L773:0094 2405 OR L773:2473 4209
Sökning: L773:0094 2405 OR L773:2473 4209 > Intracranial haemor...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05121naa a2200469 4500 | |
| 001 | oai:DiVA.org:kth-176635 | |
| 003 | SwePub | |
| 008 | 151109s2016 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:hb-8614 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-1766352 URI |
| 024 | 7 | a https://doi.org/10.1118/1.49392562 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-86142 URI |
| 040 | a (SwePub)kthd (SwePub)hb | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Atefi, Seyed Rezau KTH,Medicinska sensorer, signaler och system,Harvard Univsersity4 aut0 (Swepub:kth)u1j860kl |
| 245 | 1 0 | a Intracranial haemorrhage alters scalp potential distributions in bioimpedance cerebral monitoring applications :b preliminary results from FEM simulation on a realistic head model and human subjects |
| 264 | c 2016-01-13 | |
| 264 | 1 | b American Association of Physicists in Medicine,c 2016 |
| 338 | a print2 rdacarrier | |
| 500 | a QC 20170111 | |
| 500 | a QS 2015 | |
| 520 | a Purpose: Current diagnostic neuroimaging for detection of intracranial hemorrhage (ICH) is limited to fixed scanners requiring patient transport and extensive infrastructure support. ICH diagnosis would therefore benefit from a portable diagnostic technology, such as electrical bioimpedance (EBI). Through simulations and patient observation, the authors assessed the influence of unilateral ICH hematomas on quasisymmetric scalp potential distributions in order to establish the feasibility of EBI technology as a potential tool for early diagnosis. Methods: Finite element method (FEM) simulations and experimental leftright hemispheric scalp potential differences of healthy and damaged brains were compared with respect to the asymmetry caused by ICH lesions on quasisymmetric scalp potential distributions. In numerical simulations, this asymmetry was measured at 25 kHz and visualized on the scalp as the normalized potential difference between the healthy and ICH damaged models. Proof-of-concept simulations were extended in a pilot study of experimental scalp potential measurements recorded between 0 and 50 kHz with the authors custom-made bioimpedance spectrometer. Mean leftright scalp potential differences recorded from the frontal, central, and parietal brain regions of ten healthy control and six patients suffering from acute/subacute ICH were compared. The observed differences were measured at the 5% level of significance using the two-sample Welch ttest. Results: The 3D-anatomically accurate FEM simulations showed that the normalized scalp potential difference between the damaged and healthy brain models is zero everywhere on the head surface, except in the vicinity of the lesion, where it can vary up to 5%. The authors preliminary experimental results also confirmed that the leftright scalp potential difference in patients with ICH (e.g., 64 mV) is significantly larger than in healthy subjects (e.g., 20.8 mV; P < 0.05). Conclusions: Realistic, proof-of-concept simulations confirmed that ICH affects quasisymmetric scalp potential distributions. Pilot clinical observations with the authors custom-made bioimpedance spectrometer also showed higher leftright potential differences in the presence of ICH, similar to those of their simulations, that may help to distinguish healthy subjects from ICH patients. Although these pilot clinical observations are in agreement with the computer simulations, the small sample size of this study lacks statistical power to exclude the influence of other possible confounders such as age, ex, and electrode positioning. The agreement with previously published simulation-based and clinical results, however, suggests that EBI technology may be potentially useful for ICH detection. | |
| 650 | 7 | a TEKNIK OCH TEKNOLOGIERx Medicinteknik0 (SwePub)2062 hsv//swe |
| 650 | 7 | a ENGINEERING AND TECHNOLOGYx Medical Engineering0 (SwePub)2062 hsv//eng |
| 653 | a bioimpedance; FEM simulations; intracranial hemorrhage; prehospital triage; scalp equipotential lines | |
| 653 | a Applied Medical Technology | |
| 653 | a Tillämpad medicinsk teknik | |
| 653 | a Människan i vården | |
| 700 | 1 | a Seoane, Fernandou Högskolan i Borås,KTH,Medicinska sensorer, signaler och system,Akademin för vård, arbetsliv och välfärd,KTH-School of Technology and Health4 aut0 (Swepub:hb)fsm |
| 700 | 1 | a Kamalian, Shervin4 aut |
| 700 | 1 | a Rosenthal, Eric4 aut |
| 700 | 1 | a Lev, Michaelu Massachussets University Hospital4 aut |
| 700 | 1 | a Bonmassar, Giorgiou Harvard University4 aut |
| 710 | 2 | a KTHb Medicinska sensorer, signaler och system4 org |
| 773 | 0 | t Medical Physicsd : American Association of Physicists in Medicineg 43:2, s. 675-686q 43:2<675-686x 2473-4209x 0094-2405 |
| 856 | 4 | u https://europepmc.org/articles/pmc4715008?pdf=render |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-176635 |
| 856 | 4 8 | u https://doi.org/10.1118/1.4939256 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-8614 |
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