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Natriuretic Peptide...
Natriuretic Peptides and Risk of Type 2 Diabetes : Results From the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) Consortium
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- Sujana, Chaterina (author)
- Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute for Medical Information Processing, Biometry, Epidemiology (IBE), Pettenkofer School of Public Health, Ludwig-Maximilians-Universität, Munich, Germany; German Center for Diabetes Research (DZD), Partner Munich-Neuherberg, Germany
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- Salomaa, Veikko (author)
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
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- Kee, Frank (author)
- Centre for Public Health, Queens University of Belfast, Northern Ireland, Belfast, United Kingdom
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- Costanzo, Simona (author)
- Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Isernia, Italy
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- Söderberg, Stefan (author)
- Umeå universitet,Avdelningen för medicin
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- Jordan, Jens (author)
- Institute of Aerospace Medicine, German Aerospace Center (DLR) and University of Cologne, Cologne, Germany
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- Jousilahti, Pekka (author)
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
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- Neville, Charlotte (author)
- Centre for Public Health, Queens University of Belfast, Northern Ireland, Belfast, United Kingdom
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- Iacoviello, Licia (author)
- Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Isernia, Italy; Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy
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- Oskarsson, Viktor (author)
- Umeå universitet,Avdelningen för medicin
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- Westermann, Dirk (author)
- Department for General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany
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- Koenig, Wolfgang (author)
- Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany; German Centre for Cardiovascular Research (DZHK e.V.), partner site Munich Heart Alliance, Munich, Germany
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- Kuulasmaa, Kari (author)
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
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- Reinikainen, Jaakko (author)
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
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- Blankenberg, Stefan (author)
- Department for General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK e.V.), partner site Hamburg, Lübeck, Kiel, Hamburg, Germany
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- Zeller, Tanja (author)
- Department for General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK e.V.), partner site Hamburg, Lübeck, Kiel, Hamburg, Germany
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- Herder, Christian (author)
- Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany; Division of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany; German Center for Diabetes Research (DZD), Partner Düsseldorf, Germany
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- Mansmann, Ulrich (author)
- Institute for Medical Information Processing, Biometry, Epidemiology (IBE), Pettenkofer School of Public Health, Ludwig-Maximilians-Universität, Munich, Germany
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- Peters, Annette (author)
- Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD), Partner Munich-Neuherberg, Germany; German Centre for Cardiovascular Research (DZHK e.V.), partner site Munich Heart Alliance, Munich, Germany
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- Thorand, Barbara (author)
- Institute of Epidemiology, Helmholtz Zentrum Munchen - German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD), Partner Munich-Neuherberg, Munich-Neuherberg, Germany
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(creator_code:org_t)
- 2021-09-14
- 2021
- English.
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In: Diabetes Care. - : American Diabetes Association (ADA). - 0149-5992 .- 1935-5548. ; 44:11, s. 2527-2535
- Related links:
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https://diabetesjour...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
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- OBJECTIVE: Natriuretic peptide (NP) concentrations are increased in cardiovascular diseases (CVDs) but are associated with a lower diabetes risk. We investigated associations of N-terminal pro-B-type NP (NT-proBNP) and midregional proatrial NP (MR-proANP) with incident type 2 diabetes stratified by the presence of CVD.RESEARCH DESIGN AND METHODS: Based on the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) Consortium, we included 45,477 participants with NT-proBNP measurements (1,707 developed type 2 diabetes over 6.5 years of median follow-up; among these, 209 had CVD at baseline) and 11,537 participants with MR-proANP measurements (857 developed type 2 diabetes over 13.8 years of median follow-up; among these, 106 had CVD at baseline). The associations were estimated using multivariable Cox regression models.RESULTS: Both NPs were inversely associated with incident type 2 diabetes (hazard ratios [95% CI] per 1-SD increase of log NP: 0.84 [0.79; 0.89] for NT-proBNP and 0.77 [0.71; 0.83] for MR-proANP). The inverse association between NT-proBNP and type 2 diabetes was significant in individuals without CVD but not in individuals with CVD (0.81 [0.76; 0.86] vs. 1.04 [0.90; 1.19]; P multiplicative interaction = 0.001). There was no significant difference in the association of MR-proANP with type 2 diabetes between individuals without and with CVD (0.75 [0.69; 0.82] vs. 0.81 [0.66; 0.99]; P multiplicative interaction = 0.236).CONCLUSIONS: NT-proBNP and MR-proANP are inversely associated with incident type 2 diabetes. However, the inverse association of NT-proBNP seems to be modified by the presence of CVD. Further investigations are warranted to confirm our findings and to investigate the underlying mechanisms.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Sujana, Chaterin ...
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Salomaa, Veikko
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Kee, Frank
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Costanzo, Simona
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Söderberg, Stefa ...
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Jordan, Jens
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Jousilahti, Pekk ...
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Neville, Charlot ...
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Iacoviello, Lici ...
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Oskarsson, Vikto ...
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Westermann, Dirk
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Koenig, Wolfgang
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Kuulasmaa, Kari
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Reinikainen, Jaa ...
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Blankenberg, Ste ...
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Zeller, Tanja
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Herder, Christia ...
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Mansmann, Ulrich
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Peters, Annette
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Thorand, Barbara
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Diabetes Care
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Umeå University