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Applying polygenic ...
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
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de Jong, S (author)
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- Diniz, MJA (author)
- Karolinska Institutet
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Saloma, A (author)
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show more...
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Gadelha, A (author)
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- Landén, Mikael, 1966 (author)
- Gothenburg University,Göteborgs universitet,Karolinska Institutet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Ota, VK (author)
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Noto, C (author)
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Curtis, C (author)
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Newhouse, SJ (author)
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Patel, H (author)
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Hall, LS (author)
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O'Reilly, PF (author)
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Belangero, SI (author)
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- Adolfsson, Rolf (author)
- Umeå universitet,Psykiatri
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Breen, G (author)
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Wray, NR (author)
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Ripke, S (author)
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- Mattheisen, M (author)
- Karolinska Institutet
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Trzaskowski, M (author)
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Byrne, EM (author)
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- Abdellaoui, A (author)
- Karolinska Institutet
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Adams, MJ (author)
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Agerbo, E (author)
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Air, TM (author)
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Andlauer, TFM (author)
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Bacanu, SA (author)
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Baekvad-Hansen, M (author)
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Beekman, ATF (author)
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Bigdeli, TB (author)
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Binder, EB (author)
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Blackwood, DHR (author)
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- Bryois, J (author)
- Karolinska Institutet
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Buttenschon, HN (author)
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Bybjerg-Grauholm, J (author)
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Cai, N (author)
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Castelao, E (author)
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Christensen, JH (author)
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Clarke, TK (author)
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Coleman, JRI (author)
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Colodro-Conde, L (author)
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Couvy-Duchesne, B (author)
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Craddock, N (author)
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Crawford, GE (author)
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Davies, G (author)
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Deary, IJ (author)
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Degenhardt, F (author)
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Derks, EM (author)
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Direk, N (author)
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Dolan, CV (author)
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Dunn, EC (author)
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Eley, TC (author)
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Escott-Price, V (author)
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Kiadeh, FFH (author)
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Finucane, HK (author)
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Forstner, AJ (author)
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Frank, J (author)
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Gaspar, HA (author)
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Gill, M (author)
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Goes, FS (author)
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Gordon, SD (author)
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Grove, J (author)
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Hansen, CS (author)
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Hansen, TF (author)
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Herms, S (author)
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Hickie, IB (author)
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Hoffmann, P (author)
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Homuth, G (author)
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Horn, C (author)
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Hottenga, JJ (author)
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Hougaard, DM (author)
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Ising, M (author)
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Jansen, R (author)
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Jones, I (author)
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Jones, LA (author)
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Jorgenson, E (author)
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Knowles, JA (author)
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Kohane, IS (author)
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Kraft, J (author)
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Kretzschmar, WW (author)
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Krogh, J (author)
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Kutalik, Z (author)
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Li, YH (author)
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Lind, PA (author)
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MacIntyre, DJ (author)
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MacKinnon, DF (author)
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Maier, RM (author)
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Maier, W (author)
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Marchini, J (author)
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Mbarek, H (author)
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McGrath, P (author)
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McGuffin, P (author)
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Medland, SE (author)
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Mehta, D (author)
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Middeldorp, CM (author)
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Mihailov, E (author)
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Milaneschi, Y (author)
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Milani, L (author)
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Mondimore, FM (author)
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Montgomery, GW (author)
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Mostafavi, S (author)
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Mullins, N (author)
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Nauck, M (author)
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Ng, B (author)
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Nivard, MG (author)
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Nyholt, DR (author)
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Oskarsson, H (author)
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Owen, MJ (author)
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Painter, JN (author)
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Pedersen, CB (author)
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Pedersen, MG (author)
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- Peterson, RE (author)
- Karolinska Institutet
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- Pettersson, E (author)
- Karolinska Institutet
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Peyrot, WJ (author)
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Pistis, G (author)
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Posthuma, D (author)
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Quiroz, JA (author)
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Qvist, P (author)
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Rice, JP (author)
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Riley, BP (author)
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Rivera, M (author)
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Mirza, SS (author)
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Schoevers, R (author)
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Schulte, EC (author)
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Shen, L (author)
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Shyn, SI (author)
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- Sigurdsson, E (author)
- Karolinska Institutet
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Sinnamon, GCB (author)
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Smit, JH (author)
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Smith, DJ (author)
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Stefansson, H (author)
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Steinberg, S (author)
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Streit, F (author)
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Strohmaier, J (author)
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Tansey, KE (author)
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Teismann, H (author)
