Activated T cells in the nasal mucosa of patients with grass-pollen allergy. A pilot study

Six patients with grass-pollen allergy were provoked with water-soluble grass pollen until a pronounced allergic reaction occurred. This was performed outside the grass-pollen season, and the allergen was administered on the edge of the inferior turbinate. Biopsies were taken both before provocation and during the reaction, 15-30 minutes after provocation. The nasal population of immunohistochemically positive cells for HLA-DR, CD1, interleukin-2-receptor, IgE, CD4 and CD8 were studied. There was a marked increase of IL2-R-positive cells (activated T lymphocytes) in the nasal mucosa after provocation, whilst the other cell populations approximately remained unchanged (apart from a certain increase of IgE). The increase of activated T lymphocytes may imply that certain subsets of T cells play a role in the allergic response, and that the role of helper T cells very likely is much more complex than the regulation of mast cells and eosinophils. The concomitant presence of Langerhans' cells (CD1-positive) and activated T lymphocytes may indicate a possible association on site between an antigen-presenting cell and both effector as well as memory cells in allergic reactions.

Karlsson, Mats G.,1960-Örebro Medical Center, Örebro, Sweden(Swepub:oru)mskn (författare)
Rudblad, S. (författare)
Ekedahl, C. (författare)
Davidsson, Åke,1956-Örebro Medical Center, Örebro, Sweden(Swepub:oru)adn (författare)
Örebro Medical Center, Örebro, Sweden (creator_code:org_t)

Ingår i:RhinologyAmsterdam, Netherlands : International Rhinologic Society30:1, s. 57-630300-07291996-8604

Av författaren/redakt...: Hellquist, H. B.; Karlsson, Mats G ...; Rudblad, S.; Ekedahl, C.; Davidsson, Åke, ...

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