppsala universitetGeriatrik
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Diabetologia: Springer Science and Business Media LLC51:3, s. 464-4720012-186X1432-0428
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Auro, K.
-
Kristiansson, K.
-
Zethelius, Björn
-
Berne, Christian
-
Lannfelt, Lars
-
Taskinen, M-R.
-
visa fler...
-
Jauhiainen, M.
-
Perola, M.
-
Peltonen, Leena
-
Syvänen, Ann-Chr ...
-
visa färre...
- Artiklar i publikationen
-
Diabetologia
- Av lärosätet
-
Uppsala universitet