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Teumer, A (author)
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Thompson, W (author)
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Thomson, PA (author)
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Thorgeirsson, TE (author)
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Traylor, M (author)
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Treutlein, J (author)
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Trubetskoy, V (author)
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Uitterlinden, AG (author)
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Umbricht, D (author)
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Van der Auwera, S (author)
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van Hemert, AM (author)
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- Viktorin, A (author)
- Karolinska Institutet
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Visscher, PM (author)
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Wang, YP (author)
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Webb, BT (author)
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Weinsheimer, SM (author)
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Wellmann, J (author)
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Willemsen, G (author)
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Witt, SH (author)
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Wu, Y (author)
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Xi, HLS (author)
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Yang, J (author)
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Zhang, FT (author)
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Arolt, V (author)
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Baune, BT (author)
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Berger, K (author)
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Boomsma, DI (author)
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Cichon, S (author)
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Dannlowski, U (author)
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de Geus, EJC (author)
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DePaulo, JR (author)
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Domenici, E (author)
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Domschke, K (author)
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Esko, T (author)
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Grabe, HJ (author)
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Hamilton, SP (author)
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Hayward, C (author)
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Heath, AC (author)
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Kendler, KS (author)
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Kloiber, S (author)
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Lewis, G (author)
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Li, QQS (author)
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Lucae, S (author)
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Madden, PAF (author)
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- Magnusson, PK (author)
- Karolinska Institutet
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Martin, NG (author)
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McIntosh, AM (author)
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Metspalu, A (author)
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Mors, O (author)
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Mortensen, PB (author)
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Muller-Myhsok, B (author)
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Nordentoft, M (author)
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Nothen, MM (author)
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O'Donovan, MC (author)
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Paciga, SA (author)
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- Pedersen, NL (author)
- Karolinska Institutet
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Penninx, BWJH (author)
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Perlis, RH (author)
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Porteous, DJ (author)
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Potash, JB (author)
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Preisig, M (author)
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Rietschel, M (author)
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Schaefer, C (author)
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Schulze, TG (author)
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Smoller, JW (author)
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Stefansson, K (author)
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Tiemeier, H (author)
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Uher, R (author)
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Volzke, H (author)
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Weissman, MM (author)
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Werge, T (author)
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Lewis, CM (author)
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- Levinson, DF (author)
- Karolinska Institutet
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Borglum, AD (author)
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- Sullivan, PF (author)
- Karolinska Institutet
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Meier, S (author)
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Strauss, J (author)
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Xu, W (author)
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Vincent, JB (author)
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Matthews, K (author)
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Ferreira, M (author)
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O'Dushlaine, C (author)
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Purcell, S (author)
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Raychaudhuri, S (author)
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Ruderfer, DM (author)
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Sklar, P (author)
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Scott, LJ (author)
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Flickinger, M (author)
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Burmeister, M (author)
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Li, J (author)
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Guan, WH (author)
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Absher, D (author)
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Thompson, RC (author)
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Meng, FG (author)
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Schatzberg, AF (author)
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Bunney, WE (author)
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Barchas, JD (author)
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Watson, SJ (author)
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Myers, RM (author)
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Akil, H (author)
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Boehnke, M (author)
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Chambert, K (author)
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Moran, J (author)
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Scolnick, E (author)
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Djurovic, S (author)
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Melle, I (author)
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Morken, G (author)
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- Nordin Adolfsson, Annelie (author)
- Umeå universitet,Psykiatri
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Anjorin, A (author)
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Kandaswamy, R (author)
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Lawrence, J (author)
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McLean, AW (author)
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Pickard, BS (author)
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- Bergen, SE (author)
- Karolinska Institutet
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Nimgaonkar, V (author)
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- Landen, M (author)
- Karolinska Institutet
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- Schalling, M (author)
- Karolinska Institutet
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Osby, U (author)
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- Backlund, L (author)
- Karolinska Institutet
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- Frisen, L (author)
- Karolinska Institutet
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- Langstrom, N (author)
- Karolinska Institutet
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Stahl, E (author)
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Dobbyn, A (author)
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Jamain, S (author)
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Etain, B (author)
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Bellivier, F (author)
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Leber, M (author)
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Maaser, A (author)
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Fischer, SB (author)
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Reinbold, CS (author)
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Kittel-Schneider, S (author)
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Fullerton, JM (author)
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Oruc, L (author)
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Para, JG (author)
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Mayoral, F (author)
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Rivas, F (author)
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Czerski, PM (author)
