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Genome-wide profili...
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Elo, Laura L.Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland; Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland
(författare)
Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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Cell Press,2010
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-63632
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-63632URI
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https://doi.org/10.1016/j.immuni.2010.06.011DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding agencies:European Commission EC-FP7-SYBILLA-201106 EC-FP7-NANOMMUNE-214281 EC-FP7-DIABIMMUNE-202063 CIMO/SitraSigrid Juselius FoundationDepartment of Biotechnology, Government of IndiaTurku University HospitalNote: The Turku Centre for Biotechnology is a joint department of the Turku University and the Åbo Akademi University
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Dissecting the molecular mechanisms by which T helper (Th) cells differentiate to effector Th2 cells is important for understanding the pathogenesis of immune-mediated diseases, such as asthma and allergy. Because the STAT6 transcription factor is an upstream mediator required for interleukin-4 (IL-4)-induced Th2 cell differentiation, its targets include genes important for this process. Using primary human CD4(+) T cells, and by blocking STAT6 with RNAi, we identified a number of direct and indirect targets of STAT6 with ChIP sequencing. The integration of these data sets with detailed kinetics of IL-4-driven transcriptional changes showed that STAT6 was predominantly needed for the activation of transcription leading to the Th2 cell phenotype. This integrated genome-wide data on IL-4- and STAT6-mediated transcription provide a unique resource for studies on Th cell differentiation and, in particular, for designing interventions of human Th2 cell responses.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Järvenpää, HennaTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Turku Graduate School of Biomedical Sciences, Turku, Finland
(författare)
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Tuomela, SoileTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Turku Graduate School of Biomedical Sciences, Turku, Finland
(författare)
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Raghav, SunilTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland
(författare)
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Ahlfors, HelenaTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; The National Graduate School in Informational and Structural Biology, Åbo Akademi University, Turku, Finland
(författare)
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Laurila, KirstiDepartment of Signal Processing, Tampere University of Technology, Tampere, Finland
(författare)
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Gupta, BhawnaTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland
(författare)
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Lund, Riikka J.Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Department of Biological Science, University of Sheffield, Sheffield, United Kingdom
(författare)
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Tahvanainen, JohannaTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Drug Discovery Graduate School, University of Turku, Turku, Finland
(författare)
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Hawkins, R. DavidLudwig Institute for Cancer Research, University of California, San Diego CA, United States
(författare)
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Oresic, Matej,1967-VTT Technical Research Centre of Finland, Espoo, Finland(Swepub:oru)moc
(författare)
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Lähdesmäki, HarriDepartment of Signal Processing, Tampere University of Technology, Tampere, Finland; Department of Information and Computer Science, Helsinki University of Technology, Helsinki, Finland
(författare)
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Rasool, OmidTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland
(författare)
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Rao, Kanury V.Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland
(författare)
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Aittokallio, TeroInternational Centre for Genetic Engineering and Biotechnology, New Delhi, India; Immune Disease Institute, Harvard Medical School, Boston MA, United States
(författare)
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Lahesmaa, RiittaTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Immune Disease Institute, Harvard Medical School, Boston MA, United States
(författare)
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Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland; Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, FinlandTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Turku Graduate School of Biomedical Sciences, Turku, Finland
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Immunity: Cell Press32:6, s. 852-8621074-76131097-4180
Internetlänk
Hitta via bibliotek
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Immunity
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Till lärosätets databas
- Av författaren/redakt...
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Elo, Laura L.
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Järvenpää, Henna
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Tuomela, Soile
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Raghav, Sunil
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Ahlfors, Helena
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Laurila, Kirsti
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visa fler...
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Gupta, Bhawna
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Lund, Riikka J.
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Tahvanainen, Joh ...
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Hawkins, R. Davi ...
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Oresic, Matej, 1 ...
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Lähdesmäki, Harr ...
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Rasool, Omid
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Rao, Kanury V.
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Aittokallio, Ter ...
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Lahesmaa, Riitta
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Cellbiologi
- Artiklar i publikationen
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Immunity
- Av lärosätet
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Örebro universitet