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Sökning: AMNE:(MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes) > The Combination of ...

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FältnamnIndikatorerMetadata
00008528naa a2201057 4500
001oai:DiVA.org:his-23666
003SwePub
008240321s2024 | |||||||||||000 ||eng|
009oai:gup.ub.gu.se/336181
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-236662 URI
0247 a https://doi.org/10.3390/cells130504142 DOI
0247 a https://gup.ub.gu.se/publication/3361812 URI
040 a (SwePub)hisd (SwePub)gu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Tejedor, Sandrau Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden,Translationell bioinformatik, Translational Bioinformatics4 aut0 (Swepub:his)tejs
2451 0a The Combination of Vascular Endothelial Growth Factor A (VEGF-A) and Fibroblast Growth Factor 1 (FGF1) Modified mRNA Improves Wound Healing in Diabetic Mice :b An Ex Vivo and In Vivo Investigation
264 1b MDPI,c 2024
338 a electronic2 rdacarrier
500 a CC BY 4.0 DEED© 2024 by the authors.Correspondence Address: S. Tejedor; Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, 431 50, Sweden; email: sandra.tejedorgascon1@astrazeneca.com; K. Hansson; Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, 431 50, Sweden; email: kenny.m.hansson@astrazeneca.comThis research was partially funded by grants from the Swedish Knowledge Foundation, grant number 20200014.
520 a Background: Diabetic foot ulcers (DFU) pose a significant health risk in diabetic patients, with insufficient revascularization during wound healing being the primary cause. This study aimed to assess microvessel sprouting and wound healing capabilities using vascular endothelial growth factor (VEGF-A) and a modified fibroblast growth factor (FGF1). Methods: An ex vivo aortic ring rodent model and an in vivo wound healing model in diabetic mice were employed to evaluate the microvessel sprouting and wound healing capabilities of VEGF-A and a modified FGF1 both as monotherapies and in combination. Results: The combination of VEGF-A and FGF1 demonstrated increased vascular sprouting in the ex vivo mouse aortic ring model, and topical administration of a combination of VEGF-A and FGF1 mRNAs formulated in lipid nanoparticles (LNPs) in mouse skin wounds promoted faster wound closure and increased neovascularization seven days post-surgical wound creation. RNA-sequencing analysis of skin samples at day three post-wound creation revealed a strong transcriptional response of the wound healing process, with the combined treatment showing significant enrichment of genes linked to skin growth. Conclusion: f-LNPs encapsulating VEGF-A and FGF1 mRNAs present a promising approach to improving the scarring process in DFU.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
650 7a LANTBRUKSVETENSKAPERx Veterinärmedicinx Klinisk vetenskap0 (SwePub)403032 hsv//swe
650 7a AGRICULTURAL SCIENCESx Veterinary Sciencex Clinical Science0 (SwePub)403032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
653 a angiogenesis
653 a diabetes
653 a diabetic foot ulcer
653 a FGF1
653 a revascularization
653 a VEGF-A
653 a wound healing
653 a Animals
653 a Diabetes Mellitus
653 a Experimental
653 a Diabetic Foot
653 a Disease Models
653 a Animal
653 a Fibroblast Growth Factor 1
653 a Humans
653 a Mice
653 a Neovascularization
653 a Physiologic
653 a Vascular Endothelial Growth Factor A
653 a vasculotropin A
653 a animal
653 a disease model
653 a experimental diabetes mellitus
653 a human
653 a metabolism
653 a mouse
653 a physiology
653 a Bioinformatik
653 a Bioinformatics
653 a diabetes
653 a diabetic foot ulcer
653 a angiogenesis
653 a revascularization
653 a VEGF-A
653 a FGF1
653 a wound healing
7001 a Wågberg, Mariau Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden4 aut
7001 a Correia, Cláudiau Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden4 aut
7001 a Åvall, Karinu Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden4 aut
7001 a Hölttä, Mikkou Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden4 aut
7001 a Hultin, Leifu Imaging and Data Analytics, Clinical and Pharmacological Safety Science, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden4 aut
7001 a Lerche, Michaelu Advanced Drug Delivery, Pharmaceutical Science, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden4 aut
7001 a Davies, Nigelu Advanced Drug Delivery, Pharmaceutical Science, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden4 aut
7001 a Bergenhem, Nilsu Alliance Management, Business Development and Licensing, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, United States4 aut
7001 a Snijder, Arjanu Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden4 aut
7001 a Marlow, Tomu Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden4 aut
7001 a Dönnes, Pierreu Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,SciCross AB, Skövde, Sweden,Translationell bioinformatik, Translational Bioinformatics4 aut0 (Swepub:his)donp
7001 a Fritsche-Danielson, Reginau Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden4 aut
7001 a Synnergren, Janeu Gothenburg University,Göteborgs universitet,Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Department of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Translationell bioinformatik ,Translational Bioinformatics,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xsynja
7001 a Jennbacken, Karinu Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden4 aut
7001 a Hansson, Kennyu Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden4 aut
7102 a Högskolan i Skövdeb Institutionen för biovetenskap4 org
7730 t Cellsd : MDPIg 13:5q 13:5x 2073-4409
8564 u https://doi.org/10.3390/cells13050414y Fulltext
8564 u https://his.diva-portal.org/smash/get/diva2:1846121/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-23666
8564 8u https://doi.org/10.3390/cells13050414
8564 8u https://gup.ub.gu.se/publication/336181

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