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Kammerer-Ciernioch, J (author)
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Vedder, H (author)
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Borrmann-Hassenbach, M (author)
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Pfennig, A (author)
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Brennan, P (author)
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McKay, JD (author)
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Kogevinas, M (author)
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Schwarz, M (author)
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Schofield, PR (author)
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Muhleisen, TW (author)
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Schumacher, J (author)
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Bauer, M (author)
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Wright, A (author)
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Mitchell, PB (author)
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Hautzinger, M (author)
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Kelsoe, JR (author)
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Greenwood, TA (author)
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Nievergelt, CM (author)
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Shilling, PD (author)
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Smith, EN (author)
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Bloss, CS (author)
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Edenberg, HJ (author)
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Koller, DL (author)
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Gershon, ES (author)
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Liu, CY (author)
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Badner, JA (author)
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Scheftner, WA (author)
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Lawson, WB (author)
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Nwulia, EA (author)
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Hipolito, M (author)
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Coryell, W (author)
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Rice, J (author)
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Byerley, W (author)
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McMahon, FJ (author)
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Lohoff, FW (author)
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Zandi, PP (author)
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Mahon, PB (author)
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McInnis, MG (author)
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Zollner, S (author)
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Zhang, P (author)
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Szelinger, S (author)
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St Clair, D (author)
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Caesar, S (author)
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Gordon-Smith, K (author)
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Fraser, C (author)
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Green, EK (author)
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Grozeva, D (author)
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Hamshere, ML (author)
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Kirov, G (author)
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Nikolov, I (author)
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Collier, DA (author)
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Elkin, A (author)
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Williamson, R (author)
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Young, AH (author)
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Ferrier, IN (author)
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Milanova, V (author)
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Alda, M (author)
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Cervantes, P (author)
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Cruceanu, C (author)
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Rouleau, GA (author)
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Turecki, G (author)
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Paciga, S (author)
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Winslow, AR (author)
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Grigoroiu-Serbanescu, M (author)
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Ophoff, R (author)
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Adolfsson, R (author)
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Adolfsson, AN (author)
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Del-Favero, J (author)
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Pato, C (author)
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Biernacka, JM (author)
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Frye, MA (author)
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Morris, D (author)
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Schork, NJ (author)
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Reif, A (author)
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Lissowska, J (author)
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Hauser, J (author)
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Szeszenia-Dabrowska, N (author)
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McGhee, K (author)
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Quinn, E (author)
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Moskvina, V (author)
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Holmans, PA (author)
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Farmer, A (author)
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Kennedy, JL (author)
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Andreassen, OA (author)
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Mattingsdal, M (author)
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Bass, NJ (author)
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Gurling, H (author)
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McQuillin, A (author)
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Breuer, R (author)
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Hultman, C (author)
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- Lichtenstein, P (author)
- Karolinska Institutet
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Huckins, LM (author)
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Leboyer, M (author)
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Lathrop, M (author)
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Nurnberger, J (author)
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Steffens, M (author)
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Foroud, TM (author)
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Berrettini, WH (author)
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Craig, DW (author)
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Shi, JX (author)
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(creator_code:org_t)
- 2018-10-08
- 2018
- English.
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In: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 1, s. 163-
- Related links:
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https://www.nature.c...
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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http://kipublication...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://gup.ub.gu.se...
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Abstract
Subject headings
Close
- Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
de Jong, S
-
Diniz, MJA
-
Saloma, A
-
Gadelha, A
-
Landén, Mikael, ...
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Ota, VK
-
show more...
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Noto, C
-
Curtis, C
-
Newhouse, SJ
-
Patel, H
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Hall, LS
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O'Reilly, PF
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Belangero, SI
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Adolfsson, Rolf
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Breen, G
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Wray, NR
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Ripke, S
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Mattheisen, M
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Trzaskowski, M
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Byrne, EM
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Abdellaoui, A
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Adams, MJ
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Agerbo, E
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Air, TM
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Andlauer, TFM
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Bacanu, SA
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Baekvad-Hansen, ...
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Beekman, ATF
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Bigdeli, TB
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Binder, EB
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Blackwood, DHR
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Bryois, J
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Buttenschon, HN
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Bybjerg-Grauholm ...
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Cai, N
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Castelao, E
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Christensen, JH
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Clarke, TK
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Coleman, JRI
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Colodro-Conde, L
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Couvy-Duchesne, ...
