Complement Activation Triggered by Biomaterial Surfaces: Mechanisms and Regulation

Complement Activation Triggered by Biomaterial Surfaces : Mechanisms and Regulation

Andersson, Jonas (author): Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi

Nilsson, Bo (thesis advisor)

Elwing, Hans, Professor (opponent): Department of Cell and Molecular Biology, Göteborg Univerity, Göteborg

(creator_code:org_t)

ISBN 9155456103
Uppsala : Acta Universitatis Upsaliensis, 2003
English 45 s.
Series: Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 0282-7476 ; 1253

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Abstract Subject headings

Today there are a vast number of medical devices in temporary or permanent contact with human tissues. Blood-biomaterial contact is known to trigger the complement system and results in generation of fluid phase anaphylatoxins C3a and C5a, and surface-bound C3b and iC3b. All these products together are able to attract and activate leukocytes and trigger release of inflammatory mediators leading to a systemic inflammation indirectly causing hemostatic problems and even organ failure. The aim of this study was to identify how complement is triggered on a biomaterial surface and to find ways to regulate this activation.The finding that complement activation on biomaterials can be divided into initiation and amplification will facilitate regulation of complement activation biomaterial surfaces. This concept is also compatible with the two techniques to regulate complement activation on a surface.

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Immunology in th ...

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