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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03831naa a2200481 4500 | |
| 001 | oai:DiVA.org:uu-106228 | |
| 003 | SwePub | |
| 008 | 090617s2008 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1062282 URI |
| 024 | 7 | a https://doi.org/10.1007/s00125-007-0892-92 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Auro, K.4 aut |
| 245 | 1 0 | a USF1 gene variants contribute to metabolic traits in men in a longitudinal 32-year follow-up study |
| 264 | c 2007-12-21 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2008 |
| 338 | a print2 rdacarrier | |
| 520 | a AIMS/HYPOTHESIS: Genetic variants of upstream transcription factor 1 (USF1) have previously been associated with dyslipidaemias in family studies. Our aim was to further address the role of USF1 in metabolic syndrome and cardiovascular traits at the population level in a large Swedish male cohort (n=2,322) with multiple measurements for risk factors during 32 years of follow-up. METHODS: Participants, born in 1920-1924, were examined at 50, 60, 70 and 77 years of age. The follow-up period for cardiovascular events was 1970-2002. We genotyped three haplotype tagging polymorphisms capturing the major allelic variants of USF1. RESULTS: SNP rs2774279 was associated with the metabolic syndrome. The minor allele of rs2774279 was less common among individuals with metabolic syndrome than among healthy controls [p=0.0029 when metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III; p=0.0073 when defined according to the International Diabetes Federation (IDF)]. The minor allele of rs2774279 was also associated with lower BMI, lower fasting glucose values and higher HDL-cholesterol concentrations in longitudinal analyses. With SNP rs2073658, a borderline association with metabolic syndrome was observed (p=0.036, IDF), the minor allele being the risk-increasing allele. The minor allele of rs2073658 also associated with higher total and LDL-cholesterol, apolipoprotein B-100 and lipoprotein(a) concentrations in longitudinal analyses. Importantly, these trends with respect to the allelic variants prevailed throughout the follow-up time of three decades. CONCLUSIONS/INTERPRETATION: Our results suggest that USF1 variants associate with the metabolic syndrome at population level and influence the cardiovascular risk factors throughout adulthood in a consistent, longitudinal manner. | |
| 653 | a Cardiovascular diseases | |
| 653 | a Epidemiology | |
| 653 | a Genetics | |
| 653 | a Lipids | |
| 653 | a Metabolic syndrome | |
| 653 | a Syndrome X | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Kristiansson, K.4 aut |
| 700 | 1 | a Zethelius, Björnu Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)bjorzeth |
| 700 | 1 | a Berne, Christianu Uppsala universitet,Institutionen för medicinska vetenskaper,Diabetes och endokrinologi4 aut0 (Swepub:uu)chber255 |
| 700 | 1 | a Lannfelt, Larsu Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)lalan021 |
| 700 | 1 | a Taskinen, M-R.4 aut |
| 700 | 1 | a Jauhiainen, M.4 aut |
| 700 | 1 | a Perola, M.4 aut |
| 700 | 1 | a Peltonen, Leena4 aut |
| 700 | 1 | a Syvänen, Ann-Christineu Uppsala universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)anncsyva |
| 710 | 2 | a Uppsala universitetb Geriatrik4 org |
| 773 | 0 | t Diabetologiad : Springer Science and Business Media LLCg 51:3, s. 464-472q 51:3<464-472x 0012-186Xx 1432-0428 |
| 856 | 4 | u https://link.springer.com/content/pdf/10.1007%2Fs00125-007-0892-9.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-106228 |
| 856 | 4 8 | u https://doi.org/10.1007/s00125-007-0892-9 |
Hitta mer i SwePub
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- Auro, K.
- Kristiansson, K.
- Zethelius, Björn
- Berne, Christian
- Lannfelt, Lars
- Taskinen, M-R.
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- Jauhiainen, M.
- Perola, M.
- Peltonen, Leena
- Syvänen, Ann-Chr ...
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- Diabetologia
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- Uppsala universitet
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