Search: (WFRF:(Söderberg Olof))
> (2000-2024) >
A randomised feasib...
A randomised feasibility/phase II study (SBG 2004-1) with dose-dense/tailored epirubicin, cyclophoshamide (EC) followed by docetaxel (T) or fixed dosed dose-dense EC/T versus T, doxorubicin and C (TAC) in node-positive breast cancer.
-
- Margolin, Sara (author)
- Karolinska Institutet,Karolinska Institute
-
- Bengtsson, Nils-Olof (author)
- Umeå universitet,Onkologi,Umea University Hospital
-
- Carlsson, Lena (author)
- Department of Oncology, Sundsvall Hospital, Sweden
-
show more...
-
- Edlund, Per (author)
- Department of Oncology, Gävle Hopsital, Sweden
-
- Hellstrøm, Mats (author)
- Department of Oncology, Karolinska Institute and University Hospital, Stockholm, Sweden
-
- Karlsson, Per, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Sahlgrens University Hospital
-
- Lidbrink, Elisabet (author)
- Department of Oncology, Karolinska Institute and University Hospital, Stockholm, Sweden
-
- Linderholm, Barbro, 1959 (author)
- Östergötlands Läns Landsting,Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Onkologiska kliniken US
-
- Lindman, Henrik (author)
- Uppsala universitet,Enheten för onkologi,University Uppsala Hospital
-
- Malmström, Per (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,University Lund Hospital
-
- Pettersson Skøld, Dagny (author)
- Department of Oncology, Karolinska Institute and University Hospital, Stockholm, Sweden
-
- Søderberg, Martin (author)
- Department of Oncology, Malmø University Hospital, Sweden
-
- Villman, Kenneth (author)
- Department of Oncology, Örebro University Hospital, Sweden
-
- Bergh, Jonas (author)
- Karolinska Institutet,Karolinska Institute
-
show less...
-
(creator_code:org_t)
- Informa Healthcare, 2011
- 2011
- English.
-
In: Acta Oncologica. - : Informa Healthcare. - 0284-186X .- 1651-226X. ; 50:1, s. 35-41
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
https://lup.lub.lu.s...
-
https://gup.ub.gu.se...
-
https://urn.kb.se/re...
-
http://kipublication...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- The aim of the study was to evaluate the feasibility of tailored and dose-dense epirubicin and cyclophosphamide followed by docetaxel as adjuvant breast cancer therapy. Material and methods. Patients with node-positive breast cancer received either four cycles of biweekly and tailored EC (epirubicin 38-60-75-90-105-120 mg/m(2), cyclophosphamide 450-600-900-1200 mg/m(2)) followed by four cycles of docetaxel (60-75-85-100 mg/m(2)) (arm A) or the same regimen with fixed doses (E(90)C(600) + 4 → T(75) + 4) (arm B) or docetaxel, doxorubicin and cyclophosphamide (T(75)A(50)C(500)) every three weeks for six cycles (arm C). All patients received G-CSF support and prophylactic ciprofloxacin. Results. One-hundred and twenty-four patients were randomised in the study. In the A, B and C arm, 17% 19% and 3% of the patients had one or more cycles delayed due to side-effects whereas 24%, 5% and 15% experienced a grade 3 infection or febrile neutropenia. After the introduction of an extra week between the EC and T parts in the A and B arms, grade 3 hand-foot-skin reactions were reduced from 5 to 0.2%. Twenty-nine percent (A and B) and 20% (C) of the patients were hospitalised due to side-effects. Discussion. Dose-dense and tailored EC/T can be given with manageable toxicity and is after adjustment presently studied in the phase III Panther trial.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- onkologi
- Oncology
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Margolin, Sara
-
Bengtsson, Nils- ...
-
Carlsson, Lena
-
Edlund, Per
-
Hellstrøm, Mats
-
Karlsson, Per, 1 ...
-
show more...
-
Lidbrink, Elisab ...
-
Linderholm, Barb ...
-
Lindman, Henrik
-
Malmström, Per
-
Pettersson Skøld ...
-
Søderberg, Marti ...
-
Villman, Kenneth
-
Bergh, Jonas
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Acta Oncologica
- By the university
-
Umeå University
-
Lund University
-
University of Gothenburg
-
Uppsala University
-
Karolinska Institutet
-
Linköping University