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FältnamnIndikatorerMetadata
00005579naa a2200493 4500
001oai:DiVA.org:oru-63632
003SwePub
008171222s2010 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-636322 URI
0247 a https://doi.org/10.1016/j.immuni.2010.06.0112 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Elo, Laura L.u Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland; Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland4 aut
2451 0a Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming
264 1b Cell Press,c 2010
338 a print2 rdacarrier
500 a Funding agencies:European Commission EC-FP7-SYBILLA-201106 EC-FP7-NANOMMUNE-214281 EC-FP7-DIABIMMUNE-202063 CIMO/SitraSigrid Juselius FoundationDepartment of Biotechnology, Government of IndiaTurku University HospitalNote:  The Turku Centre for Biotechnology is a joint department of the Turku University and the Åbo Akademi University
520 a Dissecting the molecular mechanisms by which T helper (Th) cells differentiate to effector Th2 cells is important for understanding the pathogenesis of immune-mediated diseases, such as asthma and allergy. Because the STAT6 transcription factor is an upstream mediator required for interleukin-4 (IL-4)-induced Th2 cell differentiation, its targets include genes important for this process. Using primary human CD4(+) T cells, and by blocking STAT6 with RNAi, we identified a number of direct and indirect targets of STAT6 with ChIP sequencing. The integration of these data sets with detailed kinetics of IL-4-driven transcriptional changes showed that STAT6 was predominantly needed for the activation of transcription leading to the Th2 cell phenotype. This integrated genome-wide data on IL-4- and STAT6-mediated transcription provide a unique resource for studies on Th cell differentiation and, in particular, for designing interventions of human Th2 cell responses.
650 7a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng
7001 a Järvenpää, Hennau Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Turku Graduate School of Biomedical Sciences, Turku, Finland4 aut
7001 a Tuomela, Soileu Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Turku Graduate School of Biomedical Sciences, Turku, Finland4 aut
7001 a Raghav, Sunilu Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland4 aut
7001 a Ahlfors, Helenau Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; The National Graduate School in Informational and Structural Biology, Åbo Akademi University, Turku, Finland4 aut
7001 a Laurila, Kirstiu Department of Signal Processing, Tampere University of Technology, Tampere, Finland4 aut
7001 a Gupta, Bhawnau Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland4 aut
7001 a Lund, Riikka J.u Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Department of Biological Science, University of Sheffield, Sheffield, United Kingdom4 aut
7001 a Tahvanainen, Johannau Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Drug Discovery Graduate School, University of Turku, Turku, Finland4 aut
7001 a Hawkins, R. Davidu Ludwig Institute for Cancer Research, University of California, San Diego CA, United States4 aut
7001 a Oresic, Matej,d 1967-u VTT Technical Research Centre of Finland, Espoo, Finland4 aut0 (Swepub:oru)moc
7001 a Lähdesmäki, Harriu Department of Signal Processing, Tampere University of Technology, Tampere, Finland; Department of Information and Computer Science, Helsinki University of Technology, Helsinki, Finland4 aut
7001 a Rasool, Omidu Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland4 aut
7001 a Rao, Kanury V.u Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland4 aut
7001 a Aittokallio, Terou International Centre for Genetic Engineering and Biotechnology, New Delhi, India; Immune Disease Institute, Harvard Medical School, Boston MA, United States4 aut
7001 a Lahesmaa, Riittau Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Immune Disease Institute, Harvard Medical School, Boston MA, United States4 aut
7102 a Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland; Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finlandb Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Turku Graduate School of Biomedical Sciences, Turku, Finland4 org
7730 t Immunityd : Cell Pressg 32:6, s. 852-862q 32:6<852-862x 1074-7613x 1097-4180
8564 u https://doi.org/10.1016/j.immuni.2010.06.011y Fulltext
8564 u http://www.cell.com/article/S1074761310002141/pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-63632
8564 8u https://doi.org/10.1016/j.immuni.2010.06.011

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