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Insulin-like Growth...
Insulin-like Growth Factor-I Concentration and Risk of Prostate Cancer : Results from the European Prospective Investigation into Cancer and Nutrition
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Price, Alison J. (author)
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Allen, Naomi E. (author)
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Appleby, Paul N. (author)
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Crowe, Francesca L. (author)
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Travis, Ruth C. (author)
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Tipper, Sarah J. (author)
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Overvad, Kim (author)
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Gronbaek, Henning (author)
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Tjonneland, Anne (author)
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Johnsen, Nina Fons (author)
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Rinaldi, Sabina (author)
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Kaaks, Rudolf (author)
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Lukanova, Annie (author)
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Boeing, Heiner (author)
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Aleksandrova, Krasimira (author)
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Trichopoulou, Antonia (author)
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Trichopoulos, Dimitrios (author)
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Andarakis, George (author)
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Palli, Domenico (author)
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Krogh, Vittorio (author)
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Tumino, Rosario (author)
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Sacerdote, Carlotta (author)
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Bueno-de-Mesquita, H. Bas (author)
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Argueelles, Marcial V. (author)
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Sanchez, Maria-Jose (author)
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Chirlaque, Maria-Dolores (author)
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Barricarte, Aurelio (author)
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Larranaga, Nerea (author)
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Gonzalez, Carlos A. (author)
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- Stattin, Pär (author)
- Umeå universitet,Urologi och andrologi,Department of Surgery, Urology Service, Memorial Sloan-Kettering Cancer Center, New York
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- Johansson, Mattias (author)
- Umeå universitet,Näringsforskning
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Khaw, Kay-Tee (author)
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Wareham, Nick (author)
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Gunter, Marc (author)
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Riboli, Elio (author)
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Key, Timothy (author)
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(creator_code:org_t)
- 2012
- 2012
- English.
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In: Cancer Epidemiology, Biomarkers and Prevention. - 1055-9965 .- 1538-7755. ; 21:9, s. 1531-1541
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: High circulating insulin-like growth factor-I (IGF-I) concentrations have been associated with increased risk for prostate cancer in several prospective epidemiological studies. In this study, we investigate the association between circulating IGF-I concentration and risk of prostate cancer over the long term in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Methods: In a nested case-control design, 1,542 incident prostate cancer cases from eight European countries were individually matched to 1,542 controls by study center, age at recruitment, duration of follow-up, time of day, and duration of fasting at blood collection. Conditional logistic regression models were used to calculate risk for prostate cancer associated with IGF-I concentration, overall and by various subgroups. Results: Circulating IGF-I concentration was associated with a significant increased risk for prostate cancer [OR for highest vs. lowest quartile, 1.69; 95% confidence interval (CI), 1.35-2.13; P-trend = 0.0002]. This positive association did not differ according to duration of follow-up [ORs for highest vs. lowest quartile were 2.01 (1.35-2.99), 1.37 (0.94-2.00), and 1.80 (1.17-2.77) for cancers diagnosed <4, 4-7, and >7 years after blood collection, respectively (P-heterogeneity = 0.77)] or by stage, grade, and age at diagnosis or age at blood collection (all subgroups P-heterogeneity >0.05). Conclusion: In this European population, high circulating IGF-I concentration is positively associated with risk for prostate cancer over the short and long term. Impact: As IGF-I is the only potentially modifiable risk factor so far identified, research into the effects of reducing circulating IGF-I levels on subsequent prostate cancer risk is warranted.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
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- By the author/editor
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Price, Alison J.
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Allen, Naomi E.
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Appleby, Paul N.
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Crowe, Francesca ...
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Travis, Ruth C.
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Tipper, Sarah J.
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show more...
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Overvad, Kim
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Gronbaek, Hennin ...
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Tjonneland, Anne
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Johnsen, Nina Fo ...
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Rinaldi, Sabina
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Kaaks, Rudolf
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Lukanova, Annie
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Boeing, Heiner
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Aleksandrova, Kr ...
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Trichopoulou, An ...
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Trichopoulos, Di ...
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Andarakis, Georg ...
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Palli, Domenico
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Krogh, Vittorio
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Tumino, Rosario
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Sacerdote, Carlo ...
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Bueno-de-Mesquit ...
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Argueelles, Marc ...
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Sanchez, Maria-J ...
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Chirlaque, Maria ...
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Barricarte, Aure ...
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Larranaga, Nerea
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Gonzalez, Carlos ...
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Stattin, Pär
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Johansson, Matti ...
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Khaw, Kay-Tee
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Wareham, Nick
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Gunter, Marc
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Riboli, Elio
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Key, Timothy
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
- Articles in the publication
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Cancer Epidemiol ...
- By the university
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Umeå University