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Circulating prolact...
Circulating prolactin and breast cancer risk among pre- and postmenopausal women in the EPIC cohort
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Tikk, Kaja (author)
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Sookthai, Disorn (author)
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Johnson, Theron (author)
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Rinaldi, Sabina (author)
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Romieu, Isabelle (author)
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Tjønneland, Anne (author)
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Olsen, Anja (author)
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Overvad, Kim (author)
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Clavel-Chapelon, Francoise (author)
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Baglietto, Laura (author)
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Boeing, Heiner (author)
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Trichopoulou, Antonia (author)
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Lagiou, Pagona (author)
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Trichopoulos, Dimitrios (author)
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Palli, Domenico (author)
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Pala, V (author)
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Tumino, Rosario (author)
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Rosso, S (author)
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Panico, Salvatore (author)
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Agudo, A (author)
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Menéndez, Virginia (author)
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Sánchez, Maria-Jose (author)
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Amiano, Pilar (author)
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Castaño, J M Huerta (author)
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Ardanaz, Eva (author)
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Bas Bueno-de-Mesquita, H (author)
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Monninkhof, Evelyn (author)
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Onland-Moret, C (author)
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- Andersson, Anne (author)
- Umeå universitet,Onkologi
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- Sund, Malin, 1972- (author)
- Umeå universitet,Kirurgi
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Khaw, Kay-Tee (author)
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Key, Timothy J (author)
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Travis, Ruth C (author)
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Gunter, Marc J (author)
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Riboli, Elio (author)
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Dossus, Laure (author)
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Kaaks, Rudolf (author)
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(creator_code:org_t)
- Oxford University Press, 2014
- 2014
- English.
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In: Annals of Oncology. - : Oxford University Press. - 0923-7534 .- 1569-8041. ; 25:7, s. 1422-1428
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
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- BACKGROUND: Experimental and epidemiological evidence suggests that prolactin might play a role in the etiology of breast cancer. We analyzed the relationship of pre-diagnostic circulating prolactin levels with the risk of breast cancer by menopausal status, use of postmenopausal hormone replacement therapy (HRT) at blood donation, and by estrogen and progesterone receptor-status of the breast tumors. METHODS: Conditional logistic regression was used to analyze the data from a case-control study nested within the prospective European EPIC cohort, including 2250 invasive breast cancer and their matched control subjects. RESULTS: Statistically significant heterogeneity in the association of prolactin levels with breast cancer risk between women who were either pre- or postmenopausal at the time of blood donation was observed (Phet=0.04). Higher serum levels of prolactin were associated with significant increase in risk of breast cancer among postmenopausal women (ORQ4-Q1=1.29 [95%CI 1.05-1.58], Ptrend=0.09); however this increase in risk seemed to be confined to women who used postmenopausal HRT at blood donation (ORQ4-Q1=1.45 [95%CI 1.08-1.95], Ptrend=0.01), whereas no statistically significant association was found for the non-users of HRT (ORQ4-Q1 =1.11 [95%CI 0.83-1.49], Ptrend=0.80) (Phet=0.08). Among premenopausal women, a statistically non-significant inverse association was observed (ORQ4-Q1 =0.70 [95%CI 0.48-1.03], Ptrend=0.16). There was no heterogeneity in the prolactin-breast cancer association by hormone receptor status of the tumor. CONCLUSION: Our study indicates that higher circulating levels of prolactin among the postmenopausal HRT users at baseline may be associated with increased breast cancer risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- breast cancer. prolactin levels. hormone replacement therapy. estrogen receptor. progesterone receptor. prospective cohort
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Tikk, Kaja
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Sookthai, Disorn
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Johnson, Theron
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Rinaldi, Sabina
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Romieu, Isabelle
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Tjønneland, Anne
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show more...
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Olsen, Anja
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Overvad, Kim
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Clavel-Chapelon, ...
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Baglietto, Laura
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Boeing, Heiner
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Trichopoulou, An ...
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Lagiou, Pagona
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Trichopoulos, Di ...
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Palli, Domenico
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Pala, V
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Tumino, Rosario
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Rosso, S
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Panico, Salvator ...
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Agudo, A
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Menéndez, Virgin ...
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Sánchez, Maria-J ...
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Amiano, Pilar
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Castaño, J M Hue ...
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Ardanaz, Eva
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Bas Bueno-de-Mes ...
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Monninkhof, Evel ...
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Onland-Moret, C
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Andersson, Anne
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Sund, Malin, 197 ...
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Weiderpass, Elis ...
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Khaw, Kay-Tee
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Key, Timothy J
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Travis, Ruth C
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Gunter, Marc J
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Riboli, Elio
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Dossus, Laure
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Kaaks, Rudolf
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Annals of Oncolo ...
- By the university
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Umeå University
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Karolinska Institutet