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Craddock, N
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Crawford, GE
-
Davies, G
-
Deary, IJ
-
Degenhardt, F
-
Derks, EM
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Direk, N
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Dolan, CV
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Dunn, EC
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Eley, TC
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Escott-Price, V
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Kiadeh, FFH
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Finucane, HK
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Forstner, AJ
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Frank, J
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Gaspar, HA
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Gill, M
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Goes, FS
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Gordon, SD
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Grove, J
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Hansen, CS
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Hansen, TF
-
Herms, S
-
Hickie, IB
-
Hoffmann, P
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Homuth, G
-
Horn, C
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Hottenga, JJ
-
Hougaard, DM
-
Ising, M
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Jansen, R
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Jones, I
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Jones, LA
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Jorgenson, E
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Knowles, JA
-
Kohane, IS
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Kraft, J
-
Kretzschmar, WW
-
Krogh, J
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Kutalik, Z
-
Li, YH
-
Lind, PA
-
MacIntyre, DJ
-
MacKinnon, DF
-
Maier, RM
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Maier, W
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Marchini, J
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Mbarek, H
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McGrath, P
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McGuffin, P
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Medland, SE
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Mehta, D
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Middeldorp, CM
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Mihailov, E
-
Milaneschi, Y
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Milani, L
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Mondimore, FM
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Montgomery, GW
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Mostafavi, S
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Mullins, N
-
Nauck, M
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Ng, B
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Nivard, MG
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Nyholt, DR
-
Oskarsson, H
-
Owen, MJ
-
Painter, JN
-
Pedersen, CB
-
Pedersen, MG
-
Peterson, RE
-
Pettersson, E
-
Peyrot, WJ
-
Pistis, G
-
Posthuma, D
-
Quiroz, JA
-
Qvist, P
-
Rice, JP
-
Riley, BP
-
Rivera, M
-
Mirza, SS
-
Schoevers, R
-
Schulte, EC
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Shen, L
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Shyn, SI
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Sigurdsson, E
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Sinnamon, GCB
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Smit, JH
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Smith, DJ
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Stefansson, H
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Steinberg, S
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Streit, F
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Strohmaier, J
-
Tansey, KE
-
Teismann, H
-
Teumer, A
-
Thompson, W
-
Thomson, PA
-
Thorgeirsson, TE
-
Traylor, M
-
Treutlein, J
-
Trubetskoy, V
-
Uitterlinden, AG
-
Umbricht, D
-
Van der Auwera, ...
-
van Hemert, AM
-
Viktorin, A
-
Visscher, PM
-
Wang, YP
-
Webb, BT
-
Weinsheimer, SM
-
Wellmann, J
-
Willemsen, G
-
Witt, SH
-
Wu, Y
-
Xi, HLS
-
Yang, J
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Zhang, FT
-
Arolt, V
-
Baune, BT
-
Berger, K
-
Boomsma, DI
-
Cichon, S
-
Dannlowski, U
-
de Geus, EJC
-
DePaulo, JR
-
Domenici, E
-
Domschke, K
-
Esko, T
-
Grabe, HJ
-
Hamilton, SP
-
Hayward, C
-
Heath, AC
-
Kendler, KS
-
Kloiber, S
-
Lewis, G
-
Li, QQS
-
Lucae, S
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Madden, PAF
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Magnusson, PK
-
Martin, NG
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McIntosh, AM
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Metspalu, A
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Mors, O
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Mortensen, PB
-
Muller-Myhsok, B
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Nordentoft, M
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Nothen, MM
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O'Donovan, MC
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Paciga, SA
-
Pedersen, NL
-
Penninx, BWJH
-
Perlis, RH
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Porteous, DJ
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Potash, JB
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Preisig, M
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Rietschel, M
-
Schaefer, C
-
Schulze, TG
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Smoller, JW
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Stefansson, K
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Tiemeier, H
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Uher, R
-
Volzke, H
-
Weissman, MM
-
Werge, T
-
Lewis, CM
-
Levinson, DF
-
Borglum, AD
-
Sullivan, PF
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Meier, S
-
Strauss, J
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Xu, W
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Vincent, JB
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Matthews, K
-
Ferreira, M
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O'Dushlaine, C
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Purcell, S
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Raychaudhuri, S
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Ruderfer, DM
-
Sklar, P
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Scott, LJ
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Flickinger, M
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Burmeister, M
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Li, J
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Guan, WH
-
Absher, D
-
Thompson, RC
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Meng, FG
-
Schatzberg, AF
-
Bunney, WE
-
Barchas, JD
-
Watson, SJ
-
Myers, RM
-
Akil, H
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Boehnke, M
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Chambert, K
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Moran, J
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Scolnick, E
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Djurovic, S
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Melle, I
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Morken, G
-
Nordin Adolfsson ...
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Anjorin, A
-
Kandaswamy, R
-
Lawrence, J
-
McLean, AW
-
Pickard, BS
-
Bergen, SE
-
Nimgaonkar, V
-
Landen, M
-
Schalling, M
-
Osby, U
-
Backlund, L
-
Frisen, L
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Langstrom, N
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Fullerton, JM
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Czerski, PM
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Kammerer-Ciernio ...
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Vedder, H
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Borrmann-Hassenb ...
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Pfennig, A
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Brennan, P
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Kogevinas, M
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Schofield, PR
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Muhleisen, TW
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Schumacher, J
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Williamson, R
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Andreassen, OA
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Bass, NJ
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McQuillin, A
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Breuer, R
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Hultman, C
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Lichtenstein, P
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Huckins, LM
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Leboyer, M
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Lathrop, M
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Foroud, TM
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Berrettini, WH
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Craig, DW
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Shi, JX
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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Communications b ...
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Karolinska Institutet
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Umeå University
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University of Gothenburg