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FältnamnIndikatorerMetadata
00006175naa a2200877 4500
001oai:DiVA.org:oru-33885
003SwePub
008140221s2013 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-187166
009oai:DiVA.org:liu-89740
024a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-338852 URI
024a https://doi.org/10.1097/MPG.0b013e318272cbf42 DOI
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1871662 URI
024a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-897402 URI
040 a (SwePub)orud (SwePub)uud (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Stenberg, Reidun,d 1954-u Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,Dept of Paediatrics, Centre for Rehabilitation Research, Örebro University Hospital,,Örebro University Hospital, Sweden4 aut0 (Swepub:oru)rsg
2451 0a Increased prevalence of antibodies against dietary proteins in children and young adults with cerebral palsy
264 1b Lippincott, Williams and Wilkins,c 2013
338 a print2 rdacarrier
500 a Funding agencies are:Research Committee of Orebro County Council  Folke Bernadotte Foundation, Stockholm, Sweden 
500 a Funding Agencies|Research Committee of Orebro County Council||Folke Bernadotte Foundation, Stockholm, Sweden||
520 a OBJECTIVES: Undernourishment is common in children with cerebral palsy (CP), but the reasons are unknown. We previously reported elevated levels of immunoglobulin (Ig) A and IgG antibodies against gliadin (AGA) and tissue transglutaminase (tTG) in 99 children and young adults with CP without characteristic findings of gluten enteropathy in small bowel biopsies. Our aim was to perform a case-control study of IgG antibodies against other dietary antigens, AGA, anti-tTG, and IgE antibodies against wheat and gluten.METHODS: Sera from 99 cases with CP and 99 healthy, age- and sex-matched controls were analysed with fluorescence enzyme-linked immunosorbent assay for detection of IgG antibodies against β-lactoglobulin, casein, egg white, IgG- and IgA-AGA, IgA-anti-tTG, and IgE antibodies against gluten and wheat.RESULTS: Compared with controls, the odds ratio in cases with CP for having elevated levels of IgG antibodies against β-lactoglobulin was 17.0 (95% confidence interval [CI] 2.3-128), against casein 11.0 (95% CI 2.6-46.8), and against egg white 7.0 (95% CI 1.6-30.8). The IgE responses for wheat/gluten were generally low. The tetraplegic and dyskinetic CP subtypes had significantly higher frequencies of elevated levels for all of the tested antibodies except IgG against egg white, and IgA-anti-tTG. A significantly lower weight was seen in cases with CP with positive versus negative serology.CONCLUSIONS: Elevated levels of IgG against dietary antigens were more frequent in the CP group compared with controls, and particularly in the tetraplegic and dyskinetic CP subtypes with the most severe neurologic handicap and undernourishment. Hypothetically, malnourishment may cause increased intestinal permeability and thus immunization against dietary antigens.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
653 a Adolescent
653 a Adult
653 a Antibodies
653 a Autoantibodies
653 a Body Weight
653 a Case-Control Studies
653 a Caseins
653 a Celiac Disease
653 a Cerebral Palsy
653 a Child
653 a Child
653 a Preschool
653 a Dietary Proteins
653 a Egg White
653 a Female
653 a Glutens
653 a Humans
653 a Immunoglobulin A
653 a Immunoglobulin E
653 a Immunoglobulin G
653 a Infant
653 a Lactoglobulins
653 a Male
653 a Malnutrition
653 a Transglutaminases
653 a Triticum
653 a Young Adult
653 a Invärtesmedicin
653 a Internal Medicine
653 a Pediatrik
653 a Pediatrics
653 a Nutrition
653 a Näringslära
653 a MEDICINE
700a Dahle, Charlotteu Östergötlands Läns Landsting,Linköpings universitet,Klinisk immunologi,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin4 aut0 (Swepub:liu)chada46
700a Magnuson, Andersu Clinical Epidemiology and Biostatistic Unit, Örebro University Hospital, Örebro, Sweden4 aut
700a Hellberg, Dan,d 1953-u Uppsala universitet,Centrum för klinisk forskning Dalarna,Obstetrik & gynekologi,Reproduktiv hälsa/Sundström Poromaa,Clin Research Centre, Sweden4 aut0 (Swepub:uu)dahel227
700a Tysk, Curtu Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Medicine, Örebro University Hospital, Region Örebro County, Örebro, Sweden,Department of Medicine, Division of Gastroenterology, Örebro University Hospital4 aut0 (Swepub:oru)ctk
710a Örebro universitetb Institutionen för hälsovetenskap och medicin4 org
773t Journal of Pediatric Gastroenterology and Nutrition - JPGNd : Lippincott, Williams and Wilkinsg 56:2, s. 233-8q 56:2<233-8x 0277-2116x 1536-4801
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-33885
8564 8u https://doi.org/10.1097/MPG.0b013e318272cbf4
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-187166
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-89740

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